Difference between revisions of "Bioblast alert 2015"
From Bioblast
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Contributions are welcome. | Contributions are welcome. | ||
=== Bioblast alert 2012(07): 2012-10-24 === | |||
* '''MitoPedia topic''': Publications of historical interest are valued as milestones in science, as sources of understanding currently discussed concepts, and as a reminder that 'nothing' is new (something new is 'nothing'?) >> '''[[Mitochondria and bioblasts: Made history]]''' | |||
* '''MitoPedia terminology''': [[LEAK]] ''vs.'' [[State 2]]: The resting state of substrate supported respiration without ADP (LEAK state) in contrast to the substrate limited State 2 of [[residual oxygen consumption]] at high ADP concentration: >> [[Chance 1955 J Biol Chem-III|Chance and Williams 1955]]. | |||
: '''MitoPedia Glossary:''' [[Glossary: Respiratory states|'''Respiratory states''']] | |||
* [[Bioblast 2012|'''Bioblast 2012''': Conference on Mitochondrial Competence]] in the spirit of [[Gentle Science]]. | |||
=== [[Bioblast alert|Bioblast alert]] 2012(06): 2012-07-20 === | === [[Bioblast alert|Bioblast alert]] 2012(06): 2012-07-20 === | ||
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* '''Comparison of common bioenergetic analysis methods''': [[Zhang_2012_Nat Protoc|Zhang J, Nuebel E, Wisidagama DR, Setoguchi K, Hong JS, Van Horn CM, Imam SS, Vergnes L, Malone CS, Koehler CM, Teitell MA (2012) Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells Nat Protoc 7: 1068-1085.]] >> ''Continue the [[O2k_versus_multiwell_respirometer|discussion]]'' | * '''Comparison of common bioenergetic analysis methods''': [[Zhang_2012_Nat Protoc|Zhang J, Nuebel E, Wisidagama DR, Setoguchi K, Hong JS, Van Horn CM, Imam SS, Vergnes L, Malone CS, Koehler CM, Teitell MA (2012) Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells Nat Protoc 7: 1068-1085.]] >> ''Continue the [[O2k_versus_multiwell_respirometer|discussion]]'' | ||
== Bioblast alert 2012(04): 2012-04-29 == | === Bioblast alert 2012(04): 2012-04-29 === | ||
* '''MitoPedia topic''': '''''Mitochondria''''' - can we decide on a common abbreviation? - or simply call them '''''[[Bioblasts]]'''''. --> '''[[Mitochondria]]''' and [[Talk:Mitochondria]] | * '''MitoPedia topic''': '''''Mitochondria''''' - can we decide on a common abbreviation? - or simply call them '''''[[Bioblasts]]'''''. --> '''[[Mitochondria]]''' and [[Talk:Mitochondria]] | ||
* '''Bioblast news''': '''Light in the powerhouse of the cells''' - [http://www.oroboros.at/?Houska-Award_2011 a mt-project is the winner of the Houska Award 2011]. | * '''Bioblast news''': '''Light in the powerhouse of the cells''' - [http://www.oroboros.at/?Houska-Award_2011 a mt-project is the winner of the Houska Award 2011]. | ||
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::[[Votion 2012 PLoS One|Votion DM, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D (2012) Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle. PLoS One 7(4): e34890.]] | ::[[Votion 2012 PLoS One|Votion DM, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D (2012) Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle. PLoS One 7(4): e34890.]] | ||
== Bioblast alert 2012(03): 2012-03-23 / 2012-04-03 == | === Bioblast alert 2012(03): 2012-03-23 / 2012-04-03 === | ||
'''MitoPedia topic''': '''[[Permeabilized_muscle_fibres#Oxygen_dependence_of_ROS_production_-_are_permeabilized_fibres_a_valid_model.3F|Oxygen dependence of ROS production - are permeabilized fibres a valid model?]]''' | '''MitoPedia topic''': '''[[Permeabilized_muscle_fibres#Oxygen_dependence_of_ROS_production_-_are_permeabilized_fibres_a_valid_model.3F|Oxygen dependence of ROS production - are permeabilized fibres a valid model?]]''' | ||
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== Bioblast alert 2012(02): 2012-03-06 == | === Bioblast alert 2012(02): 2012-03-06 === | ||
* '''50 Years ago''': '''Nick Holonyak''', considered as the "father of the light-emitting diode", developed the first practical '''visible-spectrum LED in 1962'''. ''Which colour? What is a'' '''LED'''''?'' >>> see '''[[Light emitting diode|Glossary: Fluorescence]]''' | * '''50 Years ago''': '''Nick Holonyak''', considered as the "father of the light-emitting diode", developed the first practical '''visible-spectrum LED in 1962'''. ''Which colour? What is a'' '''LED'''''?'' >>> see '''[[Light emitting diode|Glossary: Fluorescence]]''' | ||
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# [[Holmstroem 2012 Am J Physiol Endocrinol Metab|Holmstroem MH, Iglesias-Gutierrez E, Zierath JR, Garcia-Roves PM (2012) Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes. Am J Physiol Endocrinol Metab 302: E731-E739.]] | # [[Holmstroem 2012 Am J Physiol Endocrinol Metab|Holmstroem MH, Iglesias-Gutierrez E, Zierath JR, Garcia-Roves PM (2012) Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes. Am J Physiol Endocrinol Metab 302: E731-E739.]] | ||
== Bioblast alert 2012(01): 2012-02-27 == | === Bioblast alert 2012(01): 2012-02-27 === | ||
Two exciting publications on '''mitochondrial [[p50|''p''<sub>50</sub>]]''', apparent [[excess capacity]] of cytochrome c oxidase, '''[[basal metabolic rate]]''', [[P/O ratio]]s and ergometric [[efficiency]]: | Two exciting publications on '''mitochondrial [[p50|''p''<sub>50</sub>]]''', apparent [[excess capacity]] of cytochrome c oxidase, '''[[basal metabolic rate]]''', [[P/O ratio]]s and ergometric [[efficiency]]: | ||
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== Bioblast alert 2011(04): 2011-12-24 == | === Bioblast alert 2011(04): 2011-12-24 === | ||
* '''Congratulations''' to [[Pesta D|Dr. Dominik Pesta]], for receiving his degree of a PhD at the Medical University of Innsbruck! (Jan 2012) | * '''Congratulations''' to [[Pesta D|Dr. Dominik Pesta]], for receiving his degree of a PhD at the Medical University of Innsbruck! (Jan 2012) | ||
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== Bioblast alert 2011(03): 2011-11-24 == | === Bioblast alert 2011(03): 2011-11-24 === | ||
* '''Fluorometry combined with high-resolution respirometry''': Light guide inserted into the chamber through a black PEEK stopper<ref>[[Anderson 2011 Am J Physiol Heart Circ Physiol|Anderson EJ, Rodriguez E, Anderson CA, Thayne K, Chitwood WR, Kypson AP (2011) Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways. Am J Physiol Heart Circ Physiol 300: H118-124.]]</ref>, or optical probe operated through the O2k-glass window<ref>[[Hickey 2012 J Comp Physiol B|Hickey AJ, Renshaw GM, Speers-Roesch B, Richards JG, Wang Y, Farrell AP, Brauner CJ (2012) A radical approach to beating hypoxia: depressed free radical release from heart fibres of the hypoxia-tolerant epaulette shark (''Hemiscyllum ocellatum''). J Comp Physiol B [Epub ahead of print] ]]</ref>. | * '''Fluorometry combined with high-resolution respirometry''': Light guide inserted into the chamber through a black PEEK stopper<ref>[[Anderson 2011 Am J Physiol Heart Circ Physiol|Anderson EJ, Rodriguez E, Anderson CA, Thayne K, Chitwood WR, Kypson AP (2011) Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways. Am J Physiol Heart Circ Physiol 300: H118-124.]]</ref>, or optical probe operated through the O2k-glass window<ref>[[Hickey 2012 J Comp Physiol B|Hickey AJ, Renshaw GM, Speers-Roesch B, Richards JG, Wang Y, Farrell AP, Brauner CJ (2012) A radical approach to beating hypoxia: depressed free radical release from heart fibres of the hypoxia-tolerant epaulette shark (''Hemiscyllum ocellatum''). J Comp Physiol B [Epub ahead of print] ]]</ref>. | ||
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== Bioblast alert 2011(02): 2011-11-17 == | === Bioblast alert 2011(02): 2011-11-17 === | ||
* '''[http://www.oroboros.at/index.php?ioc64 O2k-Workshop IOC64 - Centre for Cellular and Molecular Biology, Hyderabad, India]: 2011-12-08'''. | * '''[http://www.oroboros.at/index.php?ioc64 O2k-Workshop IOC64 - Centre for Cellular and Molecular Biology, Hyderabad, India]: 2011-12-08'''. | ||
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== Bioblast alert 2011(01): 2011-11-11 == | === Bioblast alert 2011(01): 2011-11-11 === | ||
* A key question on the separation of '''qualitative versus quantitative change of mitochondrial function''' is addressed in a new O2k-Publication. Does training induce mild uncoupling? Are sedentary humans healthy controls? | * A key question on the separation of '''qualitative versus quantitative change of mitochondrial function''' is addressed in a new O2k-Publication. Does training induce mild uncoupling? Are sedentary humans healthy controls? | ||
Revision as of 21:07, 24 October 2012
Bioblast alert is prepared by the Bioblast editorial board to draw attention to specific topics on the Bioblast wiki.
Bioblast alert: for information purposes, not intended to be an advertisement. Contributions are welcome.
Bioblast alert 2012(07): 2012-10-24
- MitoPedia topic: Publications of historical interest are valued as milestones in science, as sources of understanding currently discussed concepts, and as a reminder that 'nothing' is new (something new is 'nothing'?) >> Mitochondria and bioblasts: Made history
- MitoPedia terminology: LEAK vs. State 2: The resting state of substrate supported respiration without ADP (LEAK state) in contrast to the substrate limited State 2 of residual oxygen consumption at high ADP concentration: >> Chance and Williams 1955.
- MitoPedia Glossary: Respiratory states
- Bioblast 2012: Conference on Mitochondrial Competence in the spirit of Gentle Science.
Bioblast alert 2012(06): 2012-07-20
- MitoPedia news: Myxothiazol is available again, but what about α-glycerophosphate ?
- >> More information on the MitoPedia list Substrates and metabolites
- MitoPedia terminology: State 3 - is [ADP] saturating? Not generally in State 3, but certainly in the OXPHOS state (P).
- >> Update on the MitoPedia glossary: Respiratory states
- Hypoxia and high altitude: CH Zurich Lundby C, DK Copenhagen Boushel RC, AT Innsbruck Gnaiger E
- Jacobs RA, Boushel RC, Wright-Paradis C, Calbet JA, Robach P, Gnaiger E, Lundby C (2012) Mitochondrial function in human skeletal muscle following high altitude exposure. Exp Physiol [Epub ahead of print].
- Robach P, Siebenmann C, Jacobs RA, Rasmussen P, Nordsborg N, Pesta D, Gnaiger E, Díaz V, Christ A, Fiedler J, Crivelli N, Secher NH, Pichon A, Maggiorini M, Lundby C (2012) The role of haemoglobin mass on VO2max following normobaric 'live high-train low' in endurance-trained athletes. Br J Sports Med Jul 12. [Epub ahead of print].
- Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans. Am J Physiol Regul Integr Comp Physiol 301: R1078–R1087.
- Scandurra FM, Gnaiger E (2010) Cell respiration under hypoxia: Facts and artefacts in mitochondrial oxygen kinetics. Adv Exp Med Biol 662: 7-25.
Bioblast alert 2012(05): 2012-06-05
- MitoPedia topic: Mitochondria and Genetics - the Coactivator PGC-1α
- Bioblast announcement: UMDF: Mitochondrial Medicine 2012 - 2012-June-13 to 16 - Capitol Hill, Bethesda, Washington DC, USA
- Comparison of common bioenergetic analysis methods: Zhang J, Nuebel E, Wisidagama DR, Setoguchi K, Hong JS, Van Horn CM, Imam SS, Vergnes L, Malone CS, Koehler CM, Teitell MA (2012) Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells Nat Protoc 7: 1068-1085. >> Continue the discussion
Bioblast alert 2012(04): 2012-04-29
- MitoPedia topic: Mitochondria - can we decide on a common abbreviation? - or simply call them Bioblasts. --> Mitochondria and Talk:Mitochondria
- Bioblast news: Light in the powerhouse of the cells - a mt-project is the winner of the Houska Award 2011.
- Comparative mt-physiology - life style and training:
Bioblast alert 2012(03): 2012-03-23 / 2012-04-03
MitoPedia topic: Oxygen dependence of ROS production - are permeabilized fibres a valid model?
--> Discussion
Drosophila vs. sandworm: High-resolution respirometry in permeabilized muscle fibres
- Pichaud N, Rioux P, Blier PU (2012) In situ quantification of mitochondrial respiration in permeabilized fibers of a marine invertebrate with low aerobic capacity. Comp Biochem Physiol A Mol Integr Physiol 161: 429-435.
- Pichaud N, Ballard JWO, Tanguay RM, Blier PU (2011) Thermal sensitivity of mitochondrial functions in permeabilized muscle fibers from two populations of Drosophila simulans with divergent mitotypes. Am J Physiol Regul Integr Comp Physiol 301: R48-R49.
New from the Ballard lab:
Bioblast alert 2012(02): 2012-03-06
- 50 Years ago: Nick Holonyak, considered as the "father of the light-emitting diode", developed the first practical visible-spectrum LED in 1962. Which colour? What is a LED? >>> see Glossary: Fluorescence
Mitochondrial dys/function in obesity vs. anorexia:
- Lindfors C, Nilsson IA, Garcia-Roves PM, Zuberi AR, Karimi M, Donahue LR, Roopenian DC, Mulder J, Uhlén M, Ekström TJ, Davisson MT, Hökfelt TG, Schalling M, Johansen JE (2011) Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse. Proc Natl Acad Sci U S A 108: 18108-18113.
- Holmstroem MH, Iglesias-Gutierrez E, Zierath JR, Garcia-Roves PM (2012) Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes. Am J Physiol Endocrinol Metab 302: E731-E739.
Bioblast alert 2012(01): 2012-02-27
Two exciting publications on mitochondrial p50, apparent excess capacity of cytochrome c oxidase, basal metabolic rate, P/O ratios and ergometric efficiency:
- Larsen FJ, Schiffer TA, Sahlin K, Ekblom B, Weitzberg E, Lundberg JO (2011) Mitochondrial oxygen affinity predicts basal metabolic rate in humans. FASEB J 25: 2843-2852.
- Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, Weitzberg E (2011) Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab 13: 149-159.
Bioblast alert 2011(04): 2011-12-24
- Congratulations to Dr. Dominik Pesta, for receiving his degree of a PhD at the Medical University of Innsbruck! (Jan 2012)
- Bioblast editorial board - Why a wiki editorial board?
- SUIT protocols for HRR: from intact cells to permeabilized muscle fibres:
Bioblast alert 2011(03): 2011-11-24
- Fluorometry combined with high-resolution respirometry: Light guide inserted into the chamber through a black PEEK stopper[1], or optical probe operated through the O2k-glass window[2].
- ↑ Anderson EJ, Rodriguez E, Anderson CA, Thayne K, Chitwood WR, Kypson AP (2011) Increased propensity for cell death in diabetic human heart is mediated by mitochondrial-dependent pathways. Am J Physiol Heart Circ Physiol 300: H118-124.
- ↑ Hickey AJ, Renshaw GM, Speers-Roesch B, Richards JG, Wang Y, Farrell AP, Brauner CJ (2012) A radical approach to beating hypoxia: depressed free radical release from heart fibres of the hypoxia-tolerant epaulette shark (Hemiscyllum ocellatum). J Comp Physiol B [Epub ahead of print]
- Fluorometry versus fluorimetry - term of the week. >>>New Glossary: Fluorometry - high-resolution terminology.
Bioblast alert 2011(02): 2011-11-17
- Heart failure and mitochondrial dysfunction. Increased OXPHOS capacity after cold preservation of the human heart – a paradox resolved by a dyscoupling mechanism.
- Tissue storage on ice is possible for limited periods of time (several hours) with preservation of mitochondrial respiratory function, as evaluated with SUIT protocols. (Scientific service)
- Uncoupled, non-coupled, dyscoupled - term of the week: a hallmark of high-resolution respirometry is a matching high-resolution terminology.
- Evaluate an example of low-resolution terminology: Uncoupling was studied in stressed cells by measurement of coupled respiration, evaluation of uncoupled respiration after inhibition with oligomycin, and FCCP titration to quantify uncoupled respiration.
Bioblast alert 2011(01): 2011-11-11
- A key question on the separation of qualitative versus quantitative change of mitochondrial function is addressed in a new O2k-Publication. Does training induce mild uncoupling? Are sedentary humans healthy controls?
- ETS capacity plays a key role in such analyses, which cannot be achieved quantitatively without careful uncoupler titrations.
- Basal respiration - term of the month: a hallmark of high-resolution respirometry is a matching high-resolution terminology.
