high-resolution terminology - matching measurements at high-resolution

Residual oxygen consumption

Description

Residual oxygen consumption Rox — respiration in the ROX state — is due to oxidative side reactions remaining after inhibition of the electron transfer pathway (ET pathway) in mitochondrial preparations or living cells. Different conditions designated as ROX states (different combinations of inhibitors of CI, CII, CIII and CIV) may result in consistent or significantly different levels of oxygen consumption. Hence the best quantitative estimate of Rox has to be carefully evaluated. Mitochondrial respiration is frequently corrected for Rox as the baseline state. Then, total ROUTINE, LEAK respiration, OXPHOS or ET (R, L, P and E) respiration are distinguished from the corresponding Rox-corrected, mitochondrial (ET-pathway linked) fluxes: R(mt), L(mt), P(mt) and E(mt). Alternatively, R, L, P and E are defined as Rox-corrected rates, in contrast to total rates R´, L´, P´ and E´. When expressing Rox as a fraction of ET capacity (flux control ratio), total flux E´ (not corrected for Rox), should be taken as the reference. Rox may be related to, but is of course different from ROS production.

In previous editions, (including Gnaiger 2020 BEC MitoPathways), the REN state was not distinguished from the ROX state. However, in novel applications (Q-Module and NADH-Module), a distinction of these states is necessary. Care must be taken when assuming Ren as a substitute of Rox correction of mitochondrial respiration.

Abbreviation: ROX, Rox

Reference: BEC 2020.1, Electron-transfer-pathway state, Gnaiger 2020 BEC MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol

Residual oxygen consumption: a baseline correction of mitochondrial respiration

Gnaiger E (2020) Residual oxygen consumption: a baseline correction of mitochondrial respiration. Mitochondr Physiol Network (2016-01-28) last update 2020-11-11.

Oroboros (2020) MiPNet

Abstract: Residual oxygen consumption (Rox) is sometimes referred to as 'non-mitochondrial respiration'. This may be correct to a large extent, but is not entirely accurate. In a preparation of purified isolated mitochondria, a small but significant Rox is observed after appropriate correction for instrumental background oxygen flux. In this case, Rox is 'mitochondrial non-ET pathway' rather than ‘non-mitochondrial’ respiration. In permeabilized and living cells, Rox may be higher than in isolated mitochondria, and this increased part then would be a measurement of non-mitochondrial respiration. Keilin (1926) introduced and accurately defined the term residual respiration.

• O2k-Network Lab: AT Innsbruck Gnaiger E

Abbreviations

Previous editions (including Gnaiger 2020 BEC MitoPathways): ROX-corrected ROUTINE, LEAK respiration, OXPHOS or ET pathway (R, L, P and E) is distinguished from the corresponding apparent fluxes that are not corrected for ROX. Apparent fluxes (not corrected for ROX; R´, L´, P´ and E´) places the terminology into the conceptual context of physical chemistry (including kinetics), where e.g. apparent equilibrium constants, K_eq´ (apparent Michaelis-Menten kinetic constants, K_m´) are carefully distinguished from the less accessible (or inaccessible) 'true' constants, K_eq (K_m).

Mitochondrial physiology nomenclature: Despite the fact that the previously used system of abbreviations is linked to a conceptually consistent framework of physical chemistry, generalized applicability may gain from a shift to a pragmatic emphasis of the experimental context of mitochondrial physiology. Rox correction is a baseline correction, which may be evaluated by a direct measurement within an experimental assay, or by independent test experiments for critical evaluation of the best estimate for a particular Rox correction. The Rox correction, therefore, may be emphasized by labelling the Rox-corrected values as mitochondrial (mt) fluxes: R(mt), L(mt), P(mt) and E(mt). Unfortunately, the total R, L, P and E values in this mitochondrial physiology system carry opposite meanings to the physical chemistry system of terminology. Confusion may be avoided in this context by explicit abbreviations, R(total), L(total), P(total) and E(total). Such lengthy abbreviations are not really practical.

Agreement is required for paving the way towards consistent data reporting and managing a meaningful database (but agreement is not even reached in hot debates on caloric units [J versus cal] or frozen debates on commonly used temperature scales [°C versus Faraday]. Unfortunately, the two systems of abbreviations for Rox correction are not compatible. It is of practical importance to use short and well defined symbols. As a practical guideline, therefore, the simplest solution is to define in a given context, if data (and symbols used) refer to total or Rox-corrected results, and then use the simple symbols R, L, P and E in such a defined context.

Keilin 1929: Residual respiration

'KCN, H₂S and CO combine with some of the components of oxidase forming an inactive compound, with the result that cytochrome, or at least its components a’ and c’, as well as paraphenylenediamine added to the cells, are not oxidised. The respiratory process can be still carried out through the medium of some autoxidisable carriers such as haemochromogens, haematins, the component b’ of cytochrome, or some as yet unknown autoxidisable substances. This residual respiration, according to the nature of the cell, may represent a larger or smaller fraction of the total respiration of the cell.'

Keilin D (1929) Cytochrome and respiratory enzymes. Proc R Soc London Ser B 104:206-52.

Experimental tests on Rox

Is the preparation fully permeabilized?

Rox may be estimated in mitochondrial preparations in SUIT protocols which start at a respiratory state without added CHO substrates and without inhibitors, such that continuation of the SUIT protocol is possible for OXPHOS analysis. Some critical questions arise for evaluation, if this respiratory 'ROX state' represents a valid condition for estimation of Rox, and for comparison with Rox measured at the end of a SUIT protocol after titration of substrates and inhibitors of key elements of the electron transfer pathway (e.g. Rotenone, Malonate and Antimycin A as inhibitors of CI, CII and CIII). For evaluation of such an initial estimate of Rox, the following considerations are suggested.

A preparation of permeabilized tissue or cells, P_tic, may contain a fraction of living, non-permeabilized cells. Non-permeabilized cells have ROUTINE respiration that
1. is higher than Rox;
2. is not stimulated by addition of ADP;
3. is not diminished over prolonged periods of time due to the presence of cellular endogenous substrates;
4. can be stimulated by uncoupler titration;
5. can be inhibited by Rot (CI) and Ama (CIII), etc.
Respiration of permeabilized tissue or cells incubated in a medium with significant concentrations of mitochondrial substrates
1. is higher than Rox;
2. is stimulated by addition of ADP (compare 1.2);
3. is not diminished over prolonged periods of time due to the presence of exogenous substrates in the medium;
4. can be stimulated by uncoupler titration,
5. can be inhibited by Rot (CI) and Ama (CIII), etc.
In contrast, the acutal level of Rox of fully permeabilized cells responds to such tests as
1. Rox is obtained after gradual depletion of mitochondrial internal substrates (gradual decline of oxygen consumption);
2. ADP or uncoupler titrations accelerate this decline;
3. Rot and Ama do not inhibit Rox;
4. uncoupler titration does not stimulate Rox.

Keywords

```
The Blue Book 2020
```
OXPHOS-, ROUTINE-, ET-, and LEAK states; respiratory capacities (P, R, E, L) corrected for residual oxygen consumption Rox.
4-compartmental OXPHOS model. (1) ET capacity E of the noncoupled electron transfer system ETS. OXPHOS capacity P is partitioned into (2) the dissipative LEAK component L, and (3) ADP-stimulated P-L net OXPHOS capacity. (4) If P-L is kinetically limited by a low capacity of the phosphorylation system to utilize the protonmotive force pmF, then the apparent E-P excess capacity is available to drive coupled processes other than phosphorylation P» (ADP to ATP) without competing with P».
(P-L)/P is the OXPHOS P-L control efficiency. The biochemical coupling efficiency is independent of kinetic control by the phosphorylation system when expressed as the E-L coupling efficiency, (E-L)/E. (E-P)/E is the kinetic E-P control efficiency.

Bioblast links: Coupling control - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>

1. Mitochondrial and cellular respiratory rates in coupling-control states

» Baseline state

Respiratory rate	Defining relations
OXPHOS capacity	P = P´-Rox	mt-preparations
ROUTINE respiration	R = R´-Rox	living cells
ET capacity	E = E´-Rox	» Level flow
		» Noncoupled respiration - Uncoupler
LEAK respiration	L = L´-Rox	» Static head
		» LEAK state with ATP
		» LEAK state with oligomycin
		» LEAK state without adenylates
Residual oxygen consumption Rox	L = L´-Rox

Chance and Williams nomenclature: respiratory states

» State 1 —» State 2 —» State 3 —» State 4 —» State 5

2. Flux control ratios related to coupling in mt-preparations and living cells

» Flux control ratio

» Coupling-control ratio

» Coupling-control protocol

FCR	Definition
L/P coupling-control ratio	L/P	» Respiratory acceptor control ratio, RCR = P/L
L/R coupling-control ratio	L/R
L/E coupling-control ratio	L/E	» Uncoupling-control ratio, UCR = E/L (ambiguous)
P/E control ratio	P/E
R/E control ratio	R/E	» Uncoupling-control ratio, UCR = E/L
net P/E control ratio	(P-L)/E
net R/E control ratio	(R-L)/E

3. Net, excess, and reserve capacities of respiration

Respiratory net rate	Definition	Icon
P-L net OXPHOS capacity	P-L
R-L net ROUTINE capacity	R-L
E-L net ET capacity	E-L
E-P excess capacity	E-P
E-R reserve capacity	E-R

4. Flux control efficiencies related to coupling-control ratios

» Flux control efficiency j_Z-Y

» Background state

» Reference state

» Metabolic control variable

Coupling-control efficiency		Definition		Canonical term
P-L control efficiency	j_P-L	= (P-L)/P	= 1-L/P	P-L OXPHOS-flux control efficiency
R-L control efficiency	j_R-L	= (R-L)/R	= 1-L/R	R-L ROUTINE-flux control efficiency
E-L coupling efficiency	j_E-L	= (E-L)/E	= 1-L/E	E-L ET-coupling efficiency » Biochemical coupling efficiency
E-P control efficiency	j_E-P	= (E-P)/E	= 1-P/E	E-P ET-excess flux control efficiency
E-R control efficiency	j_E-R	= (E-R)/E	= 1-R/E	E-R ET-reserve flux control efficiency

5. General

» Basal respiration

» Cell ergometry

» Dyscoupled respiration

» Dyscoupling

» Electron leak

» Electron-transfer-pathway state

» Hyphenation

» Oxidative phosphorylation

» Oxygen flow

» Oxygen flux

» Permeabilized cells

» Phosphorylation system

» Proton leak

» Proton slip

» Respiratory state

» Uncoupling

References

Bioblast link	Reference	Year
Gnaiger 2009 Int J Biochem Cell Biol	Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41:1837-45. https://doi.org/10.1016/j.biocel.2009.03.013	2009
Gnaiger 2020 BEC MitoPathways	Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5^th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002	2020
BEC 2020.1 doi10.26124bec2020-0001.v1	Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1	2020
Keilin 1929 Proc R Soc London Ser B	Keilin D (1929) Cytochrome and respiratory enzymes. Proc R Soc London Ser B 104:206-52.	1929

» List of publications: Residual oxygen consumption

Sort in ascending/descending order by a click on one of the small symbols in squares below.
Default sorting: chronological. Empty fields appear first in ascending order.

	Year	Reference	Coupling	Pathway	Preparation	Organism	Tissue;cell
Shi 2024 Clin Sci (Lond)	2024	Shi L, Yang J, Tao Z, Zheng L, Bui TF, Alonso RL, Yue F, Cheng Z (2024) Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning. Clin Sci (Lond) 138:371-85. https://doi.org/10.1042/cs20230973	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Fibroblast
Xu 2024 Sci Adv	2024	Xu G, Quan S, Schell J, Gao Y, Varmazyad M, Sreenivas P, Cruz D, Jiang H, Pan M, Han X, Palavicini JP, Zhao P, Sun X, Marchant ED, Rasmussen BB, Li G, Katsumura S, Morita M, Munkácsy E, Horikoshi N, Chocron ES, Gius D (2024) Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty liver disease. Sci Adv 10:eadj5942. https://doi.org/10.1126/sciadv.adj5942	ET LEAK OXPHOS	F N ROX		Mouse	Liver
Navarro 2024 Exp Gerontol	2024	Navarro CDC, Francisco A, Costa EFD, Dalla Costa AP, Sartori MR, Bizerra PFV, Salgado AR, Figueira TR, Vercesi AE, Castilho RF (2024) Aging-dependent mitochondrial bioenergetic impairment in the skeletal muscle of NNT-deficient mice. Exp Gerontol 193:112465. https://doi.org/10.1016/j.exger.2024.112465	ET LEAK OXPHOS	N S CIV ROX	Permeabilized tissue	Mouse	Skeletal muscle
Liepinsh 2024 Br J Pharmacol	2024	Liepinsh E, Zvejniece L, Clemensson L, Ozola M, Vavers E, Cirule H, Korzh S, Skuja S, Groma V, Briviba M, Grinberga S, Liu W, Olszewski P, Gentreau M, Fredriksson R, Dambrova M, Schiöth HB (2024) Hydroxymethylglutaryl-CoA reductase activity is essential for mitochondrial β-oxidation of fatty acids to prevent lethal accumulation of long-chain acylcarnitines in the mouse liver. Br J Pharmacol [Epub ahead of print]. https://doi.org/10.1111/bph.16363	ET LEAK OXPHOS	F N S NS ROX	Homogenate	Mouse	Liver
Lhuissier 2024 iScience	2024	Lhuissier C, Desquiret-Dumas V, Girona A, Alban J, Faure J, Cassereau J, Codron P, Lenaers G, Baris OR, Gueguen N, Chevrollier A (2024) Mitochondrial F0F1-ATP synthase governs the induction of mitochondrial fission. iScience 27:109808. https://doi.org/10.1016/j.isci.2024.109808	LEAK ROUTINE OXPHOS ET	N NS ROX	Permeabilized cells Intact cells	Mouse	Fibroblast
Evinova 2024 J Bioenerg Biomembr	2024	Evinova A, Baranovicova E, Hajduchova D, Dibdiakova K, Baranova I, Racay P, Strnadel J, Pecova R, Halasova E, Pokusa M (2024) The impact of ATP-sensitive potassium channel modulation on mitochondria in a Parkinson's disease model using SH-SY5Y cells depends on their differentiation state. J Bioenerg Biomembr [Epub ahead of print]. https://doi.org/10.1007/s10863-024-10018-x	LEAK ROUTINE ET	S ROX	Intact cells	Human	Neuroblastoma
Garcia-Poyatos 2024 Dev Cell	2024	García-Poyatos C, Arora P, Calvo E, Marques IJ, Kirschke N, Galardi-Castilla M, Lembke C, Meer M, Fernández-Montes P, Ernst A, Haberthür D, Hlushchuk R, Vázquez J, Vermathen P, Enríquez JA, Mercader N (2024) Cox7a1 controls skeletal muscle physiology and heart regeneration through complex IV dimerization. Dev Cell [Epub ahead of print]. https://doi.org/10.1016/j.devcel.2024.04.012	LEAK OXPHOS	N S CIV NS ROX	Isolated mitochondria	Zebrafish	Skeletal muscle
Jacovetti 2024 Mol Metab	2024	Jacovetti C, Donnelly C, Menoud V, Suleiman M, Cosentino C, Sobel J, Wu K, Bouzakri K, Marchetti P, Guay C, Kayser B, Regazzi R (2024) The mitochondrial tRNA-derived fragment, mt-tRF-Leu^TAA, couples mitochondrial metabolism to insulin secretion. Mol Metab 84:101955. https://doi.org/10.1016/j.molmet.2024.101955	LEAK OXPHOS	N S NS ROX	Permeabilized cells	Rat	Islet cell;pancreas;thymus
Hu 2024 Ecotoxicol Environ Saf	2024	Hu R, Fan W, Li S, Zhang G, Zang L, Qin L, Li R, Chen R, Zhang L, Gu W, Zhang Y, Rajagopalan S, Sun Q, Liu C (2024) PM_2.5-induced cellular senescence drives brown adipose tissue impairment in middle-aged mice. Ecotoxicol Environ Saf 278:116423. https://doi.org/10.1016/j.ecoenv.2024.116423	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Mouse	Fat
Mahapatra 2024 J Gerontol A Biol Sci Med Sci	2024	Mahapatra G, Gao Z, Bateman JR 3rd, Lockhart SN, Bergstrom J, Piloso JE, Craft S, Molina AJA (2024) Peripheral blood cells from older adults exhibit sex-associated differences in mitochondrial function. J Gerontol A Biol Sci Med Sci [Epub ahead of print]. https://doi.org/10.1093/gerona/glae098	ROUTINE OXPHOS ET	F N Gp CIV NS Other combinations ROX	Permeabilized cells Intact cells	Human	Blood cells
Song 2024 Commun Biol	2024	Song A, Zhao N, Hilpert DC, Perry C, Baur JA, Wallace DC, Schaefer PM (2024) Visualizing subcellular changes in the NAD(H) pool size versus redox state using fluorescence lifetime imaging microscopy of NADH. Commun Biol 7:428. https://doi.org/10.1038/s42003-024-06123-7	LEAK ROUTINE ET	ROX	Intact cells	Human	HEK
Hunter-Manseau 2024 Insect Sci	2024	Hunter-Manseau F, Cormier SB, Strang R, Pichaud N (2024) Fasting as a precursor to high-fat diet enhances mitochondrial resilience in Drosophila melanogaster. Insect Sci [Epub ahead of print]. https://doi.org/10.1111/1744-7917.13355	LEAK OXPHOS ET	N S Gp NS Other combinations ROX	Permeabilized tissue	Drosophila
Lavorato 2024 JCI Insight	2024	Lavorato M, Iadarola D, Remes C, Kaur P, Broxton C, Mathew ND, Xiao R, Seiler C, Nakamaru-Ogiso E, Anderson VE, Falk MJ (2024) dldhcri3 zebrafish exhibited altered mitochondrial ultrastructure, morphology and dysfunction partially rescued by probucol or thiamine. JCI Insight [Epub ahead of print]. https://doi.org/10.1172/jci.insight.178973	ET LEAK ROUTINE OXPHOS	N S NS ROX CIV	Homogenate	Zebrafish
Tsouka 2024 Commun Med (Lond)	2024	Tsouka S, Kumar P, Seubnooch P, Freiburghaus K, St-Pierre M, Dufour JF, Masoodi M (2024) Transcriptomics-driven metabolic pathway analysis reveals similar alterations in lipid metabolism in mouse MASH model and human. Commun Med (Lond) 4:39. https://doi.org/10.1038/s43856-024-00465-3	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Liver
Torcasio 2024 J Transl Med	2024	Torcasio R, Gallo Cantafio ME, Veneziano C, De Marco C, Ganino L, Valentino I, Occhiuzzi MA, Perrotta ID, Mancuso T, Conforti F, Rizzuti B, Martino EA, Gentile M, Neri A, Viglietto G, Grande F, Amodio N (2024) Targeting of mitochondrial fission through natural flavanones elicits anti-myeloma activity. J Transl Med 22:208. https://doi.org/10.1186/s12967-024-05013-0	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Romagnolo 2024 Acta Neuropathol	2024	Romagnolo A, Dematteis G, Scheper M, Luinenburg MJ, Mühlebner A, Van Hecke W, Manfredi M, De Giorgis V, Reano S, Filigheddu N, Bortolotto V, Tapella L, Anink JJ, François L, Dedeurwaerdere S, Mills JD, Genazzani AA, Lim D, Aronica E (2024) Astroglial calcium signaling and homeostasis in tuberous sclerosis complex. Acta Neuropathol 147:48. https://doi.org/10.1007/s00401-024-02711-3	LEAK ROUTINE ET	ROX	Intact cells	Human	Nervous system
Cefis 2024 Acta Physiol (Oxf)	2024	Cefis M, Dargegen M, Marcangeli V, Taherkhani S, Dulac M, Leduc-Gaudet JP, Mayaki D, Hussain SNA, Gouspillou G (2024) MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H₂O₂ emission. Acta Physiol (Oxf) [Epub ahead of print]. https://doi.org/10.1111/apha.14119	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Donnelly 2024 Redox Biol	2024	Donnelly C, Komlódi T, Cecatto C, Cardoso LHD, Compagnion A-C, Matera A, Tavernari D, Campiche O, Paolicelli RC, Zanou N, Kayser B, Gnaiger E, Place N (2024) Functional hypoxia reduces mitochondrial calcium uptake. Redox Biol 71:103037. https://doi.org/10.1016/j.redox.2024.103037	LEAK OXPHOS ET	N S NS ROX	Intact organism Isolated mitochondria Intact cells	Human Mouse	Heart Skeletal muscle
Meszaros 2024 Transpl Int	2024	Meszaros AT, Weissenbacher A, Schartner M, Egelseer-Bruendl T, Hermann M, Unterweger J, Mittelberger C, Reyer BA, Hofmann J, Zelger BG, Hautz T, Resch T, Margreiter C, Maglione M, Komlódi T, Ulmer H, Cardini B, Troppmair J, Öfner D, Gnaiger E, Schneeberger S, Oberhuber R (2024) The predictive value of graft viability and bioenergetics testing towards the outcome in liver transplantation. Transpl Int 37:12380. https://doi.org/10.3389/ti.2024.12380	LEAK OXPHOS ET	N S NS F ROX	Homogenate	Human	Liver
Hu 2024 Front Endocrinol (Lausanne)	2024	Hu Y, Fang B, Tian X, Wang H, Tian X, Yu F, Li T, Yang Z, Shi R (2024) Passive exercise is an effective alternative to HRT for restoring OVX induced mitochondrial dysfunction in skeletal muscle. Front Endocrinol (Lausanne) 15:1356312. https://doi.org/10.3389/fendo.2024.1356312	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Al-Sabri 2024 Sci Rep	2024	Al-Sabri MH, Ammar N, Korzh S, Alsehli AM, Hosseini K, Fredriksson R, Mwinyi J, Williams MJ, Boukhatmi H, Schiöth HB (2024) Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes. https://doi.org/10.1038/s41598-024-53446-w	LEAK OXPHOS ET	F N S Gp NS ROX	Permeabilized tissue	Drosophila	Skeletal muscle
Fitzgerald 2024 J Cachexia Sarcopenia Muscle	2024	Fitzgerald LF, Lackey J, Moussa A, Shah SV, Castellanos AM, Khan S, Schonk M, Thome T, Salyers ZR, Jakkidi N, Kim K, Yang Q, Hepple RT, Ryan TE (2024) Chronic aryl hydrocarbon receptor activity impairs muscle mitochondrial function with tobacco smoking. https://doi.org/10.1002/jcsm.13439	LEAK OXPHOS	N CIV NS ROX	Permeabilized tissue Isolated mitochondria	Mouse	Skeletal muscle
Lin 2024 Apoptosis	2024	Lin HY, Liang CJ, Yang MY, Chen PL, Wang TM, Chen YH, Shih YH, Liu W, Chiu CC, Chiang CK, Lin CS, Lin HC (2024) Critical roles of tubular mitochondrial ATP synthase dysfunction in maleic acid-induced acute kidney injury. https://doi.org/10.1007/s10495-023-01897-3	LEAK ROUTINE ET	ROX	Intact cells	Human	Kidney
Abegg 2024 Toxicol Lett	2024	Abegg VF, Panajatovic MV, Mancuso RV, Allard JA, Duthaler U, Odermatt A, Krähenbühl S, Bouitbir J (2024) Mechanisms of hepatocellular toxicity associated with the components of St. John's Wort extract hypericin and hyperforin in HepG2 and HepaRG cells. https://doi.org/10.1016/j.toxlet.2024.01.008	LEAK ROUTINE OXPHOS ET	N S DQ CIV ROX	Permeabilized cells Intact cells	Human	Liver
Westerlund 2024 Heliyon	2024	Westerlund E, Marelsson SE, Karlsson M, Sjövall F, Chamkha I, Åsander Frostner E, Lundgren J, Fellman V, Eklund EA, Steding-Ehrenborg K, Darin N, Paul G, Hansson MJ, Ehinger JK, Elmér E (2024) Correlation of mitochondrial respiration in platelets, peripheral blood mononuclear cells and muscle fibers. Heliyon 10:e26745. https://doi.org/10.1016/j.heliyon.2024.e26745	ET LEAK ROUTINE OXPHOS	N S CIV NS ROX	Permeabilized cells Permeabilized tissue Intact cells	Human	Skeletal muscle Blood cells Platelet
Huang 2024 Cell Mol Life Sci	2024	Huang Y, Yang Y, Chen X, Zeng S, Chen Y, Wang H, Lv X, Hu X, Teng L (2024) Downregulation of malic enzyme 3 facilitates progression of gastric carcinoma via regulating intracellular oxidative stress and hypoxia-inducible factor-1α stabilization. Cell Mol Life Sci 81:375. https://doi.org/10.1007/s00018-024-05388-9	ET LEAK ROUTINE	ROX	Intact cells
Kahl 2024 J Hepatol	2024	Kahl S, Straßburger K, Pacini G, Trinks N, Pafili K, Mastrototaro L, Dewidar B, Sarabhai T, Trenkamp S, Esposito I, Schlensak M, Granderath FA, Roden M (2024) Dysglycemia and liver lipid content determine the relationship of insulin resistance with hepatic OXPHOS capacity in obesity. J Hepatol [Epub ahead of print]. https://doi.org/10.1016/j.jhep.2024.08.012	OXPHOS ET LEAK	F N S ROX	Permeabilized tissue	Human	Liver
Benayada 2024 J Funct Foods	2024	Benayada L, Gubitosa F, Fraternale D, Carloni S, Cerioni L, Matacchione G, Olivieri F, Potenza L, De Bellis R, Chiarantini L, Roselli C, Valentini L, Gobbi P, Balduini W, Pappagallo N, Ventura N, Kass GEN, Colomba M, Albertini MC (2024) In vitro anti-inflammatory activity of Malus × domestica var. Mela Rosa Marchigiana pulp callus extract contrasting high glucose conditions. J Funct Foods 121:106420. https://doi.org/10.1016/j.jff.2024.106420	ET LEAK ROUTINE	ROX	Intact cells	Human	Other cell lines
Fernandez-Tocino 2024 Basic Res Cardiol	2024	Fernández-Tocino M, Pun-Garcia A, Gómez M, Clemente-Moragón A, Oliver E, Villena-Gutierrez R, Trigo-Anca S, Díaz-Guerra A, Sanz-Rosa D, Prados B, Del Campo L, Andrés V, Fuster V, de la Pompa JL, Cádiz L, Ibañez B (2024) β3-Adrenergic receptor overexpression in cardiomyocytes preconditions mitochondria to withstand ischemia-reperfusion injury. Basic Res Cardiol [Epub ahead of print]. https://doi.org/10.1007/s00395-024-01072-y	ET LEAK OXPHOS	N ROX	Isolated mitochondria	Mouse	Heart
Liu 2024 Cell Death Dis	2024	Liu JC, Zhao XY, Wu ML, Shi YF, Huang ZP, Fang LP, Zhu C, Peng X, Shi ZL, Lan LJ, Ji WL, Luo L, Feng L, Zhang ZL, Xu DE, Li S, Qin ZH, Sun YY, Schachner M, Ma QH (2024) GPR50 regulates neuronal development as a mitophagy receptor. Cell Death Dis 15:591. https://doi.org/10.1038/s41419-024-06978-y	ET LEAK OXPHOS	N S CIV NS ROX	Homogenate	Mouse	Nervous system
Cazares-Preciado 2024 BMJ Open Diabetes Res Care	2024	Cázares-Preciado JA, López-Arredondo A, Cruz-Cardenas JA, Luévano-Martínez LA, García-Rivas G, Prado-Garcia H, Brunck MEG (2024) Metabolic features of neutrophilic differentiation of HL-60 cells in hyperglycemic environments. BMJ Open Diabetes Res Care 12:e004181. https://doi.org/10.1136/bmjdrc-2024-004181	LEAK ROUTINE OXPHOS	ROX	Intact cells	Human	Blood cells
Tagliafico 2024 Aging Cell	2024	Tagliafico L, Da Costa RT, Boccia L, Kavehmoghaddam S, Ramirez B, Tokarska-Schlattner M, Scoma ER, Hambardikar V, Bonfiglio T, Caffa I, Monacelli F, Schlattner U, Betley JN, Nencioni A, Solesio ME (2024) Short-term starvation activates AMPK and restores mitochondrial inorganic polyphosphate, but fails to reverse associated neuronal senescence. Aging Cell [Epub ahead of print]. https://doi.org/10.1111/acel.14289	ET LEAK ROUTINE	ROX	Intact cells	Human	Neuroblastoma
Sartori 2024 Pediatr Res	2024	Sartori LF, Tsemberis E, Hernandez T, Luchette K, Zhang D, Farooqi S, Bush J, McCann JC, Balamuth F, Weiss SL (2024) Distinct mitochondrial respiration profiles in pediatric patients with febrile illness versus sepsis. Pediatr Res [Epub ahead of print]. https://doi.org/10.1038/s41390-024-03420-z	ET LEAK ROUTINE	ROX	Intact cells	Human	Blood cells
Doerrier 2024 Free Radic Biol Med	2024	Doerrier C, Gama-Perez P, Pesta D, Distefano G, Soendergaard SD, Maise Chroeis K, Gonzalez-Franquesa A, Goodpaster BH, Prats C, Sales-Pardo M, Guimera R, Coen PM, Gnaiger E, Larsen S, Garcia-Roves PM (2024) Harmonization of experimental procedures to assess mitochondrial respiration in human permeabilized skeletal muscle fibers. Free Radic Biol Med 223:384-97. https://doi.org/10.1016/j.freeradbiomed.2024.07.039	ET LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Leo 2024 MitoFit	2024	Leo E, Rychtarova L, Garcia-Souza LF, Åsander Frostner E, Elmér E, Gnaiger E (2024) High-resolution respirometry in a small-volume chamber. MitoFit Preprints 2024.4.v2. https://doi.org/10.26124/mitofit:2024-0004.v2	ET LEAK ROUTINE OXPHOS	F N S Gp CIV NS Other combinations ROX	Permeabilized cells Homogenate Isolated mitochondria Intact cells	Human Mouse	Heart Nervous system Blood cells HUVEC Platelet
Magri 2024 Cell Death Discov	2024	Magrì A, Lipari CLR, Caccamo A, Battiato G, Conti Nibali S, De Pinto V, Guarino F, Messina A (2024) AAV-mediated upregulation of VDAC1 rescues the mitochondrial respiration and sirtuins expression in a SOD1 mouse model of inherited ALS. Cell Death Discov 10:178. https://doi.org/10.1038/s41420-024-01949-w	ET LEAK OXPHOS	N S NS ROX	Homogenate	Mouse	Nervous system
Artman 2024 J Equine Vet Sci	2024	Artman JL, Wesolowski LT, Semanchik PL, Isles JK, Norton SA, White-Springer SH (2024) Local and systemic responses to repeated gluteal muscle microbiopsies in mature sedentary horses. J Equine Vet Sci 136:105070. https://doi.org/10.1016/j.jevs.2024.105070	ET LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Horse	Skeletal muscle
Tabara 2024 Cell	2024	Tábara LC, Burr SP, Frison M, Chowdhury SR, Paupe V, Nie Y, Johnson M, Villar-Azpillaga J, Viegas F, Segawa M, Anand H, Petkevicius K, Chinnery PF, Prudent J (2024) MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels. Cell [Epub ahead of print]. https://doi.org/10.1016/j.cell.2024.05.017	ET LEAK ROUTINE	ROX	Intact cells	Human
Dulac 2024 J Physiol	2024	Dulac M, Hajj-Boutros G, Sonjak V, Faust A, Hussain SNA, Chevalier S, Dionne IJ, Morais JA, Gouspillou G (2024) A multimodal exercise countermeasure prevents the negative impact of head-down tilt bed rest on muscle volume and mitochondrial health in older adults. J Physiol [Epub ahead of print]. https://doi.org/10.1113/jp285897	LEAK OXPHOS	F N NS ROX	Permeabilized tissue	Human	Skeletal muscle
Lorito 2024 EMBO Mol Med	2024	Lorito N, Subbiani A, Smiriglia A, Bacci M, Bonechi F, Tronci L, Romano E, Corrado A, Longo DL, Iozzo M, Ippolito L, Comito G, Giannoni E, Meattini I, Avgustinova A, Chiarugi P, Bachi A, Morandi A (2024) FADS1/2 control lipid metabolism and ferroptosis susceptibility in triple-negative breast cancer. EMBO Mol Med [Epub ahead of print]. https://doi.org/10.1038/s44321-024-00090-6	ET LEAK ROUTINE	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Brunner 2024 Life Sci Alliance	2024	Brunner S, Höring M, Liebisch G, Schweizer S, Scheiber J, Giansanti P, Hidrobo M, Hermeling S, Oeckl J, Prudente de Mello N, Perocchi F, Seeliger C, Strohmeyer A, Klingenspor M, Plagge J, Küster B, Burkhardt R, Janssen KP, Ecker J (2024) Mitochondrial lipidomes are tissue specific - low cholesterol contents relate to UCP1 activity. Life Sci Alliance 7:e202402828. https://doi.org/10.26508/lsa.202402828	ET LEAK	N Gp ROX	Isolated mitochondria	Mouse	Fat
Morishita 2024 Biol Pharm Bull	2024	Morishita R, Onishi A, Oya M, Karashima H, Mori M, Kawatani Y, Kamei N, Takeda-Morishita M (2024) Effect of orally ingested water containing H2-filled ultrafine bubbles (UFBs) on ethanol-induced oxidative stress in rats. Biol Pharm Bull 47:1106-12. https://doi.org/10.1248/bpb.b24-00034	ET LEAK OXPHOS	N S NS ROX	Homogenate	Rat	Liver
Wilburn 2024 Sci Rep	2024	Wilburn D, Miserlis D, Fletcher E, Papoutsi E, Ismaeel A, Bradley C, Ring A, Wilkinson T, Smith RS, Ferrer L, Haynatzki G, Monteleone P, Banerjee S, Brisbois E, Bohannon WT, Koutakis P (2024) Skeletal muscle desmin alterations following revascularization in peripheral artery disease claudicants. Sci Rep 14:12609. https://doi.org/10.1038/s41598-024-63626-3	LEAK OXPHOS	N S DQ CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Alvarez-Sanchez 2024 Cell Mol Life Sci	2024	Álvarez-Sánchez A, Grinat J, Doria-Borrell P, Mellado-López M, Pedrera-Alcócer É, Malenchini M, Meseguer S, Hemberger M, Pérez-García V (2024) The GPI-anchor biosynthesis pathway is critical for syncytiotrophoblast differentiation and placental development. Cell Mol Life Sci 81:246. https://doi.org/10.1007/s00018-024-05284-2	ET LEAK ROUTINE	ROX	Intact cells	Mouse	Stem cells
Zhao 2024 J Adv Res	2024	Zhao Y, Lu Z, Zhang H, Wang L, Sun F, Li Q, Cao T, Wang B, Ma H, You M, Zhou Q, Wei X, Li L, Liao Y, Yan Z, Liu D, Gao P, Zhu Z (2024) Sodium-glucose exchanger 2 inhibitor canagliflozin promotes mitochondrial metabolism and alleviates salt-induced cardiac hypertrophy via preserving SIRT3 expression. J Adv Res [Epub ahead of print]. https://doi.org/10.1016/j.jare.2024.04.030	ET LEAK OXPHOS	F N S NS ROX	Isolated mitochondria	Mouse	Heart
Wang 2024 J Biomed Sci	2024	Wang V, Tseng KY, Kuo TT, Huang EY, Lan KL, Chen ZR, Ma KH, Greig NH, Jung J, Choi HI, Olson L, Hoffer BJ, Chen YH (2024) Attenuating mitochondrial dysfunction and morphological disruption with PT320 delays dopamine degeneration in MitoPark mice. J Biomed Sci 31:38. https://doi.org/10.1186/s12929-024-01025-6	ET LEAK OXPHOS	N S CIV NS ROX	Homogenate	Mouse	Nervous system
Kankuri 2023 Exp Mol Med	2023	Kankuri E, Finckenberg P, Leinonen J, Tarkia M, Björk S, Purhonen J, Kallijärvi J, Kankainen M, Soliymani R, Lalowski M, Mervaala E (2023) Altered acylcarnitine metabolism and inflexible mitochondrial fuel utilization characterize the loss of neonatal myocardial regeneration capacity. https://doi.org/10.1038/s12276-023-00967-5	LEAK OXPHOS	F N S NS ROX	Isolated mitochondria	Mouse	Heart
Giovarelli 2023 Mol Med	2023	Giovarelli M, Serati A, Zecchini S, Guelfi F, Clementi E, Mandò C (2023) Cryopreserved placental biopsies maintain mitochondrial activity for high-resolution respirometry. https://doi.org/10.1186/s10020-023-00645-2	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Human	Genital
Cruz-Gregorio 2023 Phytother Res	2023	Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Medina-Campos ON, Sciutto E, Fragoso G, Pedraza-Chaverri J (2023) α-Mangostin induces oxidative damage, mitochondrial dysfunction, and apoptosis in a triple-negative breast cancer model. https://doi.org/10.1002/ptr.7812	LEAK ROUTINE ET	ROX CIV	Intact cells	Mouse	Endothelial;epithelial;mesothelial cell
Oliveira 2023 J Biol Chem	2023	Oliveira AG, Oliveira LD, Cruz MV, Guimarães DSPSF, Lima TI, BC Santos-Fávero, Luchessi AD, BA Pauletti, Leme AP, Bajgelman MC, Afonso J, Regitano LCA, Carvalho HF, Carneiro EM, Kobarg J, Perissi V, Auwerx J, Silveira LR (2023) Interaction between poly-A binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response. https://doi.org/10.1016/j.jbc.2023.104702	LEAK ROUTINE ET	ROX	Intact cells
Scandalis 2023 JAMA Cardiol	2023	Scandalis L, Kitzman DW, Nicklas BJ, Lyles M, Brubaker P, Nelson MB, Gordon M, Stone J, Bergstrom J, Neufer PD, Gnaiger E, Molina AJA (2023) Skeletal muscle mitochondrial respiration and exercise intolerance in patients with heart failure with preserved ejection fraction. JAMA Cardiol 8:575–84. https://doi.org/10.1001/jamacardio.2023.0957	OXPHOS ET LEAK	N NS ROX S	Permeabilized tissue	Human	Skeletal muscle
Moellering 2023 Arthritis Res Ther	2023	Moellering DR, Smith-Johnston K, Kelley C, Sammy MJ, Benedict J, Brock G, Johnson J, Baskin KK, Jarjour WN, Belury MA, Reiser PJ, Nagareddy PR, Hanaoka BY (2023) Association between skeletal muscle mitochondrial dysfunction and insulin resistance in patients with rheumatoid arthritis: a case-control study. https://doi.org/10.1186/s13075-023-03065-z	LEAK OXPHOS ET	F N CIV ROX	Permeabilized tissue	Human	Skeletal muscle
Bellar 2023 Clin Transl Med	2023	Bellar A, Welch N, Dasarathy J, Attaway A, Musich R, Kumar A, Sekar J, Mishra S, Sandlers Y, Streem D, Nagy LE, Dasarathy S (2023) Peripheral blood mononuclear cell mitochondrial dysfunction in acute alcohol-associated hepatitis. https://doi.org/10.1002/ctm2.1276	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Blood cells
Kienzle 2023 BMC Biol	2023	Kienzle L, Bettinazzi S, Choquette T, Brunet M, Khorami HH, Jacques JF, Moreau M, Roucou X, Landry CR, Angers A, Breton S (2023) A small protein coded within the mitochondrial canonical gene nd4 regulates mitochondrial bioenergetics. https://doi.org/10.1186/s12915-023-01609-y	LEAK ROUTINE OXPHOS ET	N CIV NS ROX	Permeabilized cells Intact cells	Human	HEK HeLa
Czyzowska 2023 Redox Biol	2023	Czyżowska A, Brown J, Xu H, Sataranatarajan K, Kinter M, Tyrell VJ, O'Donnell VB, Van Remmen H (2023) Elevated phospholipid hydroperoxide glutathione peroxidase (GPX4) expression modulates oxylipin formation and inhibits age-related skeletal muscle atrophy and weakness. https://doi.org/10.1016/j.redox.2023.102761	LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Silaidos 2023 Geroscience	2023	Silaidos CV, Reutzel M, Wachter L, Dieter F, Ludin N, Blum WF, Wudy SA, Matura S, Pilatus U, Hattingen E, Pantel J, Eckert GP (2023) Age-related changes in energy metabolism in peripheral mononuclear blood cells (PBMCs) and the brains of cognitively healthy seniors. https://doi.org/10.1007/s11357-023-00810-9	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Blood cells
Nollet 2023 Eur Heart J	2023	Nollet EE, Duursma I, Rozenbaum A, Eggelbusch M, Wüst RCI, Schoonvelde SAC, Michels M, Jansen M, van der Wel NN, Bedi KC, Margulies KB, Nirschl J, Kuster DWD, van der Velden J (2023) Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration. https://doi.org/10.1093/eurheartj/ehad028	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Heart
Stampley 2023 Physiol Rep	2023	Stampley JE, Cho E, Wang H, Theall B, Johannsen NM, Spielmann G, Irving BA (2023) Impact of maximal exercise on immune cell mobilization and bioenergetics. https://doi.org/10.14814/phy2.15753	LEAK ROUTINE OXPHOS ET	N NS ROX	Permeabilized cells Intact cells	Human	Blood cells
Gonnot 2023 Nat Commun	2023	Gonnot F, Boulogne L, Brun C, Dia M, Gouriou Y, Bidaux G, Chouabe C, Crola Da Silva C, Ducreux S, Pillot B, Kaczmarczyk A, Leon C, Chanon S, Perret C, Sciandra F, Dargar T, Gache V, Farhat F, Sebbag L, Bochaton T, Thibault H, Ovize M, Paillard M, Gomez L (2023) SERCA2 phosphorylation at serine 663 is a key regulator of Ca²⁺ homeostasis in heart diseases. https://doi.org/10.1038/s41467-023-39027-x	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Heart
Mendoza-Fuentes 2023 PeerJ	2023	Mendoza-Fuentes A, González-Burgos E, Aparicio Trejo OE, Delgado-Lamas G, Rodríguez-Chávez JL, Pedraza-Chaverri J, Gómez-Serranillos MP, Araiza-Olivera D (2023) The cytotoxicity effect of 7-hydroxy-3,4-dihydrocadalene from Heterotheca inuloides and semisynthetic cadalenes derivates towards breast cancer cells: involvement of oxidative stress-mediated apoptosis. https://doi.org/10.7717/peerj.15586	LEAK ROUTINE	ROX	Intact cells	Human
Mayayo-Vallverdu 2023 Redox Biol	2023	Mayayo-Vallverdú C, López de Heredia M, Prat E, González L, Espino Guarch M, Vilches C, Muñoz L, Asensi MA, Serra C, Llebaria A, Casado M, Artuch R, Garrabou G, Garcia-Roves PM, Pallardó FV, Nunes V (2023) The antioxidant l-Ergothioneine prevents cystine lithiasis in the Slc7a9^-/- mouse model of cystinuria. https://doi.org/10.1016/j.redox.2023.102801	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Kidney
Martell 2023 Acta Neuropathol Commun	2023	Martell E, Kuzmychova H, Senthil H, Kaul E, Chokshi CR, Venugopal C, Anderson CM, Singh SK, Sharif T (2023) Compensatory cross-talk between autophagy and glycolysis regulates senescence and stemness in heterogeneous glioblastoma tumor subpopulations. https://doi.org/10.1186/s40478-023-01604-y	LEAK ROUTINE ET	ROX	Intact cells	Human	Nervous system
Godtliebsen 2023 Autophagy	2023	Godtliebsen G, Larsen KB, Bhujabal Z, Opstad IS, Nager M, Punnakkal AR, Kalstad TB, Olsen R, Lund T, Prasad DK, Agarwal K, Myrmel T, Birgisdottir AB (2023) High-resolution visualization and assessment of basal and OXPHOS-induced mitophagy in H9c2 cardiomyoblasts. https://doi.org/10.1080/15548627.2023.2230837	LEAK ROUTINE ET	ROX	Intact cells	Rat	Heart
Golomb 2023 Sci Rep	2023	Golomb BA, Sanchez Baez R, Schilling JM, Dhanani M, Fannon MJ, Berg BK, Miller BJ, Taub PR, Patel HH (2023) Mitochondrial impairment but not peripheral inflammation predicts greater Gulf War illness severity. https://doi.org/10.1038/s41598-023-35896-w	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Antona 2023 Cell Death Discov	2023	Antona A, Leo G, Favero F, Varalda M, Venetucci J, Faletti S, Todaro M, Mazzucco E, Soligo E, Saglietti C, Stassi G, Manfredi M, Pelicci G, Corà D, Valente G, Capello D (2023) Targeting lysine-specific demethylase 1 (KDM1A/LSD1) impairs colorectal cancer tumorigenesis by affecting cancer cells stemness, motility, and differentiation. https://doi.org/10.1038/s41420-023-01502-1	LEAK ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Fletcher 2023 Transl Res	2023	Fletcher E, Miserlis D, Sorokolet K, Wilburn D, Bradley C, Papoutsi E, Wilkinson T, Ring A, Ferrer L, Haynatzki G, Smith RS, Bohannon WT, Koutakis P (2023) Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease. https://doi.org/10.1016/j.trsl.2023.05.002	LEAK OXPHOS	N S DQ CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Sathiaseelan 2023 J Gerontol A Biol Sci Med Sci	2023	Sathiaseelan R, Ahn B, Stout MB, Logan S, Wanagat J, Van M Nguyen H, Hord NG, Vandiver AR, Selvarani R, Ranjit R, Yarbrough H, Masingale A, Miller BF, Wolf RF, Austad SN, Richardson A (2023) A genetically heterogeneous rat model with divergent mitochondrial genomes. https://doi.org/10.1093/gerona/glad056	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Rat	Skeletal muscle
Thoral 2023 J Exp Biol	2023	Thoral E, Roussel D, Gasset E, Dutto G, Queiros Q, McKenzie DJ, Bourdeix JH, Metral L, Saraux C, Teulier L (2023) Temperature-dependent metabolic consequences of food deprivation in the European sardine. https://doi.org/10.1242/jeb.244984	LEAK OXPHOS	N NS ROX	Intact cells	Fishes	Skeletal muscle
Wu 2023 Int Immunopharmacol	2023	Wu F, Zhang YT, Teng F, Li HH, Guo SB (2023) S100a8/a9 contributes to sepsis-induced cardiomyopathy by activating ERK1/2-Drp1-mediated mitochondrial fission and respiratory dysfunction. https://doi.org/10.1016/j.intimp.2023.109716	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Heart
Dominguez-Lopez 2023 Neuropharmacology	2023	Dominguez-Lopez S, Ahn B, Sataranatarajan K, Ranjit R, Premkumar P, Van Remmen H, Beckstead MJ (2023) Long-term methamphetamine self-administration increases mesolimbic mitochondrial oxygen consumption and decreases striatal glutathione. https://doi.org/10.1016/j.neuropharm.2023.109436	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Nervous system
Gautam 2023 Neurobiol Dis	2023	Gautam M, Genç B, Helmold B, Ahrens A, Kuka J, Makrecka-Kuka M, Günay A, Koçak N, Aguilar-Wickings IR, Keefe D, Zheng G, Swaminathan S, Redmon M, Zariwala HA, Özdinler PH (2023) SBT-272 improves TDP-43 pathology in ALS upper motor neurons by modulating mitochondrial integrity, motility, and function. https://doi.org/10.1016/j.nbd.2023.106022	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue Homogenate	Rat	Heart Nervous system
Mahmoud 2023 Pharmacol Res	2023	Mahmoud AM, Kostrzewa M, Marolda V, Cerasuolo M, Maccarinelli F, Coltrini D, Rezzola S, Giacomini A, Mollica MP, Motta A, Paris D, Zorzano A, Marzo VD, Ronca R, Ligresti A (2023) Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer. https://doi.org/10.1016/j.phrs.2023.106683	LEAK	N S NS ROX	Permeabilized cells	Mouse	Endothelial;epithelial;mesothelial cell
Mioc 2023 Molecules	2023	Mioc M, Mioc A, Racoviceanu R, Ghiulai R, Prodea A, Milan A, Barbu Tudoran L, Oprean C, Ivan V, Șoica C (2023) The antimelanoma biological assessment of triterpenic acid functionalized gold nanoparticles. https://doi.org/10.3390/molecules28010421	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell
Fisar 2023 Biomedicines	2023	Fišar Z, Hroudová J, Zvěřová M, Jirák R, Raboch J, Kitzlerová E (2023) Age-dependent alterations in platelet mitochondrial respiration. https://doi.org/10.3390/biomedicines11061564	LEAK ROUTINE ET	ROX	Intact cells	Human	Platelet
Nord 2023 FASEB J	2023	Nord A, Chamkha I, Elmér E (2023) A whole blood approach improves speed and accuracy when measuring mitochondrial respiration in intact avian blood cells. https://doi.org/10.1096/fj.202201749r	LEAK ROUTINE ET	ROX	Intact cells	Birds	Blood cells
Gong 2023 Biomed Pharmacother	2023	Gong DF, Sun SC, Wang RR, Dawuti A, Kong DW, Liu RQ, Du LD, Wang SB, Lu Y, Yuan TY, Du GH, Fang LH (2023) Salvianolic acid A improve mitochondrial respiration and cardiac function via inhibiting apoptosis pathway through CRYAB in diabetic cardiomyopathy. https://doi.org/10.1016/j.biopha.2023.114382	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Heart
Horvath 2023 Antioxidants (Basel)	2023	Horváth T, Sándor L, Baráth B, Donka T, Baráth B, Mohácsi Á, Jász KD, Hartmann P, Boros M (2023) Methane admixture protects liver mitochondria and improves graft function after static cold storage and reperfusion. Antioxidants (Basel) 12:271. https://doi.org/10.3390/antiox12020271	LEAK OXPHOS	N NS ROX	Homogenate	Rat	Liver
Robertson 2023 J Cell Sci	2023	Robertson GL, Riffle S, Patel M, Bodnya C, Marshall A, Beasley HK, Garza-Lopez E, Shao J, Vue Z, Hinton A, Stoll MS, de Wet S, Theart RP, Chakrabarty RP, Loos B, Chandel NS, Mears JA, Gama V (2023) DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs. https://doi.org/10.1242/jcs.260370	LEAK ROUTINE OXPHOS ET	F N S DQ CIV NS ROX	Permeabilized cells Intact cells	Human	Fibroblast
Duran-Gueell 2023 FASEB J	2023	Duran-Güell M, Garrabou G, Flores-Costa R, Casulleras M, López-Vicario C, Zhang IW, Cantó-Santos J, Contreras BJ, Sánchez-Rodríguez MB, Romero-Grimaldo B, Horrillo R, Costa M, Arroyo V, Clària J (2023) Essential role for albumin in preserving liver cells from TNFα-induced mitochondrial injury. https://doi.org/10.1096/fj.202201526r	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Liver
Leduc-Gaudet 2023 Nat Commun	2023	Leduc-Gaudet JP, Franco-Romero A, Cefis M, Moamer A, Broering FE, Milan G, Sartori R, Chaffer TJ, Dulac M, Marcangeli V, Mayaki D, Huck L, Shams A, Morais JA, Duchesne E, Lochmuller H, Sandri M, Hussain SNA, Gouspillou G (2023) MYTHO is a novel regulator of skeletal muscle autophagy and integrity. https://doi.org/10.1038/s41467-023-36817-1	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Pacheco-Fuentes 2023 Oecologia	2023	Pacheco-Fuentes H, Ton R, Griffith SC (2023) Short- and long-term consequences of heat exposure on mitochondrial metabolism in zebra finches (Taeniopygia castanotis). https://doi.org/10.1007/s00442-023-05344-7	LEAK ROUTINE OXPHOS ET	N ROX	Intact cells	Birds	Blood cells
Vamesu 2023 JCI Insight	2023	Vamesu BM, Nicola T, Li R, Hazra S, Matalon S, Kaminski N, Ambalavanan N, Kandasamy J (2023) Thyroid hormone modulates hyperoxic neonatal lung injury and mitochondrial function. https://doi.org/10.1172/jci.insight.160697	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Lung;gill
Salmon 2023 Geroscience	2023	Salmón P, Millet C, Selman C, Monaghan P, Dawson NJ (2023) Tissue-specific reductions in mitochondrial efficiency and increased ROS release rates during ageing in zebra finches, Taeniopygia guttata. https://doi.org/10.1007/s11357-022-00624-1	LEAK OXPHOS	N CIV NS ROX	Homogenate	Birds	Skeletal muscle Liver
Calabria 2023 Biomedicines	2023	Calabria E, Muollo V, Cavedon V, Capovin T, Saccenti L, Passarotti F, Ghiotto L, Milanese C, Gelati M, Rudi D, Salvagno GL, Lippi G, Tam E, Schena F, Pogliaghi S (2023) Type 2 diabetes related mitochondrial defects in peripheral mononucleated blood cells from overweight postmenopausal women. https://doi.org/10.3390/biomedicines11010121	LEAK ROUTINE OXPHOS ET	N NS ROX S	Permeabilized cells Intact cells	Human	Blood cells
Ashok 2023 Mol Cell Biochem	2023	Ashok S, Raji SR, Manjunatha S, Srinivas G (2023) Impairment of substrate-mediated mitochondrial respiration in cardiac cells by chloroquine. https://doi.org/10.1007/s11010-023-04740-0	OXPHOS	F N S NS ROX	Isolated mitochondria	Mouse	Heart
Martell 2023 Nat Commun	2023	Martell E, Kuzmychova H, Kaul E, Senthil H, Chowdhury SR, Morrison LC, Fresnoza A, Zagozewski J, Venugopal C, Anderson CM, Singh SK, Banerji V, Werbowetski-Ogilvie TE, Sharif T (2023) Metabolism-based targeting of MYC via MPC-SOD2 axis-mediated oxidation promotes cellular differentiation in group 3 medulloblastoma. https://doi.org/10.1038/s41467-023-38049-9	LEAK ROUTINE OXPHOS ET	N S CIV ROX	Permeabilized cells Intact cells	Human	Nervous system
Wen 2023 PLoS One	2023	Wen W, Guo C, Chen Z, Yang D, Zhu D, Jing Q, Zheng L, Sun C, Tang C (2023) Regular exercise attenuates alcoholic myopathy in zebrafish by modulating mitochondrial homeostasis. https://doi.org/10.1371/journal.pone.0294700	LEAK ET OXPHOS	N S NS ROX	Intact cells	Zebrafish	Skeletal muscle
Garcia-Roche 2023 PLoS One	2023	García-Roche M, Talmón D, Cañibe G, Astessiano AL, Mendoza A, Cassina A, Quijano C, Carriquiry M (2023) Hepatic metabolism of grazing cows of two Holstein strains under two feeding strategies with different levels of pasture inclusion. https://doi.org/10.1371/journal.pone.0290551	LEAK OXPHOS ET	F N S NS ROX	Intact cells	Bovines	Liver
Zvejniece 2023 Biomed Pharmacother	2023	Zvejniece L, Svalbe B, Vavers E, Ozola M, Grinberga S, Gukalova B, Sevostjanovs E, Liepinsh E, Dambrova M (2023) Decreased long-chain acylcarnitine content increases mitochondrial coupling efficiency and prevents ischemia-induced brain damage in rats.	LEAK OXPHOS	N S CIV NS ROX	Isolated mitochondria	Rat
Ismaeel 2023 Physiol Rep	2023	Ismaeel A, Valentino TR, Burke B, Goh J, Saliu TP, Albathi F, Owen A, McCarthy JJ, Wen Y (2023) Acetate and succinate benefit host muscle energetics as exercise-associated post-biotics. https://doi.org/10.14814/phy2.15848	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Skeletal muscle
Silva Dias Vieira 2023 PLoS Negl Trop Dis	2023	Silva Dias Vieira C, Pinheiro Aguiar R, de Almeida Nogueira NP, Costa Dos Santos Junior G, Paes MC (2023) Glucose metabolism sustains heme-induced Trypanosoma cruzi epimastigote growth in vitro. https://doi.org/10.1371/journal.pntd.0011725	ROUTINE ET	ROX	Intact cells	Protists
Zhang 2023 Nat Commun	2023	Zhang Y, Fan Y, Hu H, Zhang X, Wang Z, Wu Z, Wang L, Yu X, Song X, Xiang P, Zhang X, Wang T, Tan S, Li C, Gao L, Liang X, Li S, Li N, Yue X, Ma C (2023) ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury. https://doi.org/10.1038/s41467-023-43439-0	LEAK OXPHOS ET	N S NS ROX	Intact cells	Mouse	Liver
Cortes 2023 Nat Commun	2023	Cortés M, Brischetto A, Martinez-Campanario MC, Ninfali C, Domínguez V, Fernández S, Celis R, Esteve-Codina A, Lozano JJ, Sidorova J, Garrabou G, Siegert AM, Enrich C, Pintado B, Morales-Ruiz M, Castro P, Cañete JD, Postigo A (2023) Inflammatory macrophages reprogram to immunosuppression by reducing mitochondrial translation. https://doi.org/10.1038/s41467-023-42277-4	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Batterson 2023 Physiol Rep	2023	Batterson PM, McGowan EM, Borowik AK, Kinter MT, Miller BF, Newsom SA, Robinson MM (2023) High-fat diet increases electron transfer flavoprotein synthesis and lipid respiration in skeletal muscle during exercise training in female mice. https://doi.org/10.14814/phy2.15840	LEAK OXPHOS ET	F N S Gp NS ROX	Isolated mitochondria	Mouse	Skeletal muscle
Sundaram 2023 Cell Metab	2023	Sundaram VK, Schütza V, Schröter NH, Backhaus A, Bilsing A, Joneck L, Seelbach A, Mutschler C, Gomez-Sanchez JA, Schäffner E, Sánchez EE, Akkermann D, Paul C, Schwagarus N, Müller S, Odle A, Childs G, Ewers D, Kungl T, Sitte M, Salinas G, Sereda MW, Nave KA, Schwab MH, Ost M, Arthur-Farraj P, Stassart RM, Fledrich R (2023) Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration. https://doi.org/10.1016/j.cmet.2023.10.017	LEAK OXPHOS ET	N S NS ROX	Intact cells	Mouse	Nervous system
Liu 2023 Pharmacol Res	2023	Liu S, Yue S, Guo Y, Han JY, Wang H (2023) Sorafenib induces cardiotoxicity through RBM20-mediated alternative splicing of sarcomeric and mitochondrial genes. https://doi.org/10.1016/j.phrs.2023.107017	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Rat	Heart
Dewidar 2023 EBioMedicine	2023	Dewidar B, Mastrototaro L, Englisch C, Ress C, Granata C, Rohbeck E, Pesta D, Heilmann G, Wolkersdorfer M, Esposito I, Reina Do Fundo M, Zivehe F, Yavas A, Roden M (2023) Alterations of hepatic energy metabolism in murine models of obesity, diabetes and fatty liver diseases. https://doi.org/10.1016/j.ebiom.2023.104714	LEAK OXPHOS ET	F N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle Liver
Noone 2023 J Physiol	2023	Noone J, Damiot A, Kenny H, Chery I, Zahariev A, Normand S, Crampes F, de Glisezinski I, Rochfort KD, Laurens C, Bareille MP, Simon C, Bergouignan A, Blanc S, O'Gorman DJ (2023) The impact of 60 days of -6° head down tilt bed rest on mitochondrial content, respiration and regulators of mitochondrial dynamics. https://doi.org/10.1113/jp284734	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Sharma 2023 Biosci Biotechnol Biochem	2023	Sharma S, Zhang X, Azhar G, Patyal P, Verma A, Kc G, Wei JY (2023) Valine improves mitochondrial function and protects against oxidative stress. https://doi.org/10.1093/bbb/zbad169	LEAK ROUTINE OXPHOS ET	N S CIV ROX	Permeabilized cells Intact cells	Mouse	Skeletal muscle
Janz 2023 Mol Metab	2023	Janz A, Walz K, Cirnu A, Surjanto J, Urlaub D, Leskien M, Kohlhaas M, Nickel A, Brand T, Nose N, Wörsdörfer P, Wagner N, Higuchi T, Maack C, Dudek J, Lorenz K, Klopocki E, Ergün S, Duff HJ, Gerull B (2023) Mutations in DNAJC19 cause altered mitochondrial structure and increased mitochondrial respiration in human iPSC-derived cardiomyocytes. https://doi.org/10.1016/j.molmet.2023.101859	LEAK ROUTINE ET	ROX	Intact cells	Human	HeLa
Yang 2023 Redox Biol	2023	Yang X, Gu C, Cai J, Li F, He X, Luo L, Xiao W, Hu B, Hu J, Qian H, Ren S, Zhang L, Zhu X, Yang L, Yang J, Yang Z, Zheng Y, Huang X, Wang Z (2023) Excessive SOX8 reprograms energy and iron metabolism to prime hepatocellular carcinoma for ferroptosis. https://doi.org/10.1016/j.redox.2023.103002	LEAK ET ROUTINE	ROX	Intact cells	Human	Liver
Chen 2023 Nat Commun	2023	Chen M, Zhu JY, Mu WJ, Luo HY, Li Y, Li S, Yan LJ, Li RY, Guo L (2023) Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice. https://doi.org/10.1038/s41467-023-44242-7	LEAK ROUTINE ET	ROX	Intact cells	Human	Liver
Dabrowska 2023 Int J Mol Sci	2023	Dabrowska A, Zajac M, Bednarczyk P, Lukasiak A (2023) Effect of quercetin on mitoBK_Ca channel and mitochondrial function in human bronchial epithelial cells exposed to particulate matter. Int J Mol Sci 24:638. https://doi.org/10.3390/ijms24010638	LEAK ROUTINE OXPHOS ET	S ROX	Permeabilized cells Intact cells	Human	Lung;gill Endothelial;epithelial;mesothelial cell
Bassot 2023 Cell Rep	2023	Bassot A, Chen J, Takahashi-Yamashiro K, Yap MC, Gibhardt CS, Le GNT, Hario S, Nasu Y, Moore J, Gutiérrez T, Mina L, Mast H, Moses A, Bhat R, Ballanyi K, Lemieux H, Sitia R, Zito E, Bogeski I, Campbell RE, Simmen T (2023) The endoplasmic reticulum kinase PERK interacts with the oxidoreductase ERO1 to metabolically adapt mitochondria. Cell Rep 42:111899. https://doi.org/10.1016/j.celrep.2022.111899	LEAK ROUTINE ET	ROX	Intact cells	Human Mouse	HEK Fibroblast
Verma 2023 Int J Mol Sci	2023	Verma A, Azhar G, Zhang X, Patyal P, Kc G, Sharma S, Che Y, Wei JY (2023) P. gingivalis-LPS induces mitochondrial dysfunction mediated by neuroinflammation through oxidative stress. Int J Mol Sci 24:950. https://doi.org/10.3390/ijms24020950	LEAK ROUTINE OXPHOS ET	N S CIV ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell
Glombik 2023 Int J Mol Sci	2023	Glombik K, Kukla-Bartoszek M, Curzytek K, Detka J, Basta-Kaim A, Budziszewska B (2023) The effects of prenatal dexamethasone exposure on brain metabolic homeostasis in adulthood: implications for depression. Int J Mol Sci 24:1156. https://doi.org/10.3390/ijms24021156	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Rat	Nervous system
Menail 2023 FASEB J	2023	Menail HA, Cormier SB, Léger A, Robichaud S, Hebert-Chatelain E, Lamarre SG, Pichaud N (2023) Age-related flexibility of energetic metabolism in the honey bee Apis mellifera. https://doi.org/10.1096/fj.202300654r	LEAK OXPHOS ET	N S Gp CIV NS ROX	Permeabilized tissue	Hexapods
Fisher-Wellman 2023 Cancers (Basel)	2023	Fisher-Wellman KH, Kassai M, Hagen JT, Neufer PD, Kester M, Loughran TP Jr, Chalfant CE, Feith DJ, Tan SF, Fox TE, Ung J, Fabrias G, Abad JL, Sharma A, Golla U, Claxton DF, Shaw JJP, Bhowmick D, Cabot MC (2023) Simultaneous inhibition of ceramide hydrolysis and glycosylation synergizes to corrupt mitochondrial respiration and signal caspase driven cell death in drug-resistant acute myeloid leukemia. https://doi.org/10.3390/cancers15061883	LEAK ROUTINE ET	F N NS ROX	Permeabilized cells Intact cells	Human	Blood cells
Steffen 2023 J Exp Biol	2023	Steffen JBM, Sokolov EP, Bock C, Sokolova IM (2023) Combined effects of salinity and intermittent hypoxia on mitochondrial capacity and reactive oxygen species efflux in the Pacific oyster, Crassostrea gigas. https://doi.org/10.1242/jeb.246164	LEAK OXPHOS ET	N CIV NS ROX	Isolated mitochondria	Molluscs	Lung;gill
Pharaoh 2023 Geroscience	2023	Pharaoh G, Kamat V, Kannan S, Stuppard RS, Whitson J, Martín-Pérez M, Qian WJ, MacCoss MJ, Villén J, Rabinovitch P, Campbell MD, Sweet IR, Marcinek DJ (2023) The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT). https://doi.org/10.1007/s11357-023-00861-y	LEAK OXPHOS	N S NS ROX	Permeabilized tissue Isolated mitochondria	Mouse	Skeletal muscle
Ebanks 2023 PLoS One	2023	Ebanks B, Kwiecinska P, Moisoi N, Chakrabarti L (2023) A method to assess the mitochondrial respiratory capacity of complexes I and II from frozen tissue using the Oroboros O2k-FluoRespirometer. https://doi.org/10.1371/journal.pone.0276147	ROUTINE LEAK	N S NS ROX	Homogenate	Mouse Drosophila	Skeletal muscle
Rodriguez 2023 BEC	2023	Rodríguez E, Bettinazzi S, Inwongwan S, Camus MF, Lane N (2023) Harmonizing protocols to measure Drosophila respiratory function in mitochondrial preparations. Bioenerg Commun 2023.3. https://doi.org/10.26124/bec:2023-0003	LEAK OXPHOS ET	N S Gp ROX	Permeabilized tissue Homogenate	Drosophila
Bowering 2023 Front Physiol	2023	Bowering LR, McArley TJ, Devaux JBL, Hickey AJR, Herbert NA (2023) Metabolic resilience of the Australasian snapper (Chrysophrys auratus) to marine heatwaves and hypoxia. https://doi.org/10.3389/fphys.2023.1215442	LEAK OXPHOS ET	N NS CIV ROX	Permeabilized tissue	Fishes	Heart
Sucha 2023 Int J Mol Sci	2023	Sucha M, Benediktova S, Tichanek F, Jedlicka J, Kapl S, Jelinkova D, Purkartova Z, Tuma J, Kuncova J, Cendelin J (2023) Experimental treatment with edaravone in a mouse model of spinocerebellar ataxia 1. https://doi.org/10.3390/ijms241310689		N S CIV NS ROX	Homogenate	Mouse	Nervous system
Thompson 2023 Geroscience	2023	Thompson SD, Barrett KL, Rugel CL, Redmond R, Rudofski A, Kurian J, Curtin JL, Dayanidhi S, Lavasani M (2023) Sex-specific preservation of neuromuscular function and metabolism following systemic transplantation of multipotent adult stem cells in a murine model of progeria. https://doi.org/10.1007/s11357-023-00892-5	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Awad-Igbaria 2023 J Transl Med	2023	Awad-Igbaria Y, Ferreira N, Keadan A, Sakas R, Edelman D, Shamir A, Francous-Soustiel J, Palzur E (2023) HBO treatment enhances motor function and modulates pain development after sciatic nerve injury via protection the mitochondrial function. https://doi.org/10.1186/s12967-023-04414-x	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Rat	Nervous system
Colosio 2023 J Appl Physiol (1985)	2023	Colosio M, Brocca L, Gatti M, Neri M, Crea E, Cadile F, Canepari M, Pellegrino MA, Polla B, Porcelli S, Bottinelli R (2023) Structural and functional impairments of skeletal muscle in patients with post-acute sequelae of SARS-CoV-2 infection. https://doi.org/10.1152/japplphysiol.00158.2023	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Mu 2023 STAR Protoc	2023	Mu C, Shearer J (2023) Protocol for measuring respiratory function of mitochondria in frozen colon tissue from rats. https://doi.org/10.1016/j.xpro.2023.102560	LEAK ET	N S NS ROX	Homogenate	Rat	Endothelial;epithelial;mesothelial cell
Noone 2023 Cell Signal	2023	Noone J, Rochfort KD, O'Sullivan F, O'Gorman DJ (2023) SIRT4 is a regulator of human skeletal muscle fatty acid metabolism influencing inner and outer mitochondrial membrane-mediated fusion. https://doi.org/10.1016/j.cellsig.2023.110931	LEAK OXPHOS	F N ROX	Permeabilized cells	Human	Skeletal muscle
Cherix 2022 Mol Psychiatry	2022	Cherix A, Poitry-Yamate C, Lanz B, Zanoletti O, Grosse J, Sandi C, Gruetter R, Cardinaux JR (2022) Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior. https://doi.org/10.1038/s41380-022-01791-5	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Gonzalez-Franquesa 2022 Redox Biol	2022	Gonzalez-Franquesa A, Gama-Perez P, Kulis M, Szczepanowska K, Dahdah N, Moreno-Gomez S, Latorre-Pellicer A, Fernández-Ruiz R, Aguilar-Mogas A, Hoffman A, Monelli E, Samino S, Miró-Blanch J, Oemer G, Duran X, Sanchez-Rebordelo E, Schneeberger M, Obach M, Montane J, Castellano G, Chapaprieta V, Sun W, Navarro L, Prieto I, Castaño C, Novials A, Gomis R, Monsalve M, Claret M, Graupera M, Soria G, Wolfrum C, Vendrell J, Fernández-Veledo S, Enríquez JA, Carracedo A, Perales JC, Nogueiras R, Herrero L, Trifunovic A, Keller MA, Yanes O, Sales-Pardo M, Guimerà R, Blüher M, Martín-Subero JI, Garcia-Roves PM (2022) Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. https://doi.org/10.1016/j.redox.2022.102353	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate	Mouse	Skeletal muscle Nervous system Liver Fat
Brown 2022 Redox Biol	2022	Brown JL, Peelor FF 3rd, Georgescu C, Wren JD, Kinter M, Tyrrell VJ, O'Donnell VB, Miller BF, Van Remmen H (2022) Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy. https://doi.org/10.1016/j.redox.2022.102518	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Meszaros 2022 EBioMedicine	2022	Meszaros AT, Hofmann J, Buch ML, Cardini B, Dunzendorfer-Matt T, Nardin F, Blumer MJ, Fodor M, Hermann M, Zelger B, Otarashvili G, Schartner M, Weissenbacher A, Oberhuber R, Resch T, Troppmair J, Öfner D, Zoller H, Tilg H, Gnaiger E, Hautz T, Schneeberger S (2022) Mitochondrial respiration during normothermic liver machine perfusion predicts clinical outcome. https://doi.org/10.1016/j.ebiom.2022.104311	OXPHOS ET LEAK	F N S NS ROX	Homogenate	Human	Liver
Zhang 2022 Int J Mol Sci	2022	Zhang A, Gupte AA, Chatterjee S, Li S, Ayala AG, Miles BJ, Hamilton DJ (2022) Enhanced succinate oxidation with mitochondrial complex II reactive oxygen species generation in human prostate cancer. https://doi.org/10.3390/ijms232012168	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Genital
Roy 2022 Am J Pathol	2022	Roy N, Alencastro F, Roseman BA, Wilson SR, Delgado ER, May MC, Bhushan B, Bello FM, Jurczak MJ, Shiva S, Locker J, Gingras S, Duncan AW (2022) Dysregulation of lipid and glucose homeostasis in hepatocyte-specific SLC25A34 knockout mice. https://doi.org/10.1016/j.ajpath.2022.06.002	LEAK OXPHOS ET	N NS ROX	Homogenate	Mouse	Liver
Xu 2022 Sci Adv	2022	Xu H, Ahn B, Van Remmen H (2022) Impact of aging and oxidative stress on specific components of excitation contraction coupling in regulating force generation. https://doi.org/10.1126/sciadv.add7377	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Nadeu 2022 Nat Med	2022	Nadeu F, Royo R, Massoni-Badosa R, Playa-Albinyana H, Garcia-Torre B, Duran-Ferrer M, Dawson KJ, Kulis M, Diaz-Navarro A, Villamor N, Melero JL, Chapaprieta V, Dueso-Barroso A, Delgado J, Moia R, Ruiz-Gil S, Marchese D, Giró A, Verdaguer-Dot N, Romo M, Clot G, Rozman M, Frigola G, Rivas-Delgado A, Baumann T, Alcoceba M, González M, Climent F, Abrisqueta P, Castellví J, Bosch F, Aymerich M, Enjuanes A, Ruiz-Gaspà S, López-Guillermo A, Jares P, Beà S, Capella-Gutierrez S, Gelpí JL, López-Bigas N, Torrents D, Campbell PJ, Gut I, Rossi D, Gaidano G, Puente XS, Garcia-Roves PM, Colomer D, Heyn H, Maura F, Martín-Subero JI, Campo E (2022) Detection of early seeding of Richter transformation in chronic lymphocytic leukemia. https://doi.org/10.1038/s41591-022-01927-8	LEAK ROUTINE ET	ROX	Intact cells	Human	Lymphocyte Blood cells
Li 2022 Mol Med	2022	Li X, Zhou X, Liu X, Li X, Jiang X, Shi B, Wang S (2022) Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway. https://doi.org/10.1186/s10020-022-00533-1	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Human	Blood cells
Sarabhai 2022 Diabetologia	2022	Sarabhai T, Mastrototaro L, Kahl S, Bönhof GJ, Jonuscheit M, Bobrov P, Katsuyama H, Guthoff R, Wolkersdorfer M, Herder C, Meuth SG, Dreyer S, Roden M (2022) Hyperbaric oxygen rapidly improves tissue-specific insulin sensitivity and mitochondrial capacity in humans with type 2 diabetes: a randomised placebo-controlled crossover trial. https://doi.org/10.1007/s00125-022-05797-0	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Human	Skeletal muscle Fat
Mandic 2022 J Comp Physiol B	2022	Mandic M, Frazier AJ, Naslund AW, Todgham AE (2022) A comparative and ontogenetic examination of mitochondrial function in antarctic notothenioid species. https://doi.org/10.1007/s00360-022-01461-6	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Fishes	Heart
Zhang 2022 Ecotoxicol Environ Saf	2022	Zhang Y, Yuan F, Li P, Gu J, Han J, Ni Z, Liu F (2022) Resveratrol inhibits HeLa cell proliferation by regulating mitochondrial function. https://doi.org/10.1016/j.ecoenv.2022.113788	LEAK ROUTINE ET	ROX	Intact cells	Human	HeLa
Liu 2022 Adv Sci (Weinh)	2022	Liu H, Liu Y, Wang H, Zhao Q, Zhang T, Xie SA, Liu Y, Tang Y, Peng Q, Pang W, Yao W, Zhou J (2022) Geometric constraints regulate energy metabolism and cellular contractility in vascular smooth muscle cells by coordinating mitochondrial DNA methylation. https://doi.org/10.1002/advs.202203995	LEAK OXPHOS	N S CIV ROX	Permeabilized cells	Human	Other cell lines
Cano-Sanchez 2022 PLoS Negl Trop Dis	2022	Cano-Sanchez M, Ben-Hassen K, Louis OP, Dantin F, Gueye P, Roques F, Mehdaoui H, Resiere D, Neviere R (2022) Bothrops lanceolatus snake venom impairs mitochondrial respiration and induces DNA release in human heart preparation. https://doi.org/10.1371/journal.pntd.0010523	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Human	Heart
Paulus 2022 Basic Res Cardiol	2022	Paulus MG, Renner K, Nickel AG, Brochhausen C, Limm K, Zügner E, Baier MJ, Pabel S, Wallner S, Birner C, Luchner A, Magnes C, Oefner PJ, Stark KJ, Wagner S, Maack C, Maier LS, Streckfuss-Bömeke K, Sossalla S, Dietl A (2022) Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions. https://doi.org/10.1007/s00395-022-00949-0	OXPHOS ET	NS F ROX	Permeabilized tissue Isolated mitochondria	Rabbit	Heart
Zhu 2022 Metabolism	2022	Zhu JY, Chen M, Mu WJ, Luo HY, Guo L (2022) Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice. https://doi.org/10.1016/j.metabol.2022.155241	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Liver
Zhang 2022 Nat Metab	2022	Zhang CS, Li M, Wang Y, Li X, Zong Y, Long S, Zhang M, Feng JW, Wei X, Liu YH, Zhang B, Wu J, Zhang C, Lian W, Ma T, Tian X, Qu Q, Yu Y, Xiong J, Liu DT, Wu Z, Zhu M, Xie C, Wu Y, Xu Z, Yang C, Chen J, Huang G, He Q, Huang X, Zhang L, Sun X, Liu Q, Ghafoor A, Gui F, Zheng K, Wang W, Wang ZC, Yu Y, Zhao Q, Lin SY, Wang ZX, Piao HL, Deng X, Lin SC (2022) The aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK. https://doi.org/10.1038/s42255-022-00640-7	LEAK OXPHOS	N S CIV ROX	Permeabilized tissue	Mouse	Skeletal muscle
Risiglione 2022 Life (Basel)	2022	Risiglione P, Cubisino SAM, Lipari CLR, De Pinto V, Messina A, Magrì A (2022) α-Synuclein A53T promotes mitochondrial proton gradient dissipation and depletion of the organelle respiratory reserve in a neuroblastoma cell line. https://doi.org/10.3390/life12060894	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Neuroblastoma
De Paula Nascimento-Castro 2022 Biomedicines	2022	de Paula Nascimento-Castro C, Winkelmann-Duarte EC, Mancini G, Welter PG, Plácido E, Farina M, Gil-Mohapel J, Rodrigues ALS, de Bem AF, Brocardo PS (2022) Temporal characterization of behavioral and hippocampal dysfunction in the YAC128 mouse model of Huntington's disease. https://doi.org/10.3390/biomedicines10061433	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Saraiva 2022 Pathogens	2022	Saraiva FMS, Cosentino-Gomes D, Inacio JDF, Almeida-Amaral EE, Louzada-Neto O, Rossini A, Nogueira NP, Meyer-Fernandes JR, Paes MC (2022) Hypoxia effects on Trypanosoma cruzi epimastigotes proliferation, differentiation, and energy metabolism. https://doi.org/10.3390/pathogens11080897	LEAK OXPHOS	S ROX	Permeabilized cells	Protists
Fuertes-Agudo 2022 Antioxidants (Basel)	2022	Fuertes-Agudo M, Luque-Tévar M, Cucarella C, Brea R, Boscá L, Quintana-Cabrera R, Martín-Sanz P, Casado M (2022) COX-2 expression in hepatocytes improves mitochondrial function after hepatic ischemia-reperfusion injury.	OXPHOS ET	F N Gp CIV NS Other combinations ROX	Isolated mitochondria	Mouse	Liver
Wang 2022 Redox Biol	2022	Wang P, Cui Y, Liu Y, Li Z, Bai H, Zhao Y, Chang YZ (2022) Mitochondrial ferritin alleviates apoptosis by enhancing mitochondrial bioenergetics and stimulating glucose metabolism in cerebral ischemia reperfusion. https://doi.org/10.1016/j.redox.2022.102475	LEAK OXPHOS ET	N ROX	Homogenate	Mouse	Nervous system
Quemeneur 2022 Sci Rep	2022	Quéméneur JB, Danion M, Cabon J, Collet S, Zambonino-Infante JL, Salin K (2022) The relationships between growth rate and mitochondrial metabolism varies over time. https://doi.org/10.1038/s41598-022-20428-9	LEAK OXPHOS	N CIV NS ROX	Homogenate	Fishes	Skeletal muscle
Fernandez-Vizarra 2022 Cell Metab	2022	Fernández-Vizarra E, López-Calcerrada S, Sierra-Magro A, Pérez-Pérez R, Formosa LE, Hock DH, Illescas M, Peñas A, Brischigliaro M, Ding S, Fearnley IM, Tzoulis C, Pitceathly RDS, Arenas J, Martín MA, Stroud DA, Zeviani M, Ryan MT, Ugalde C (2022) Two independent respiratory chains adapt OXPHOS performance to glycolytic switch. https://doi.org/10.1016/j.cmet.2022.09.005	LEAK ET	N S Gp NS ROX	Permeabilized cells Intact cells	Human	HEK
Neupane 2022 Commun Biol	2022	Neupane N, Rajendran J, Kvist J, Harjuhaahto S, Hu B, Kinnunen V, Yang Y, Nieminen AI, Tyynismaa H (2022) Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle. https://doi.org/10.1038/s42003-022-04034-z	OXPHOS ET	N NS ROX	Isolated mitochondria	Mouse	Skeletal muscle
Felix 2022 Chemosphere	2022	Félix L, Carreira P, Peixoto F (2022) Effects of chronic exposure of naturally weathered microplastics on oxidative stress level, behaviour, and mitochondrial function of adult zebrafish (Danio rerio). https://doi.org/10.1016/j.chemosphere.2022.136895	LEAK OXPHOS	N S CIV ROX	Homogenate	Zebrafish	Nervous system Liver
Ceja-Galicia 2022 Antioxidants (Basel)	2022	Ceja-Galicia ZA, García-Arroyo FE, Aparicio-Trejo OE, El-Hafidi M, Gonzaga-Sánchez G, León-Contreras JC, Hernández-Pando R, Guevara-Cruz M, Tovar AR, Rojas-Morales P, Aranda-Rivera AK, Sánchez-Lozada LG, Tapia E, Pedraza-Chaverri J (2022) Therapeutic effect of curcumin on 5/6Nx hypertriglyceridemia: association with the improvement of renal mitochondrial β-oxidation and lipid metabolism in kidney and liver. https://doi.org/10.3390/antiox11112195	LEAK OXPHOS	F N ROX	Isolated mitochondria	Rat	Kidney
Gutierrez 2022 Cell Rep Med	2022	Gutierrez AD, Gao Z, Hamidi V, Zhu L, Saint Andre KB, Riggs K, Ruscheinsky M, Wang H, Yu Y, Miller C 3rd, Vasquez H, Taegtmeyer H, Kolonin MG (2022) Anti-diabetic effects of GLP1 analogs are mediated by thermogenic interleukin-6 signaling in adipocytes. https://doi.org/10.1016/j.xcrm.2022.100813	LEAK	S ROX		Mouse	Fat
Tilokani 2022 Sci Adv	2022	Tilokani L, Russell FM, Hamilton S, Virga DM, Segawa M, Paupe V, Gruszczyk AV, Protasoni M, Tabara LC, Johnson M, Anand H, Murphy MP, Hardie DG, Polleux F, Prudent J (2022) AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology. https://doi.org/10.1126/sciadv.abo7956	LEAK ROUTINE ET	ROX	Intact cells	Human	Other cell lines
Karavyraki 2022 BEC	2022	Karavyraki M, Gnaiger E, Porter RK (2022) Bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. Bioenerg Commun 2022.11. https://doi.org/10.26124/bec:2022-0011	LEAK ROUTINE ET	S ROX	Permeabilized cells	Human
Dieter 2022 Int J Mol Sci	2022	Dieter F, Esselun C, Eckert GP (2022) Redox active α-lipoic acid differentially improves mitochondrial dysfunction in a cellular model of Alzheimer and its control cells. https://doi.org/10.3390/ijms23169186	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Neuroblastoma
Babylon 2022 Int J Mol Sci	2022	Babylon L, Schmitt F, Franke Y, Hubert T, Eckert GP (2022) Effects of combining biofactors on bioenergetic parameters, Aβ levels and survival in Alzheimer model organisms. https://doi.org/10.3390/ijms23158670	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Neuroblastoma
Vizuete 2022 J Neuroinflammation	2022	Vizuete AFK, Fróes F, Seady M, Zanotto C, Bobermin LD, Roginski AC, Wajner M, Quincozes-Santos A, Gonçalves CA (2022) Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway. https://doi.org/10.1186/s12974-022-02612-w	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Crowder 2022 Islets	2022	Crowder JJ, Zeng Z, Novak AN, Alves NJ, Linnemann AK (2022) Stabilization protects islet integrity during respirometry in the Oroboros Oxygraph-2K analyzer. Islets 14:128-38.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Islet cell;pancreas;thymus
Deng 2022 Cell Mol Life Sci	2022	Deng H, Gao Y, Trappetti V, Hertig D, Karatkevich D, Losmanova T, Urzi C, Ge H, Geest GA, Bruggmann R, Djonov V, Nuoffer JM, Vermathen P, Zamboni N, Riether C, Ochsenbein A, Peng RW, Kocher GJ, Schmid RA, Dorn P, Marti TM (2022) Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage. https://doi.org/10.1007/s00018-022-04453-5	LEAK	ROX N S CIV	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell
Guo 2022 Sci Adv	2022	Guo Q, Xu Z, Zhou D, Fu T, Wang W, Sun W, Xiao L, Liu L, Ding C, Yin Y, Zhou Z, Sun Z, Zhu Y, Zhou W, Jia Y, Xue J, Chen Y, Chen XW, Piao HL, Lu B, Gan Z (2022) Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4. https://doi.org/10.1126/sciadv.abo0340	LEAK OXPHOS	N S ROX	Permeabilized tissue Isolated mitochondria	Mouse	Skeletal muscle Fat
Tepp 2022 Biochem Biophys Rep	2022	Tepp K, Aid-Vanakova J, Puurand M, Timohhina N, Reinsalu L, Tein K, Plaas M, Shevchuk I, Terasmaa A, Kaambre T (2022) Wolframin deficiency is accompanied with metabolic inflexibility in rat striated muscles. Biochem Biophys Rep 30:101250.	LEAK OXPHOS	N S CIV ROX	Permeabilized tissue	Rat	Skeletal muscle
Serna 2022 BEC	2022	Serna JDC, Ramos VM, Cabral-Costa JV, Vilas-Boas EA, Amaral AG, Ohya G, da Silva CCC, Kowaltowski AJ (2022) Measuring mitochondrial Ca²⁺ efflux in isolated mitochondria and permeabilized cells. Bioenerg Commun 2022.7. https://doi.org/10.26124/bec:2022-0007	LEAK OXPHOS	S ROX	Permeabilized cells Isolated mitochondria	Human Mouse	Liver Other cell lines
Zdrazilova 2022 PLOS ONE	2022	Zdrazilova L, Hansikova H, Gnaiger E (2022) Comparable respiratory activity in attached and suspended human fibroblasts. PLoS ONE 17:e0264496. https://doi.org/10.1371/journal.pone.0264496	LEAK ROUTINE ET	ROX	Intact cells	Human	Fibroblast
Molinie 2022 Biochim Biophys Acta Bioenerg	2022	Molinié T, Cougouilles E, David C, Cahoreau E, Portais JC, Mourier A (2022) MDH2 produced OAA is a metabolic switch rewiring the fuelling of respiratory chain and TCA cycle. Biochim Biophys Acta Bioenerg 1863:148532.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Heart Liver
Goudie 2022 Sci Rep	2022	Goudie L, Mancini NL, Shutt TE, Holloway GP, Mu C, Wang A, McKay DM, Shearer J (2022) Impact of experimental colitis on mitochondrial bioenergetics in intestinal epithelial cells. https://doi.org/10.1038/s41598-022-11123-w	LEAK OXPHOS ET	N S CIV ROX	Permeabilized cells	Mouse	Endothelial;epithelial;mesothelial cell
Nath 2022 Cell Rep	2022	Nath AS, Parsons BD, Makdissi S, Chilvers RL, Mu Y, Weaver CM, Euodia I, Fitze KA, Long J, Scur M, Mackenzie DP, Makrigiannis AP, Pichaud N, Boudreau LH, Simmonds AJ, Webber CA, Derfalvi B, Hammon Y, Rachubinski RA, Di Cara F (2022) Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses . Cell Rep 38:110433.	LEAK ROUTINE OXPHOS ET	N Gp CIV ROX	Permeabilized cells Intact cells
Thapa 2022 Physiol Rep	2022	Thapa D, Bugga P, Mushala BAS, Manning JR, Stoner MW, McMahon B, Zeng X, Cantrell PS, Yates N, Xie B, Edmunds LR, Jurczak MJ, Scott I (2022) GCN5L1 impairs diastolic function in mice exposed to a high fat diet by restricting cardiac pyruvate oxidation. https://doi.org/10.14814/phy2.15415	LEAK OXPHOS ET	N ROX		Mouse	Heart
Heimler 2022 BEC	2022	Heimler SR, Phang HJ, Bergstrom J, Mahapatra G, Dozier S, Gnaiger E, Molina AJA (2022) Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older adult women. Bioenerg Commun 2022.2. https://doi.org/10.26124/bec:2022-0002	OXPHOS ET	F N S Gp ROX	Permeabilized cells	Human	Blood cells
Karavyraki 2022 MitoFit	2022	Karavyraki M, Gnaiger E, Porter RK (2022) A comparison of bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. https://doi.org/10.26124/mitofit:2022-0022 — 2022-11-11 published in Bioenerg Commun 2022.11.	LEAK ROUTINE ET	S ROX	Permeabilized cells	Human
Pallag 2022 Int J Mol Sci	2022	Pallag G, Nazarian S, Ravasz D, Bui D, Komlódi T, Doerrier C, Gnaiger E, Seyfried TN, Chinopoulos C (2022) Proline oxidation supports mitochondrial ATP production when Complex I is inhibited. https://doi.org/10.3390/ijms23095111	LEAK OXPHOS ET	N S Gp CIV NS Other combinations ROX	Isolated mitochondria	Mouse	Liver Kidney
Serna 2022 MitoFit	2022	Serna JDC, Ramos VM, Cabral-Costa JV, Vilas-Boas EA, Amaral AG, Ohya G, da Silva CCC, Kowaltowski AJ (2022) Measuring mitochondrial Ca²⁺ efflux in isolated mitochondria and permeabilized cells. https://doi.org/10.26124/mitofit:2022-0021 — 2022-07-28 published in Bioenerg Commun 2022.7.	LEAK OXPHOS	S ROX	Permeabilized cells Isolated mitochondria	Human Mouse	Liver Other cell lines
Torres-Quesada 2022 MitoFit	2022	Torres-Quesada O, Doerrier C, Strich S, Gnaiger E, Stefan E (2022) Human Plasma-Like Media fine-tune mitochondrial function and alter drug sensitivity in cancer cell lines. https://doi.org/10.26124/mitofit:2022-0008 — 2022-08-13 published in https://doi.org/10.3390/cancers14163917	ROUTINE LEAK ET	ROX	Intact cells	Human	Other cell lines
Ahn 2022 Aging Cell	2022	Ahn B, Ranjit R, Kneis P, Xu H, Piekarz KM, Freeman WM, Kinter M, Richardson A, Ran Q, Brooks SV, Van Remmen H (2022) Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia. Aging Cell 21:e13569.	LEAK OXPHOS	N S NS ROX	Isolated mitochondria	Mouse	Skeletal muscle
Fischer 2022 Metabolites	2022	Fischer C, Valente de Souza L, Komlódi T, Garcia-Souza LF, Volani C, Tymoszuk P, Demetz E, Seifert M, Auer K, Hilbe R, Brigo N, Petzer V, Asshoff M, Gnaiger E, Weiss G (2022) Mitochondrial respiration in response to iron deficiency anemia. Comparison of peripheral blood mononuclear cells and liver. https://doi.org/10.3390/metabo12030270	LEAK ROUTINE OXPHOS ET	N S NS Other combinations ROX	Permeabilized cells Homogenate	Rat	Liver Blood cells
Hong 2022 Cell Stem Cell	2022	Hong X, Isern J, Campanario S, Perdiguero E, Ramírez-Pardo I, Segalés J, Hernansanz-Agustín P, Curtabbi A, Deryagin O, Pollán A, González-Reyes JA, Villalba JM, Sandri M, Serrano AL, Enríquez JA, Muñoz-Cánoves P (2022) Mitochondrial dynamics maintain muscle stem cell regenerative competence throughout adult life by regulating metabolism and mitophagy. https://doi.org/10.1016/j.stem.2022.07.009	LEAK OXPHOS	N S CIV NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Meza-Buendia 2022 PLoS One	2022	Meza-Buendia AK, Aparicio-Trejo OE, Díaz F, Caamal-Monsreal C, Pedraza-Chaverri J, Álvarez-Delgado C, Paschke K, Rosas C (2022) High resolution respirometry of isolated mitochondria from adult Octopus maya (Class: Cephalopoda) systemic heart. https://doi.org/10.1371/journal.pone.0273554	LEAK OXPHOS	ROX	Isolated mitochondria	Molluscs	Heart
Wu 2022 Antioxidants (Basel)	2022	Wu YL, Chang JC, Chao YC, Chan H, Hsieh M, Liu CS (2022) In vitro efficacy and molecular mechanism of curcumin analog in pathological regulation of spinocerebellar ataxia type 3. https://doi.org/10.3390/antiox11071389	LEAK OXPHOS ET	N S NS ROX	Intact cells	Human	Neuroblastoma
Trewin 2022 BMC Biol	2022	Trewin AJ, Silver J, Dillon HT, Della Gatta PA, Parker L, Hiam DS, Lee YP, Richardson M, Wadley GD, Lamon S (2022) Long non-coding RNA Tug1 modulates mitochondrial and myogenic responses to exercise in skeletal muscle. https://doi.org/10.1186/s12915-022-01366-4	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Laehteenmaeki 2022 Physiol Rep	2022	Lähteenmäki EI, Koski M, Koskela I, Lehtonen E, Kankaanpää A, Kainulainen H, Walker S, Lehti M (2022) Resistance exercise with different workloads have distinct effects on cellular respiration of peripheral blood mononuclear cells. https://doi.org/10.14814/phy2.15394	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Long 2022 Cell Commun Signal	2022	Long C, Guo R, Han R, Li K, Wan Y, Xu J, Gong X, Zhao Y, Yao X, Liu J (2022) Effects of macrophages on the proliferation and cardiac differentiation of human induced pluripotent stem cells. https://doi.org/10.1186/s12964-022-00916-1	LEAK ROUTINE ET	ROX	Intact cells	Human	Macrophage-derived
Smith 2022 J Pineal Res	2022	Smith KLM, Swiderska A, Lock MC, Graham L, Iswari W, Choudhary T, Thomas D, Kowash HM, Desforges M, Cottrell EC, Trafford AW, Giussani DA, Galli GLJ (2022) Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex-dependent manner. https://doi.org/10.1111/jpi.12821	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Rat	Heart
Torres-Quesada 2022 Cancers (Basel)	2022	Torres-Quesada O, Doerrier C, Strich S, Gnaiger E, Stefan E (2022) Physiological cell culture media tune mitochondrial bioenergetics and drug sensitivity in cancer cell models. https://doi.org/10.3390/cancers14163917	LEAK ROUTINE ET	ROX	Intact cells	Human	Other cell lines
Leggio 2022 Adv Healthc Mater	2022	Leggio L, L'Episcopo F, Magrì A, Ulloa-Navas MJ, Paternò G, Vivarelli S, Bastos CAP, Tirolo C, Testa N, Caniglia S, Risiglione P, Pappalardo F, Serra A, García-Tárraga P, Faria N, Powell JJ, Peruzzotti-Jametti L, Pluchino S, García-Verdugo JM, Messina A, Marchetti B, Iraci N (2022) Small extracellular vesicles secreted by nigrostriatal astrocytes rescue cell death and preserve mitochondrial function in Parkinson's disease. https://doi.org/10.1002/adhm.202201203	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Neuroblastoma
O'Hanlon 2022 Neurobiol Dis	2022	O'Hanlon ME, Tweedy C, Scialo F, Bass R, Sanz A, Smulders-Srinivasan TK (2022) Mitochondrial electron transport chain defects modify Parkinson's disease phenotypes in a Drosophila model. https://doi.org/10.1016/j.nbd.2022.105803	LEAK OXPHOS	N Gp CIV ROX	Homogenate	Drosophila
Hadjihambi 2022 J Hepatol	2022	Hadjihambi A, Konstantinou C, Klohs J, Monsorno K, Le Guennec A, Donnelly C, Cox J, Kusumbe A, Hosford PS, Soffientini U, Lecca S, Mameli M, Jalan R, Paolicelli RC, Pellerin L (2022) Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction. https://doi.org/10.1016/j.jhep.2022.08.008	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate	Mouse	Nervous system
Jelenik 2022 Pharmacol Res	2022	Jelenik T, Kodde A, Pesta D, Phielix E, Oosting A, Rohbeck E, Dewidar B, Mastrototaro L, Trenkamp S, Keijer J, van der Beek EM, Roden M (2022) Dietary lipid droplet structure in postnatal life improves hepatic energy and lipid metabolism in a mouse model for postnatal programming. https://doi.org/10.1016/j.phrs.2022.106193	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle Liver
Schober 2022 Hum Mol Genet	2022	Schober FA, Tang JX, Sergeant K, Moedas MF, Zierz CM, Moore D, Smith C, Lewis D, Guha N, Hopton S, Falkous G, Lam A, Pyle A, Poulton J, Gorman GS, Taylor RW, Freyer C, Wredenberg A (2022) Pathogenic SLC25A26 variants impair SAH transport activity causing mitochondrial disease. https://doi.org/10.1093/hmg/ddac002	LEAK OXPHOS	N S CIV NS ROX	Permeabilized cells Intact cells	Mouse Drosophila	Fibroblast
Ilha 2022 Cell Biol Int	2022	Ilha M, Meira Martins LA, da Silveira Moraes K, Dias CK, Thomé MP, Petry F, Rohden F, Borojevic R, Trindade VMT, Klamt F, Barbé-Tuana F, Lenz G, Guma FCR (2022) Caveolin-1 influences mitochondrial plasticity and function in hepatic stellate cell activation. https://doi.org/10.1002/cbin.11876	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Liver
De Goede 2022 FASEB J	2022	de Goede P, Wüst RCI, Schomakers BV, Denis S, Vaz FM, Pras-Raves ML, van Weeghel M, Yi CX, Kalsbeek A, Houtkooper RH (2022) Time-restricted feeding during the inactive phase abolishes the daily rhythm in mitochondrial respiration in rat skeletal muscle. FASEB J 36:e22133.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Rat	Skeletal muscle
Pileggi 2022 EBioMedicine	2022	Pileggi CA, Blondin DP, Hooks BG, Parmar G, Alecu I, Patten DA, Cuillerier A, O'Dwyer C, Thrush AB, Fullerton MD, Bennett SAL, Doucet É, Haman F, Cuperlovic-Culf M, McPherson R, Dent RRM, Harper ME (2022) Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity. https://doi.org/10.1016/j.ebiom.2022.104192	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Human	Skeletal muscle
Adant 2022 Mol Metab	2022	Adant I, Bird M, Decru B, Windmolders P, Wallays M, de Witte P, Rymen D, Witters P, Vermeersch P, Cassiman D, Ghesquière B (2022) Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction. https://doi.org/10.1016/j.molmet.2022.101537	LEAK OXPHOS ET	N S Gp CIV NS ROX	Permeabilized cells	Human	Fibroblast
Galambo 2022 Curr Res Physiol	2022	Galambo D, Bergdahl A (2022) Physiological levels of cardiolipin acutely affect mitochondrial respiration in vascular smooth muscle cells. https://doi.org/10.1016/j.crphys.2022.100097	LEAK OXPHOS	F N NS ROX	Permeabilized cells	Mouse	Other cell lines
Hadanny 2022 Sports Med Open	2022	Hadanny A, Hachmo Y, Rozali D, Catalogna M, Yaakobi E, Sova M, Gattegno H, Abu Hamed R, Lang E, Polak N, Friedman M, Finci S, Zemel Y, Bechor Y, Gal N, Efrati S (2022) Effects of hyperbaric oxygen therapy on mitochondrial respiration and physical performance in middle-aged athletes: a blinded, randomized controlled trial.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Crislip 2022 Biomolecules	2022	Crislip GR, Wohlgemuth SE, Wolff CA, Gutierrez-Monreal MA, Douglas CM, Ebrahimi E, Cheng KY, Masten SH, Barral D, Bryant AJ, Esser KA, Gumz ML (2022) Apparent absence of BMAL1-dependent skeletal muscle-kidney cross talk in mice. https://doi.org/10.3390/biom12020261	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Kidney
Napso 2022 Acta Physiol (Oxf)	2022	Napso T, Lean SC, Lu M, Mort EJ, Desforges M, Moghimi A, Bartels B, El-Bacha T, Fowden AL, Camm EJ, Sferruzzi-Perri AN (2022) Diet-induced maternal obesity impacts feto-placental growth and induces sex-specific alterations in placental morphology, mitochondrial bioenergetics, dynamics, lipid metabolism and oxidative stress in mice. https://doi.org/10.1111/apha.13795	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Mouse	Genital
Olesen 2022 Metabol Open	2022	Olesen K, Moruzzi N, Bulatovic I, Folmes C, Jeon R, Felldin U, Terzic A, Simonson OE, Le Blanc K, Österholm C, Berggren PO, Schiffer T, Rodin S, Tilevik A, Grinnemo KH (2022) Diversity of respiratory parameters and metabolic adaptation to low oxygen tension in mesenchymal stromal cells. https://doi.org/10.1016/j.metop.2022.100167	LEAK OXPHOS	N S NS ROX	Permeabilized cells	Human	Other cell lines
Rome 2022 Mol Metab	2022	Rome FI, Hughey CC (2022) Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction. https://doi.org/10.1016/j.molmet.2022.101452	LEAK OXPHOS ET	N CIV ROX	Isolated mitochondria	Mouse	Liver
Pinho 2022 Antioxidants (Basel)	2022	Pinho N, Bombaça AC, Wiśniewski JR, Dias-Lopes G, Saboia-Vahia L, Cupolillo E, de Jesus JB, de Almeida RP, Padrón G, Menna-Barreto R, Cuervo P (2022) Nitric oxide resistance in Leishmania (Viannia) braziliensis involves regulation of glucose consumption, glutathione metabolism and abundance of pentose phosphate pathway enzymes. https://doi.org/10.3390/antiox11020277		ROX	Intact organism	Protists
Lopes 2022 Int J Mol Sci	2022	Lopes JA, Collino F, Rodrigues-Ferreira C, Sampaio LDS, Costa-Sarmento G, Wendt CHC, Almeida FP, Miranda KR, Kasai-Brunswick TH, Lindoso RS, Vieyra A (2022) Early effects of extracellular vesicles secreted by adipose tissue mesenchymal cells in renal ischemia followed by reperfusion: mechanisms rely on a decrease in mitochondrial anion superoxide production. https://doi.org/10.3390/ijms23062906	LEAK OXPHOS ET	S ROX	Isolated mitochondria	Human	Kidney
Damgaard 2022 iScience	2022	Damgaard MV, Nielsen TS, Basse AL, Chubanava S, Trost K, Moritz T, Dellinger RW, Larsen S, Treebak JT (2022) Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD⁺ without impacting respiratory capacity or insulin sensitivity. iScience 25:103863. https://doi.org/10.1016/j.isci.2022.103863	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Antona 2022 Cancers (Basel)	2022	Antona A, Varalda M, Roy K, Favero F, Mazzucco E, Zuccalà M, Leo G, Soggia G, Bettio V, Tosi M, Gaggianesi M, Riva B, Reano S, Genazzani A, Manfredi M, Stassi G, Corà D, D'Alfonso S, Capello D (2022) Dissecting the mechanism of action of spiperone-a candidate for drug repurposing for colorectal cancer. https://doi.org/10.3390/cancers14030776	LEAK OXPHOS ET	N ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Chojnacka 2022 Mol Biol Cell	2022	Chojnacka KJ, Elancheliyan P, Mussulini BHM, Mohanraj K, Callegari S, Gosk A, Banach T, Góral T, Szczepanowska K, Rehling P, Serwa RA, Chacinska A (2022) Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) is a novel complex III-specific assembly factor in mitochondria. https://doi.org/10.1091/mbc.e21-03-0143	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Permeabilized cells Intact cells	Human	HEK
De Jong 2022 Nutrients	2022	De Jong NP, Rudolph MC, Jackman MR, Sharp RR, Jones K, Houck J, Pan Z, Reusch JEB, MacLean PS, Bessesen DH, Bergouignan A (2022) Short-term adaptations in skeletal muscle mitochondrial oxidative capacity and metabolic pathways to breaking up sedentary behaviors in overweight or obese adults. https://doi.org/10.3390/nu14030454	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Hansen 2022 Free Radic Biol Med	2022	Hansen C, Møller S, Ehlers T, Wickham KA, Bangsbo J, Gliemann L, Hellsten Y (2022) Redox balance in human skeletal muscle-derived endothelial cells - Effect of exercise training. https://doi.org/10.1016/j.freeradbiomed.2021.12.265	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell
Englund 2022 Mol Metab	2022	Englund DA, Jolliffe A, Aversa Z, Zhang X, Sturmlechner I, Sakamoto AE, Zeidler JD, Warner GM, McNinch C, White TA, Chini EN, Baker DJ, van Deursen JM, LeBrasseur NK (2022) p21 induces a senescence program and skeletal muscle dysfunction. https://doi.org/10.1016/j.molmet.2022.101652	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Pochakom 2022 Brain Sci	2022	Pochakom A, Mu C, Rho JM, Tompkins TA, Mayengbam S, Shearer J (2022) Selective probiotic treatment positively modulates the microbiota-gut-brain axis in the BTBR mouse model of autism. https://doi.org/10.3390/brainsci12060781	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Nervous system
Lu 2022 J Cosmet Dermatol	2022	Lu Q, Zou LF, Gao YZ, Ye T, Li MJ, Zhang YK, Liang B, Sun W, Xing DM (2022) Liquiritigenin reverses skin aging by inhibiting UV-induced mitochondrial uncoupling and excessive energy consumption. https://doi.org/10.1111/jocd.15506	LEAK ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell
Jedlicka 2022 Physiol Res	2022	Jedlička J, Grundmanová M, Švíglerová J, Tůma Z, Nalos L, Rajdl D, Štengl M, Kuncová J (2022) Mitochondrial dysfunction in kidney cortex and medulla of subtotally nephrectomized rats. Physiol Res 71:S219-26. https://doi.org/10.33549/physiolres.935000	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Rat	Kidney
Jedlicka 2022a Physiol Res	2022	Jedlička J, Tůma Z, Razak K, Kunc R, Kala A, Proskauer Pena S, Lerchner T, Ježek K, Kuncová J (2022) Impact of aging on mitochondrial respiration in various organs. https://doi.org/10.33549/physiolres.934995	LEAK ROUTINE OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue Homogenate Intact cells	Rat	Heart Skeletal muscle Nervous system Liver Kidney Platelet
Cruz-Gregorio 2022 Antioxidants (Basel)	2022	Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Medina-Campos ON, Sciutto E, Fragoso G, Pedraza-Chaverri J (2022) GK-1 Induces oxidative stress, mitochondrial dysfunction, decreased membrane potential, and impaired autophagy flux in a mouse model of breast cancer. https://doi.org/10.3390/antiox12010056	LEAK OXPHOS	N ROX	Isolated mitochondria	Mouse	Endothelial;epithelial;mesothelial cell
Lemminger 2022 Antioxidants (Basel)	2022	Lemminger AK, Fiorenza M, Eibye K, Bangsbo J, Hostrup M (2022) High-intensity exercise training alters the effect of N-acetylcysteine on exercise-related muscle ionic shifts in men. https://doi.org/10.3390/antiox12010053	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Spielmann 2022 Mamm Genome	2022	Spielmann N, Schenkl C, Komlódi T, da Silva-Buttkus P, Heyne E, Rohde J, Amarie OV, Rathkolb B, Gnaiger E, Doenst T, Fuchs H, Gailus-Durner V, de Angelis MH, Szibor M (2022) Knockout of the Complex III subunit Uqcrh causes bioenergetic impairment and cardiac contractile dysfunction. Mamm Genome 10.1007/s00335-022-09973-w	LEAK OXPHOS ET	N S NS ROX	Intact organism Isolated mitochondria	Mouse	Heart
Lehto 2022 Neurochem Res	2022	Lehto A, Koch K, Barnstorf-Brandes J, Viel C, Fuchs M, Klein J (2022) ß-Hydroxybutyrate improves mitochondrial function after transient ischemia in the mouse. https://doi.org/10.1007/s11064-022-03637-6	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Siow 2022 J Cell Sci	2022	Siow WX, Kabiri Y, Tang R, Chao YK, Plesch E, Eberhagen C, Flenkenthaler F, Fröhlich T, Bracher F, Grimm C, Biel M, Zischka H, Vollmar AM, Bartel K (2022) Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells. https://doi.org/10.1242/jcs.259455	LEAK OXPHOS	N S ROX	Permeabilized cells	Mouse	Liver
Vandenberg 2022 Am J Physiol Cell Physiol	2022	Vandenberg GG, Thotakura A, Scott AL (2022) Mitochondrial bioenergetics of astrocytes in Fragile X syndrome: new perspectives on culture conditions and sex effects. Am J Physiol Cell Physiol 322:C125-35. https://doi.org/10.1152/ajpcell.00130.2021	LEAK OXPHOS	N S CIV NS ROX	Permeabilized cells	Mouse	Nervous system
Patyal 2022 Int J Mol Sci	2022	Patyal P, Nguyen B, Zhang X, Azhar G, Ameer FS, Verma A, Crane J, Kc G, Che Y, Wei JY (2022) Rho/SRF inhibitor modulates mitochondrial functions. https://doi.org/10.3390/ijms231911536	LEAK ROUTINE OXPHOS ET	N S CIV ROX	Permeabilized cells Intact cells	Mouse	Skeletal muscle
Kleinwaechter 2022 RSC Chem Biol	2022	Kleinwaechter I, Mohr B, Joppe A, Hellmann N, Bereau T, Osiewacz HD, Schneider D (2022) CLiB - a novel cardiolipin-binder isolated via data-driven and in vitro screening. RSC Chem Biol 3:941-54. https://doi.org/10.1039/d2cb00125j	LEAK OXPHOS	N ROX	Isolated mitochondria	Fungi
Bresciani 2022 J Hepatol	2022	Bresciani N, Demagny H, Lemos V, Pontanari F, Li X, Sun Y, Li H, Perino A, Auwerx J, Schoonjans K (2022) The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis. https://doi.org/10.1016/j.jhep.2022.05.040	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Mouse	Liver
Xu 2022 Nat Commun	2022	Xu Z, Fu T, Guo Q, Zhou D, Sun W, Zhou Z, Chen X, Zhang J, Liu L, Xiao L, Yin Y, Jia Y, Pang E, Chen Y, Pan X, Fang L, Zhu MS, Fei W, Lu B, Gan Z (2022) Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength. https://doi.org/10.1038/s41467-022-28557-5	LEAK OXPHOS ET	N S ROX	Isolated mitochondria	Mouse	Skeletal muscle
Dias 2022 Free Radic Biol Med	2022	Dias C, Lourenço CF, Laranjinha J, Ledo A (2022) Modulation of oxidative neurometabolism in ischemia/reperfusion by nitrite. https://doi.org/10.1016/j.freeradbiomed.2022.11.021	ROUTINE OXPHOS ET	N S ROX	Permeabilized tissue Intact cells	Rat	Nervous system
Brun 2022 Plant Direct	2022	Brun A, Smokvarska M, Wei L, Chay S, Curie C, Mari S (2022) MCO1 and MCO3, two putative ascorbate oxidases with ferroxidase activity, new candidates for the regulation of apoplastic iron excess in Arabidopsis. https://doi.org/10.1002/pld3.463		ROX	Intact organism Intact cells	Saccharomyces cerevisiae
Fedorov 2022 Naunyn Schmiedebergs Arch Pharmacol	2022	Fedorov A, Lehto A, Klein J (2022) Inhibition of mitochondrial respiration by general anesthetic drugs. https://doi.org/10.1007/s00210-022-02338-9	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Quast 2022 Basic Res Cardiol	2022	Quast C, Kober F, Becker K, Zweck E, Hoffe J, Jacoby C, Flocke V, Gyamfi-Poku I, Keyser F, Piayda K, Erkens R, Niepmann S, Adam M, Baldus S, Zimmer S, Nickenig G, Grandoch M, Bönner F, Kelm M, Flögel U (2022) Multiparametric MRI identifies subtle adaptations for demarcation of disease transition in murine aortic valve stenosis. https://doi.org/10.1007/s00395-022-00936-5	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Heart
Graham 2022 Physiol Rep	2022	Graham ZA, DeBerry JJ, Cardozo CP, Bamman MM (2022) SS-31 does not prevent or reduce muscle atrophy 7 days after a 65 kdyne contusion spinal cord injury in young male mice. https://doi.org/10.14814/phy2.15266	LEAK OXPHOS ET	N ROX	Permeabilized tissue	Mouse	Skeletal muscle
Scrima 2022 Stem Cell Res Ther	2022	Scrima R, Agriesti F, Pacelli C, Piccoli C, Pucci P, Amoresano A, Cela O, Nappi L, Tataranni T, Mori G, Formisano P, Capitanio N (2022) Myoglobin expression by alternative transcript in different mesenchymal stem cells compartments. https://doi.org/10.1186/s13287-022-02880-6	ROUTINE	ROX	Intact cells	Human	Stem cells
Garcia-Roche 2022 J Dairy Sci	2022	García-Roche M, Talmón D, Cañibe G, Astessiano AL, Mendoza A, Quijano C, Cassina A, Carriquiry M (2022) Differential hepatic mitochondrial function and gluconeogenic gene expression in 2 Holstein strains in a pasture-based system. https://doi.org/10.3168/jds.2021-21358	LEAK OXPHOS ET	N S NS ROX	Intact cells	Bovines	Liver
Broome 2022 Redox Biol	2022	Broome SC, Pham T, Braakhuis AJ, Narang R, Wang HW, Hickey AJR, Mitchell CJ, Merry TL (2022) MitoQ supplementation augments acute exercise-induced increases in muscle PGC1α mRNA and improves training-induced increases in peak power independent of mitochondrial content and function in untrained middle-aged men. https://doi.org/10.1016/j.redox.2022.102341	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Melin 2022 JHEP Rep	2022	Melin N, Yarahmadov T, Sanchez-Taltavull D, Birrer FE, Brodie TM, Petit B, Felser A, Nuoffer JM, Montani M, Vozenin MC, Herrmann E, Candinas D, Aebersold DM, Stroka D (2022) A new mouse model of radiation-induced liver disease reveals mitochondrial dysfunction as an underlying fibrotic stimulus. https://doi.org/10.1016/j.jhepr.2022.100508	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Mouse	Liver
Kluckova 2022 Hemasphere	2022	Kluckova K, Clear AJ, D'Avola A, Rassenti LZ, Kipps TJ, Gribben JG, Riches JC (2022) B-cell receptor signaling induced metabolic alterations in chronic lymphocytic leukemia can be partially bypassed by TP53 abnormalities. https://doi.org/10.1097/hs9.0000000000000722	LEAK ET	ROX	Intact cells		Blood cells
Spagnuolo 2022 Mol Neurobiol	2022	Spagnuolo MS, Mazzoli A, Nazzaro M, Troise AD, Gatto C, Tonini C, Colardo M, Segatto M, Scaloni A, Pallottini V, Iossa S, Cigliano L (2022) Long-lasting Impact of sugar intake on neurotrophins and neurotransmitters from adolescence to young adulthood in rat frontal cortex. https://doi.org/10.1007/s12035-022-03115-8	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Leibold 2022 PLoS One	2022	Leibold S, Bagivalu Lakshminarasimha A, Gremse F, Hammerschmidt M, Michel M (2022) Long-term obesogenic diet leads to metabolic phenotypes which are not exacerbated by catch-up growth in zebrafish. https://doi.org/10.1371/journal.pone.0267933	LEAK OXPHOS ET	N ROX	Isolated mitochondria	Zebrafish
Tremmel 2022 Sci Rep	2022	Tremmel DM, Sackett SD, Feeney AK, Mitchell SA, Schaid MD, Polyak E, Chlebeck PJ, Gupta S, Kimple ME, Fernandez LA, Odorico JS (2022) A human pancreatic ECM hydrogel optimized for 3-D modeling of the islet microenvironment. https://doi.org/10.1038/s41598-022-11085-z	LEAK ROUTINE ET	ROX	Intact cells	Human	Islet cell;pancreas;thymus
Della Noce 2022 J Biol Chem	2022	Della Noce B, Martins da Silva R, de Carvalho Uhl MV, Konnai S, Ohashi K, Calixto C, Arcanjo A, de Abreu LA, de Carvalho SS, da Silva Vaz I Jr, Logullo C (2022) Redox imbalance induces remodeling of glucose metabolism in Rhipicephalus microplus embryonic cell line. https://doi.org/10.1016/j.jbc.2022.101599	LEAK ROUTINE ET	ROX	Intact cells	Chelicerates	Other cell lines
Siewiera 2022 Int J Mol Sci	2022	Siewiera K, Labieniec-Watala M, Kassassir H, Wolska N, Polak D, Watala C (2022) Potential role of mitochondria as modulators of blood platelet activation and reactivity in diabetes and effect of metformin on blood platelet bioenergetics and platelet activation. https://doi.org/10.3390/ijms23073666	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Rat	Platelet
Lee 2022 Hum Mol Genet	2022	Lee RG, Balasubramaniam S, Stentenbach M, Kralj T, McCubbin T, Padman B, Smith J, Riley LG, Priyadarshi A, Peng L, Nuske MR, Webster R, Peacock K, Roberts P, Stark Z, Lemire G, Ito YA; Care4Rare Canada Consortium, Boycott KM, Geraghty MT, van Klinken JB, Ferdinandusse S, Zhou Y, Walsh R, Marcellin E, Thorburn DR, Rosciolli T, Fletcher J, Rackham O, Vaz FM, Reid GE, Filipovska A (2022) Deleterious variants in CRLS1 lead to cardiolipin deficiency and cause an autosomal recessive multi-system mitochondrial disease. https://doi.org/10.1093/hmg/ddac040	LEAK OXPHOS	N CIV ROX	Permeabilized cells	Human	Fibroblast
Salazar-Petres 2022 Biol Reprod	2022	Salazar-Petres E, Pereira-Carvalho D, Lopez-Tello J, Sferruzzi-Perri AN (2022) Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice†. https://doi.org/10.1093/biolre/ioac056	LEAK OXPHOS ET	F N S CIV NS ROX	Permeabilized tissue	Mouse	Genital
Peugnet 2022 Antioxidants (Basel)	2022	Peugnet V, Chwastyniak M, Mulder P, Lancel S, Bultot L, Fourny N, Renguet E, Bugger H, Beseme O, Loyens A, Heyse W, Richard V, Amouyel P, Bertrand L, Pinet F, Dubois-Deruy E (2022) Mitochondrial-targeted therapies require mitophagy to prevent oxidative stress induced by SOD2 inactivation in hypertrophied cardiomyocytes. https://doi.org/10.3390/antiox11040723	LEAK ROUTINE ET	ROX	Intact cells	Rat	Heart
Bina 2022 Mol Cell Biochem	2022	Bînă AM, Aburel OM, Avram VF, Lelcu T, Lința AV, Chiriac DV, Mocanu AG, Bernad E, Borza C, Craina ML, Popa ZL, Muntean DM, Crețu OM (2022) Impairment of mitochondrial respiration in platelets and placentas: a pilot study in preeclamptic pregnancies. https://doi.org/10.1007/s11010-022-04415-2	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Isolated mitochondria Intact cells	Human	Genital Platelet
Yin 2022 J Exp Med	2022	Yin Y, Xu D, Mao Y, Xiao L, Sun Z, Liu J, Zhou D, Xu Z, Liu L, Fu T, Ding C, Guo Q, Sun W, Zhou Z, Yang L, Jia Y, Chen X, Gan Z (2022) FNIP1 regulates adipocyte browning and systemic glucose homeostasis in mice by shaping intracellular calcium dynamics. https://doi.org/10.1084/jem.20212491	LEAK OXPHOS	F N S ROX	Permeabilized cells	Mouse	Fat
Starr 2022 Curr Res Physiol	2022	Starr VJ, Dzialowski EM (2022) Developing chicken cardiac muscle mitochondria are resistant to variations in incubation oxygen levels. https://doi.org/10.1016/j.crphys.2022.03.001	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Chicken	Heart
Hansen 2022 Magn Reson Med	2022	Hansen K, Hansen ESS, Jespersen NRV, Bøtker HE, Pedersen M, Wang T, Laustsen C (2022) Hyperpolarized ¹³C MRI reveals large changes in pyruvate metabolism during digestion in snakes. https://doi.org/10.1002/mrm.29239	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Reptiles	Liver
Munoz-Pujol 2022 Brain Pathol	2022	Muñoz-Pujol G, Ortigoza-Escobar JD, Paredes-Fuentes AJ, Jou C, Ugarteburu O, Gort L, Yubero D, García-Cazorla A, O'Callaghan M, Campistol J, Muchart J, Yépez VA, Gusic M, Gagneur J, Prokisch H, Artuch R, Ribes A, Urreizti R, Tort F (2022) Leigh syndrome is the main clinical characteristic of PTCD3 deficiency. https://doi.org/10.1111/bpa.13134	LEAK ROUTINE ET	ROX	Intact cells	Human	Fibroblast
Petry 2022 Antioxidants (Basel)	2022	Petry SF, Römer A, Rawat D, Brunner L, Lerch N, Zhou M, Grewal R, Sharifpanah F, Sauer H, Eckert GP, Linn T (2022) Loss and recovery of glutaredoxin 5 is inducible by diet in a murine model of diabesity and mediated by free fatty acids in vitro. https://doi.org/10.3390/antiox11040788	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Mouse	Islet cell;pancreas;thymus
Soares 2022 Geroscience	2022	Soares RN, Ramirez-Perez FI, Cabral-Amador FJ, Morales-Quinones M, Foote CA, Ghiarone T, Sharma N, Power G, Smith JA, Rector RS, Martinez-Lemus LA, Padilla J, Manrique-Acevedo C (2022) SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice. https://doi.org/10.1007/s11357-022-00563-x	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Endothelial;epithelial;mesothelial cell
Marrocco 2021 J Immunol	2021	Marrocco A, Frawley K, Pearce LL, Peterson J, O'Brien JP, Mullett SJ, Wendell SG, St Croix CM, Mischler SE, Ortiz LA (2021) Metabolic adaptation of macrophages as mechanism of defense against crystalline silica. J Immunol 207:1627-40.	LEAK OXPHOS ET	N ROX		Mouse	Macrophage-derived
Valera-Alberni 2021 Cell Rep	2021	Valera-Alberni M, Joffraud M, Miro-Blanch J, Capellades J, Junza A, Dayon L, Núñez Galindo A, Sanchez-Garcia JL, Valsesia A, Cercillieux A, Söllner F, Ladurner AG, Yanes O, Cantó C (2021) Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation. Cell Rep 36:109565.	LEAK OXPHOS ET	N S NS ROX	Homogenate Isolated mitochondria	Mouse	Liver Fat
Branco Haas 2021 Thesis	2021	Branco Haas C (2021) Insulin signaling and microglia in the young and aged brain. PhD Thesis 135.	LEAK OXPHOS ET	N ROX	Intact cells
Bastos Sant'Anna Silva 2021 Cancers (Basel)	2021	Bastos Sant'Anna Silva AC, Perez Valencia JA, Sciacovelli M, Lalou C, Sarlak S, Tronci L, Nikitopoulou E, Meszaros AT, Frezza C, Rossignol R, Gnaiger E, Klocker H (2021) Succinate anaplerosis has an onco-driving potential in prostate cancer cells. https://doi.org/10.3390/cancers13071727	LEAK ROUTINE OXPHOS	S ROX	Permeabilized cells Intact cells	Human	Genital
Rossetti 2021 Sci Adv	2021	Rossetti G, Ermer JA, Stentenbach M, Siira SJ, Richman TR, Milenkovic D, Perks KL, Hughes LA, Jamieson E, Xiafukaiti G, Ward NC, Takahashi S, Gray N, Viola HM, Hool LC, Rackham O, Filipovska A (2021) A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance. Sci Adv 7:eabi7514.	LEAK OXPHOS ET	F N S ROX	Isolated mitochondria	Mouse	Liver
Zhang 2021 Pharmaceutics	2021	Zhang H, Zhang A, Gupte AA, Hamilton DJ (2021) Plumbagin elicits cell-specific cytotoxic effects and metabolic responses in melanoma cells. Pharmaceutics 13:706.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell Other cell lines
Kladnicka 2021 Biomolecules	2021	Kladnicka I, Cedikova M, Jedlicka J, Kohoutova M, Muller L, Plavinova I, Kripnerova M, Bludovska M, Kuncova J, Mullerova D (2021) Chronic DDE exposure modifies mitochondrial respiration during differentiation of human adipose-derived mesenchymal stem cells into mature adipocytes. Biomolecules 11:1068.	LEAK ROUTINE ET	ROX	Intact cells	Human	Fat
Scheffer 2021 Brain Commun	2021	Scheffer DDL, Freitas FC, Aguiar AS Jr, Ward C, Guglielmo LGA, Prediger RD, Cronin SJF, Walz R, Andrews NA, Latini A (2021) Impaired dopamine metabolism is linked to fatigability in mice and fatigue in Parkinson's disease patients. Brain Commun 3:fcab116.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Skeletal muscle
Gvozdjakova 2021 PLoS One	2021	Gvozdjáková A, Sumbalová Z, Kucharská J, Szamosová M, Čápová L, Rausová Z, Vančová O, Mojto V, Langsjoen P, Palacka P (2021) Platelet mitochondrial respiration and coenzyme Q₁₀ could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases. PLoS ONE 16:e0256135.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet
Alves 2021 Eur J Nutr	2021	Alves BL, Araújo TDR, Guimarães DSPSF, Zoppi CC, Figueiredo MS, Carneiro EM (2021) Amino acid restriction alters survival mechanisms in pancreatic beta cells: possible role of the PI3K/Akt pathway. Eur J Nutr 60:3947-57.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Islet cell;pancreas;thymus
McKenna 2021 Redox Biol	2021	McKenna HT, O'Brien KA, Fernandez BO, Minnion M, Tod A, McNally BD, West JA, Griffin JL, Grocott MP, Mythen MG, Feelisch M, Murray AJ, Martin DS (2021) Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness. Redox Biol 41:101907.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Apostolopoulou 2021 Sci Adv	2021	Apostolopoulou M, Mastrototaro L, Hartwig S, Pesta D, Straßburger K, de Filippo E, Jelenik T, Karusheva Y, Gancheva S, Markgraf D, Herder C, Nair KS, Reichert AS, Lehr S, Müssig K, Al-Hasani H, Szendroedi J, Roden M (2021) Metabolic responsiveness to training depends on insulin sensitivity and protein content of exosomes in insulin-resistant males. https://doi.org/10.1126/sciadv.abi9551	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Human	Skeletal muscle
Zunica 2021 Cancer Metab	2021	Zunica ERM, Axelrod CL, Cho E, Spielmann G, Davuluri G, Alexopoulos SJ, Beretta M, Hoehn KL, Dantas WS, Stadler K, King WT, Pergola K, Irving BA, Langohr IM, Yang S, Hoppel CL, Gilmore LA, Kirwan JP (2021) Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15. Cancer Metab 9:36.	LEAK OXPHOS ET	N S CIV NS ROX F DQ	Permeabilized cells Homogenate	Human Mouse	Endothelial;epithelial;mesothelial cell
Conceicao 2021 Sci Rep	2021	Conceição CC, da Silva JN, Arcanjo A, Nogueira CL, de Abreu LA, de Oliveira PL, Gondim KC, Moraes B, de Carvalho SS, da Silva RM, da Silva Vaz I Jr, Moreira LA, Logullo C (2021) Aedes fluviatilis cell lines as new tools to study metabolic and immune interactions in mosquito-Wolbachia symbiosis. Sci Rep 11:19202.	LEAK ROUTINE ET	ROX	Intact cells	Molluscs
Liu 2021 Basic Res Cardiol	2021	Liu N, Kataoka M, Wang Y, Pu L, Dong X, Fu X, Zhang F, Gao F, Liang T, Pei J, Xiao C, Qiu Q, Hong T, Chen Q, Zhao J, Zhu L, He J, Hu X, Nie Y, Zhu W, Yu H, Cowan DB, Hu X, Wang J, Wang DZ, Chen J (2021) LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway. Basic Res Cardiol 116:48.	OXPHOS	F N S CIV ROX	Permeabilized tissue	Mouse	Heart
Liang 2021 Biomed Pharmacother	2021	Liang L, Zhang G, Cheng C, Li H, Jin T, Su C, Xiao Y, Bradley J, Peberdy MA, Ornato JP, Mangino MJ, Tang W (2021) High-resolution respirometry for evaluation of mitochondrial function on brain and heart homogenates in a rat model of cardiac arrest and cardiopulmonary resuscitation. Biomed Pharmacother 142:111935.	LEAK OXPHOS ROUTINE	N S CIV ROX	Homogenate	Rat	Heart Nervous system
Cannon 2021 Respir Physiol Neurobiol	2021	Cannon DT, Nogueira L, Gutierrez-Gonzalez AK, Gilmore NK, Bigby TD, Breen EC (2021) Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416/hypoxia model of pulmonary hypertension. Respir Physiol Neurobiol 295:103783.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
King 2021 J Biol Chem	2021	King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, Tandler B, Pergola K, Hermann GE, Rogers RC, López-Domènech S, Dantas WS, Stadler K, Hoppel CL, Kirwan JP (2021) Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics. J Biol Chem 297:101196.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Hoppel 2021 Cells	2021	Hoppel F, Garcia-Souza LF, Kantner-Rumplmair W, Burtscher M, Gnaiger E, Pesta D, Calabria E (2021) Human platelet mitochondrial function reflects systemic mitochondrial alterations: a protocol for application in field studies. https://doi.org/10.3390/cells10082088	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet
Zuccarelli 2021 J Physiol	2021	Zuccarelli L, Baldassarre G, Magnesa B, Degano C, Comelli M, Gasparini M, Manferdelli G, Marzorati M, Mavelli I, Pilotto A, Porcelli S, Rasica L, Šimunič B, Pišot R, Narici M, Grassi B (2021) Peripheral impairments of oxidative metabolism after a 10-day bed rest are upstream of mitochondrial respiration. J Physiol 599:4813-29.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Oemer 2021 J Lipid Res	2021	Oemer G, Edenhofer ML, Wohlfarter Y, Lackner K, Leman G, Koch J, Cardoso LHD, Lindner HH, Gnaiger E, Dubrac S, Zschocke J, Keller MA (2021) Fatty acyl availability modulates cardiolipin composition and alters mitochondrial function in HeLa cells. https://doi.org/10.1016/j.jlr.2021.100111	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells	Human	HeLa
Gnaiger 2021 MitoFit BCA	2021	Gnaiger E (2021) Bioenergetic cluster analysis – mitochondrial respiratory control in human fibroblasts. MitoFit Preprints 2021.08. https://doi.org/10.26124/mitofit:2021-0008	LEAK OXPHOS ET	ROX	Intact cells	Human	Fibroblast
Mazzoli 2021 Nutrients	2021	Mazzoli A, Gatto C, Crescenzo R, Cigliano L, Iossa S (2021) Prolonged changes in hepatic mitochondrial activity and insulin sensitivity by high fructose intake in adolescent rats. Nutrients 13:1370.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Liver
Sladowska 2021 PLoS Biol	2021	Sladowska M, Turek M, Kim MJ, Drabikowski K, Mussulini BHM, Mohanraj K, Serwa RA, Topf U, Chacinska A (2021) Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans. PLoS Biol 19:3001302.	OXPHOS	N S CIV ROX	Isolated mitochondria	Caenorhabditis elegans
Bouche 2021 PLoS One	2021	Bouche L, Kamel R, Tamareille S, Garcia G, Villedieu C, Pillot B, Gueguen N, Chehaitly A, Chao de la Barca JM, Beaumont J, Baetz D, Ovize M, Sesaki H, Henrion D, Reynier P, Lenaers G, Prunier F, Mirebeau-Prunier D (2021) DRP1 haploinsufficiency attenuates cardiac ischemia/reperfusion injuries. PLoS One 16:0248554.	LEAK OXPHOS ET	N S CIV NS ROX F	Permeabilized tissue	Mouse	Heart
Dunn 2021 Arterioscler Thromb Vasc Biol	2021	Dunn LL, Kong SMY, Tumanov S, Chen W, Cantley J, Ayer A, Maghzal GJ, Midwinter RG, Chan KH, Ng MKC, Stocker R (2021) Hmox1 (heme oxygenase-1) protects against ischemia-mediated injury via stabilization of HIF-1α (hypoxia-inducible factor-1α). Arterioscler Thromb Vasc Biol 41:317-30.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Cretin 2021 EMBO Mol Med	2021	Cretin E, Lopes P, Vimont E, Tatsuta T, Langer T, Gazi A, Sachse M, Yu-Wai-Man P, Reynier P, Wai T (2021) High-throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts. EMBO Mol Med 13:13579.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Fibroblast
Avram 2021 Life (Basel)	2021	Avram VF, Bina AM, Sima A, Aburel OM, Sturza A, Burlacu O, Timar RZ, Muntean DM, Elmer E, Cretu OM (2021) Improvement of platelet respiration by cell-permeable succinate in diabetic patients treated with statins. Life (Basel) 11:288.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet
Herraez 2021 Pharmaceutics	2021	Herraez R, Quesada R, Dahdah N, Vinas M, Vinuesa T (2021) Tambjamines and prodiginines: Biocidal activity against Trypanosoma cruzi. Pharmaceutics 13:705.	ROUTINE	ROX	Intact cells	Protists
Fischer 2021 Antioxidants	2021	Fischer C, Volani C, Komlódi T, Seifert M, Demetz E, Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, Gnaiger E, Weiss G (2021) Dietary iron overload and Hfe^-/- related hemochromatosis alter hepatic mitochondrial function. https://doi.org/10.3390/antiox10111818	LEAK OXPHOS ET	ROX N S Gp		Mouse	Liver
Zanou 2021 Nat Commun	2021	Zanou N, Dridi H, Reiken S, Imamura de Lima T, Donnelly C, De Marchi U, Ferrini M, Vidal J, Sittenfeld L, Feige JN, Garcia-Roves PM, Lopez-Mejia IC, Marks AR, Auwerx J, Kayser B, Place N (2021) Acute RyR1 Ca²⁺ leak enhances NADH-linked mitochondrial respiratory capacity. Nat Commun 12:7219.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Skeletal muscle
Kruse 2021 Life (Basel)	2021	Kruse CJ, Stern D, Mouithys-Mickalad A, Niesten A, Art T, Lemieux H, Votion DM (2021) In vitro assays for the assessment of impaired mitochondrial bioenergetics in equine atypical myopathy. Life (Basel) 11:719.	LEAK OXPHOS ET	F N S NS ROX	Intact cells Permeabilized cells	Horse	Skeletal muscle
Siewiera 2021 Int J Mol Sci	2021	Siewiera K, Labieniec-Watala M, Wolska N, Kassassir H, Watala C (2021) Sample preparation as a critical aspect of blood platelet mitochondrial respiration measurements - The impact of platelet activation on mitochondrial respiration. https://doi.org/10.3390/ijms22179332	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Viel 2021 Pharmaceuticals (Basel)	2021	Viel C, Brandtner AT, Weißhaar A, Lehto A, Fuchs M, Klein J (2021) Effects of magnesium orotate, benfotiamine and a combination of vitamins on mitochondrial and cholinergic function in the TgF344-AD rat model of Alzheimer's disease. https://doi.org/10.3390/ph14121218	LEAK OXPHOS ET	N S CIV ROX	Isolated mitochondria	Rat	Nervous system
Lelcu 2021 Children (Basel)	2021	Lelcu T, Bînă AM, Dănilă MD, Popoiu CM, Aburel OM, Arghirescu ST, Borza C, Muntean DM (2021) Assessment of platelet mitochondrial respiration in a pediatric population: A pilot study in healthy children and children with acute lymphoblastic leukemia. https://doi.org/10.3390/children8121196	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Human	Platelet
Pharaoh 2021 JCSM Rapid Commun	2021	Pharaoh G, Brown J, Ranjit R, Ungvari Z, Van Remmen H (2021) Reduced adenosine diphosphate sensitivity in skeletal muscle mitochondria increases reactive oxygen species production in mouse models of aging and oxidative stress but not denervation. https://doi.org/10.1002/rco2.29	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Newsom 2021 Med Sci Sports Exerc	2021	Newsom SA, Stierwalt HD, Ehrlicher SE, Robinson MM (2021) Substrate-specific respiration of isolated skeletal muscle mitochondria after 1 h of moderate cycling in sedentary adults. https://doi.org/10.1249/mss.0000000000002615	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Human	Skeletal muscle
Jasz 2021 J Cell Mol Med	2021	Jász DK, Szilágyi ÁL, Tuboly E, Baráth B, Márton AR, Varga P, Varga G, Érces D, Mohácsi Á, Szabó A, Bozó R, Gömöri K, Görbe A, Boros M, Hartmann P (2021) Reduction in hypoxia-reoxygenation-induced myocardial mitochondrial damage with exogenous methane. https://doi.org/10.1111/jcmm.16498	LEAK ROUTINE OXPHOS ET	S ROX	Permeabilized cells Isolated mitochondria	Rat	Heart
Palacka 2021 Int J Mol Sci	2021	Palacka P, Gvozdjáková A, Rausová Z, Kucharská J, Slopovský J, Obertová J, Furka D, Furka S, Singh KK, Sumbalová Z (2021) Platelet mitochondrial bioenergetics reprogramming in patients with urothelial carcinoma. https://doi.org/10.3390/ijms23010388	LEAK ROUTINE OXPHOS ET	F N S Gp NS ROX	Permeabilized cells Intact cells	Human	Platelet
Elliehausen 2021 Exp Gerontol	2021	Elliehausen CJ, Minton DM, Nichol AD, Konopka AR (2021) Skeletal muscle mitochondrial respiration in a model of age-related osteoarthritis is impaired after dietary rapamycin. https://doi.org/10.1016/j.exger.2021.111579	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Guinea pig	Skeletal muscle
Kripnerova 2021 J Clin Med	2021	Kripnerová M, Parmar HS, Šána J, Kopková A, Radová L, Sopper S, Biernacki K, Jedlička J, Kohoutová M, Kuncová J, Peychl J, Rudolf E, Červinka M, Houdek Z, Dvořák P, Houfková K, Pešta M, Tůma Z, Dolejšová M, Tichánek F, Babuška V, Leba M, Slabý O, Hatina J (2021) Complex interplay of genes underlies invasiveness in fibrosarcoma progression model. J Clin Med 10:2297.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Fibroblast
Wuest 2021 Int J Mol Sci	2021	Wüst RCI, Coolen BF, Held NM, Daal MRR, Alizadeh Tazehkandi V, Baks-Te Bulte L, Wiersma M, Kuster DWD, Brundel BJJM, van Weeghel M, Strijkers GJ, Houtkooper RH (2021) The antibiotic doxycycline impairs cardiac mitochondrial and contractile function. Int J Mol Sci 22:4100.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Heart
Kumar 2021 JCI Insight	2021	Kumar A, Welch N, Mishra S, Bellar A, Silva RN, Li L, Singh SS, Sharkoff M, Kerr A, Chelluboyina AK, Sekar J, Attaway AH, Hoppel C, Willard B, Davuluri G, Dasarathy S (2021) Metabolic reprogramming during hyperammonemia targets mitochondrial function and postmitotic senescence. JCI Insight 6:e154089.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue Isolated mitochondria Intact cells	Mouse Rat	Skeletal muscle
Galli 2021 Front Physiol	2021	Galli GLJ, Ruhr IM, Crossley J, Crossley DA 2nd (2021) The long-term effects of developmental hypoxia on cardiac mitochondrial function in snapping turtles. Front Physiol 12:689684. doi: 10.3389/fphys.2021.689684	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Reptiles	Heart
Palzur 2021 Int J Mol Sci	2021	Palzur E, Edelman D, Sakas R, Soustiel JF (2021) Etifoxine restores mitochondrial oxidative phosphorylation and improves cognitive recovery following traumatic brain injury. Int J Mol Sci 22:12881. doi: 10.3390/ijms222312881	LEAK OXPHOS	N S ROX	Isolated mitochondria	Rat	Nervous system
Gomez-Valades 2021 Cell Metab	2021	Gómez-Valadés AG, Pozo M, Varela L, Boudjadja MB, Ramírez S, Chivite I, Eyre E, Haddad-Tóvolli R, Obri A, Milà-Guasch M, Altirriba J, Schneeberger M, Imbernón M, Garcia-Rendueles AR, Gama-Perez P, Rojo-Ruiz J, Rácz B, Alonso MT, Gomis R, Zorzano A, D'Agostino G, Alvarez CV, Nogueiras R, Garcia-Roves PM, Horvath TL, Claret M (2021) Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca²⁺ homeostasis with adipose tissue lipolysis . Cell Metab 33:1820-35.e9.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate	Mouse	Nervous system
Theall 2021 Physiol Rep	2021	Theall B, Stampley J, Cho E, Granger J, Johannsen NM, Irving BA, Spielmann G (2021) Impact of acute exercise on peripheral blood mononuclear cells nutrient sensing and mitochondrial oxidative capacity in healthy young adults. Physiol Rep 9:e15147.	LEAK ROUTINE OXPHOS ET	N NS ROX	Permeabilized cells Intact cells	Human	Blood cells
Riguet 2021 Nat Commun	2021	Riguet N, Mahul-Mellier AL, Maharjan N, Burtscher J, Croisier M, Knott G, Hastings J, Patin A, Reiterer V, Farhan H, Nasarov S, Lashuel HA (2021) Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties. Nat Commun 12:6579.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	HEK
Vernerova 2021 Biomedicines	2021	Vernerova A, Garcia-Souza LF, Soucek O, Kostal M, Rehacek V, Krcmova LK, Gnaiger E, Sobotka O (2021) Mitochondrial respiration of platelets: comparison of isolation methods. https://doi.org/10.3390/biomedicines9121859	LEAK ROUTINE ET	ROX	Intact cells	Human	Platelet
Tallosy 2021 Sci Rep	2021	Tallósy SP, Poles MZ, Rutai A, Fejes R, Juhász L, Burián K, Sóki J, Szabó A, Boros M, Kaszaki J (2021) The microbial composition of the initial insult can predict the prognosis of experimental sepsis. Sci Rep 11:22772.	LEAK OXPHOS	S ROX	Homogenate	Rat	Liver
Assis-de-Lemos 2021 Biosci Rep	2021	Assis-de-Lemos G, Monteiro J, Oliveira-Valença VM, Melo GA, Reis RAM, Rehen SK, Silveira MS, Galina A (2021) Dopamine signaling impairs ROS modulation by mitochondrial hexokinase in human neural progenitor cells. https://doi.org/10.1042/bsr20211191	LEAK ROUTINE ET	ROX	Intact cells	Human	Nervous system
Young 2021 J Biol Chem	2021	Young MP, Schug ZT, Booth DM, Yule DI, Mikoshiba K, Hajnóczky G, Joseph SK (2021) Metabolic adaptation to the chronic loss of Ca²⁺ signaling induced by knockout of IP 3 receptors or the mitochondrial Ca²⁺ uniporter. J Biol Chem 298:101436.	LEAK ROUTINE ET	ROX	Intact cells	Human	HEK HeLa
Antico 2021 Sci Adv	2021	Antico O, Ordureau A, Stevens M, Singh F, Nirujogi RS, Gierlinski M, Barini E, Rickwood ML, Prescott A, Toth R, Ganley IG, Harper JW, Muqit MMK (2021) Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1. Sci Adv 7:eabj0722.	LEAK OXPHOS ET	F N S Gp NS ROX	Intact cells	Mouse	Nervous system
Akinbiyi 2021 Sci Rep	2021	Akinbiyi EO, Abramowitz LK, Bauer BL, Stoll MSK, Hoppel CL, Hsiao CP, Hanover JA, Mears JA (2021) Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass. Sci Rep 11:22106.	LEAK OXPHOS ET	F N S DQ CIV NS ROX	Permeabilized cells
Ferreira 2021 Redox Biol	2021	Ferreira JJ, Cassina A, Irigoyen P, Ford M, Pietroroia S, Peramsetty N, Radi R, Santi CM, Sapiro R (2021) Increased mitochondrial activity upon CatSper channel activation is required for mouse sperm capacitation. https://doi.org/10.1016/j.redox.2021.102176	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Genital
Gupta 2021 Sci Rep	2021	Gupta MK, Sahu A, Sun Y, Mohan ML, Kumar A, Zalavadia A, Wang X, Martelli EE, Stenson K, Witherow CP, Drazba J, Dasarathy S, Naga Prasad SV (2021) Cardiac expression of microRNA-7 is associated with adverse cardiac remodeling. Sci Rep 11:22018.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Heart
Liepinsh 2021 Free Radic Biol Med	2021	Liepinsh E, Kuka J, Vilks K, Svalbe B, Stelfa G, Vilskersts R, Sevostjanovs E, Goldins NR, Groma V, Grinberga S, Plaas M, Makrecka-Kuka M, Dambrova M (2021) Low cardiac content of long-chain acylcarnitines in TMLHE knockout mice prevents ischaemia-reperfusion-induced mitochondrial and cardiac damage. Free Radic Biol Med 177:370-80.	LEAK OXPHOS	F N S NS ROX	Permeabilized tissue	Mouse	Heart
Liu 2021 FASEB J	2021	Liu Z, Chaillou T, Santos Alves E, Mader T, Jude B, Ferreira DMS, Hynynen H, Cheng AJ, Jonsson WO, Pironti G, Andersson DC, Kenne E, Ruas JL, Tavi P, Lanner JT (2021) Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force. FASEB J 35:e22010.	LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Hoene 2021 Mol Metab	2021	Hoene M, Kappler L, Kollipara L, Hu C, Irmler M, Bleher D, Hoffmann C, Beckers J, Hrabě de Angelis M, Häring HU, Birkenfeld AL, Peter A, Sickmann A, Xu G, Lehmann R, Weigert C (2021) Exercise prevents fatty liver by modifying the compensatory response of mitochondrial metabolism to excess substrate availability. Mol Metab 54:101359.	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Mouse	Liver
Mendham 2021 Diabetologia	2021	Mendham AE, Goedecke JH, Zeng Y, Larsen S, George C, Hauksson J, Fortuin-de Smidt MC, Chibalin AV, Olsson T, Chorell E (2021) Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity. Diabetologia 64:1642-59.	LEAK OXPHOS ET	F N S NS ROX	Intact cells	Human	Skeletal muscle
Avram 2021 Int J Mol Sci	2021	Avram VF, Chamkha I, Åsander-Frostner E, Ehinger JK, Timar RZ, Hansson MJ, Muntean DM, Elmér E (2021) Cell-permeable succinate rescues mitochondrial respiration in cellular models of statin toxicity. Int J Mol Sci 22:424.	ROUTINE ET LEAK	ROX	Intact cells	Human	Platelet
Terwilliger 2021 Vasc Med	2021	Terwilliger ZS, Ryan TE, Goldberg EJ, Schmidt CA, Yamaguchi DJ, Karnekar R, Brophy P, Green TD, Zeczycki TN, Mac Gabhann F, Annex BH, McClung JM (2021) Racial differences in the limb skeletal muscle transcriptional programs of patients with critical limb ischemia. Vasc Med 26:247-58.	OXPHOS LEAK	N S CIV ROX NS	Permeabilized tissue	Human	Skeletal muscle
Mukherjee 2021 JCI Insight	2021	Mukherjee S, Mo J, Paolella LM, Perry CE, Toth J, Hugo MM, Chu Q, Tong Q, Chellappa K, Baur JA (2021) SIRT3 is required for liver regeneration but not for the beneficial effect of nicotinamide riboside. JCI Insight 6:e14719.	OXPHOS	N S CIV ROX F	Isolated mitochondria	Mouse	Liver
Iadarola 2021 J Biol Chem	2021	Iadarola DM, Joshi A, Caldwell CB, Gohil VM (2021) Choline restores respiration in Psd1-deficient yeast by replenishing mitochondrial phosphatidylethanolamine. J Biol Chem 296:100539.	ET ROUTINE	ROX	Intact cells Intact organism	Saccharomyces cerevisiae
Ko 2021 Biomolecules	2021	Ko HJ, Tsai CY, Chiou SJ, Lai YL, Wang CH, Cheng JT, Chuang TH, Huang CF, Kwan AL, Loh JK, Hong YR (2021) The phosphorylation status of Drp1-Ser637 by PKA in mitochondrial fission modulates mitophagy via PINK1/Parkin to exert multipolar spindles assembly during mitosis. Biomolecules 11:424.	LEAK ROUTINE ET	ROX	Intact cells	Human	HeLa
Schumann 2021 Commun Biol	2021	Schumann T, Koenig J, von Loeffelholz C, Vatner DF, Zhang D, Perry RJ, Bernier M, Chami J, Henke C, Kurzbach A, El-Agroudy NN, Willmes DM, Pesta D, de Cabo R, O Sullivan JF, Simon E, Shulman GI, Hamilton BS, Birkenfeld AL (2021) Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Commun Biol 4:826.	LEAK ROUTINE OXPHOS ET	F N NS ROX	Intact cells	Mouse	Liver
Weiss 2021 Crit Care Explor	2021	Weiss SL, Bittinger K, Lee JJ, Friedman ES, Mattei LM, Graham K, Zhang D, Bush J, Balamuth F, McGowan FX Jr, Bushman FD, Baldassano RN, Wu GD, Wallace DC, Collman RG (2021) Decreased intestinal microbiome diversity in pediatric sepsis: a conceptual framework for intestinal dysbiosis to influence immunometabolic function. Crit Care Explor 3:0360.	LEAK ROUTINE ET	ROX	Intact cells	Human	Lymphocyte
Mazzoli 2021 Antioxidants (Basel)	2021	Mazzoli A, Spagnuolo MS, Nazzaro M, Gatto C, Iossa S, Cigliano L (2021) Fructose removal from the diet reverses inflammation, mitochondrial dysfunction, and oxidative stress in hippocampus. Antioxidants (Basel) 10:487.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Nervous system
Willis 2021 Sci Rep	2021	Willis JR, Hickey AJR, Devaux JBL (2021) Thermally tolerant intertidal triplefin fish (Tripterygiidae) sustain ATP dynamics better than subtidal species under acute heat stress. Sci Rep 11:11074.	LEAK OXPHOS ET ROUTINE	N ROX NS	Homogenate	Fishes	Nervous system
Dos Santos Escaliante 2021 Int J Biol Macromol	2021	Dos Santos Escaliante LA, Busato B, de Oliveira Petkowicz CL, Suter Correia Cadena SM, Rodrigues Noleto G (2021) Cytotoxic effect of xyloglucan and oxovanadium (IV/V) xyloglucan complex in HepG2 cells. Int J Biol Macromol 185:40-48.	LEAK OXPHOS	N S CIV ROX	Permeabilized cells	Human	Liver
Seefeldt 2021 Sci Rep	2021	Seefeldt JM, Lassen TR, Vognstoft Hjortbak M, Jespersen NR, Kvist F, Hansen J, Boetker HE (2021) Cardioprotective effects of empagliflozin after ischemia and reperfusion in rats. Sci Rep 11:9544.	LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Rat	Heart
Giovarelli 2021 Pharmacol Res	2021	Giovarelli M, Zecchini S, Catarinella G, Moscheni C, Sartori P, Barbieri C, Roux-Biejat P, Napoli A, Vantaggiato C, Cervia D, Perrotta C, Clementi E, Latella L, De Palma C (2021) Givinostat as metabolic enhancer reverting mitochondrial biogenesis deficit in Duchenne Muscular Dystrophy. Pharmacol Res 170:105751.	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Saura-Esteller 2021 Int J Mol Sci	2021	Saura-Esteller J, Sánchez-Vera I, Núñez-Vázquez S, Cosialls AM, Gama-Pérez P, Bhosale G, Mendive-Tapia L, Lavilla R, Pons G, Garcia-Roves PM, Duchen MR, Iglesias-Serret D, Gil J (2021) Activation of the integrated stress response and ER stress protect from fluorizoline-induced apoptosis in HEK293T and U2OS cell lines. Int J Mol Sci 22:6117.	LEAK ROUTINE ET	ROX	Intact cells	Human	Lymphocyte HEK
Sanchez-de-Diego 2021 Redox Biol	2021	Sánchez-de-Diego C, Pedrazza L, Pimenta-Lopes C, Martinez-Martinez A, Dahdah N, Valer JA, Garcia-Roves P, Rosa JL, Ventura F (2021) NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression. Redox Biol 40:101845.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Other cell lines
Wall 2021 Dis Model Mech	2021	Wall JM, Basu A, Zunica ERM, Dubuisson OS, Pergola K, Broussard JP, Kirwan JP, Axelrod CL, Johnson AE (2021) CRISPR/Cas9-engineered Drosophila knock-in models to study VCP diseases. Dis Model Mech 14:dmm048603.	LEAK OXPHOS ET	N S Gp CIV NS ROX	Permeabilized tissue	Drosophila	Skeletal muscle
Axelrod 2021 EMBO Mol Med	2021	Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP (2021) BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol Med 12:12088.	ROUTINE OXPHOS ET LEAK	F N S NS ROX DQ	Intact cells Permeabilized tissue	Mouse	Skeletal muscle
Furihata 2021 Commun Biol	2021	Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H, Kinugawa S (2021) Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure. Commun Biol 4:138.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Heart
Cardoso 2021 BEC MgG	2021	Cardoso LHD, Doerrier C, Gnaiger E (2021) Magnesium Green for fluorometric measurement of ATP production does not interfere with mitochondrial respiration. Bioenerg Commun 2021.1. https://doi.org/10.26124/bec:2021-0001	LEAK OXPHOS ET	N S ROX	Isolated mitochondria	Mouse	Heart
Goldberg 2021 Biochem J	2021	Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH (2021) Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform. Biochem J 476:1521-37.	LEAK OXPHOS ET	N S NS ROX F	Isolated mitochondria	Mouse	Heart Skeletal muscle Liver
Vidimce 2021 Front Pharmacol	2021	Vidimce J, Pillay J, Shrestha N, Dong LF, Neuzil J, Wagner KH, Holland OJ, Bulmer AC (2021) Mitochondrial function, fatty acid metabolism, and body composition in the hyperbilirubinemic gunn rat. Front Pharmacol 12:586715.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate	Rat	Skeletal muscle Liver
Baldini 2021 Life Sci	2021	Baldini F, Fabbri R, Eberhagen C, Voci A, Portincasa P, Zischka H, Vergani L (2021) Adipocyte hypertrophy parallels alterations of mitochondrial status in a cell model for adipose tissue dysfunction in obesity. Life Sci 265:118812.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Fibroblast
Holody 2021 Mitochondrion	2021	Holody C, Anfray A, Mast H, Lessard M, Han WH, Carpenter R, Bourque S, Sauvé Y, Lemieux H (2021) Differences in relative capacities of oxidative phosphorylation pathways may explain sex- and tissue-specific susceptibility to vision defects due to mitochondrial dysfunction. Mitochondrion 56:102-10.	LEAK OXPHOS	N S CIV NS ROX	Homogenate	Rat	Nervous system
Giordano 2021 Gene Ther	2021	Giordano L, Aneja MK, Sommer N, Alebrahimdehkordi N, Seraji A, Weissmann N, Rudolph C, Plank C, Jacobs HT, Szibor M (2021) Alternative oxidase encoded by sequence-optimized and chemically-modified RNA transfected into mammalian cells is catalytically active. https://doi.org/10.1038/s41434-021-00235-z	LEAK ROUTINE OXPHOS	N S CIV ROX	Permeabilized cells Intact cells	Mouse	Fibroblast
Flouda 2021 Free Radic Biol Med	2021	Flouda K, Mercer J, Davies MJ, Hawkins CL (2021) Role of myeloperoxidase-derived oxidants in the induction of vascular smooth muscle cell damage. Free Radic Biol Med 166:165-77.	LEAK ROUTINE ET	ROX	Intact cells	Human	Other cell lines
Wigner 2021 Sci Rep	2021	Wigner P, Zielinski K, Labieniec-Watala M, Marczak A, Szwed M (2021) Doxorubicin-transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells. Sci Rep 11:4544.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Other cell lines
Pamenter 2021 Biol Lett	2021	Pamenter ME, Gomez CR, Richards JG, Milsom WK (2021) Mitochondrial responses to prolonged anoxia in brain of red-eared slider turtles. Biol Lett 12:20150797.	LEAK OXPHOS ET	N S CIV ROX	Permeabilized cells	Reptiles	Nervous system
Thoral 2021 Biol Lett	2021	Thoral E, Roussel D, Chinopoulos C, Teulier L, Salin K (2021) Low oxygen levels can help to prevent the detrimental effect of acute warming on mitochondrial efficiency in fish. Biol Lett 17:20200759.	LEAK OXPHOS	N CIV NS ROX	Homogenate	Fishes	Skeletal muscle
Yardeni 2021 Proc Natl Acad Sci U S A	2021	Yardeni T, Cristancho AG, McCoy AJ, Schaefer PM, McManus MJ, Marsh ED, Wallace DC (2021) An mtDNA mutant mouse demonstrates that mitochondrial deficiency can result in autism endophenotypes. Proc Natl Acad Sci U S A 118:e2021429118.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Schmidt 2021 Cancer Metab	2021	Schmidt CA, McLaughlin KL, Boykov IN, Mojalagbe R, Ranganathan A, Buddo KA, Lin CT, Fisher-Wellman KH, Neufer PD (2021) Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells. Cancer Metab 9:3.	LEAK OXPHOS ET	N S Gp CIV ROX	Isolated mitochondria	Human	Liver
Meng 2021 FEBS Open Bio	2021	Meng L, Chen D, Meng G, Lu L, Han C (2021) Dysregulation of the Sirt5/IDH2 axis contributes to sunitinib resistance in human renal cancer cells. FEBS Open Bio 11:921-31.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Kidney
Klepinina 2021 PLoS One	2021	Klepinina L, Klepinin A, Truu L, Chekulayev V, Vija H, Kuus K, Teino I, Pook M, Maimets T, Kaambre T (2021) Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network. PLoS One 16:e0245348.	LEAK ROUTINE OXPHOS ET	N NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell
Hoppel 2021 Front Physiol	2021	Hoppel F, Calabria E, Pesta DH, Kantner-Rumplmair W, Gnaiger E, Burtscher M (2021) Effects of ultramarathon running on mitochondrial function of platelets and oxidative stress parameters: a pilot study. https://doi.org/10.3389/fphys.2021.632664	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet
Garcia 2021 J Steroid Biochem Mol Biol	2021	Garcia AM, Bishop EL, Li D, Jeffery LE, Garten A, Thakker A, Certo M, Mauro C, Tennant DA, Dimeloe S, Evelo CT, Coort SL, Hewison M (2021) Tolerogenic effects of 1,25-dihydroxyvitamin D on dendritic cells involve induction of fatty acid synthesis. J Steroid Biochem Mol Biol 211:105891.	LEAK ET ROUTINE	ROX	Intact cells	Human	Blood cells
Brodnanova 2021 Eur J Pharmacol	2021	Brodnanova M, Hatokova Z, Evinova A, Cibulka M, Racay P (2021) Differential impact of imipramine on thapsigargin- and tunicamycin-induced endoplasmic reticulum stress and mitochondrial dysfunction in neuroblastoma SH-SY5Y cells. Eur J Pharmacol 902:174073.	LEAK ROUTINE ET	N S ROX	Permeabilized cells Intact cells	Human	Neuroblastoma
Styles 2021 Cell Death Dis	2021	Styles FL, Al-Owais MM, Scragg JL, Chuntharpursat-Bon E, Hettiarachchi NT, Lippiat JD, Minard A, Bon RS, Porter K, Sukumar P, Peers C, Roberts LD (2021) Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism. Cell Death Dis 12:372.	LEAK ROUTINE ET	CIV ROX	Intact cells	Human	HEK
MacCannell 2021 Int J Obes (Lond)	2021	MacCannell ADV, Futers TS, Whitehead A, Moran A, Witte KK, Roberts LD (2021) Sexual dimorphism in adipose tissue mitochondrial function and metabolic flexibility in obesity. Int J Obes (Lond) 45:1773-81.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Fat
Watt 2021 Nat Commun	2021	Watt KI, Henstridge DC, Ziemann M, Sim CB, Montgomery MK, Samocha-Bonet D, Parker BL, Dodd GT, Bond ST, Salmi TM, Lee RS, Thomson RE, Hagg A, Davey JR, Qian H, Koopman R, El-Osta A, Greenfield JR, Watt MJ, Febbraio MA, Drew BG, Cox AG, Porrello ER, Harvey KF, Gregorevic P (2021) Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease. Nat Commun 12:2887.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
James 2021 Nat Commun	2021	James OJ, Vandereyken M, Marchingo JM, Singh F, Bray SE, Wilson J, Love AG, Swamy M (2021) IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes. Nat Commun 12:4290.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Mouse	Lymphocyte
Tungtur 2021 Sci Rep	2021	Tungtur SK, Wilkins HM, Rogers RS, Badawi Y, Sage JM, Agbas A, Jawdat O, Barohn RJ, Swerdlow RH, Nishimune H (2021) Oxaloacetate treatment preserves motor function in SOD1G93A mice and normalizes select neuroinflammation-related parameters in the spinal cord. Sci Rep 11:11051.	LEAK OXPHOS ET	N ROX	Isolated mitochondria	Mouse	Nervous system
Su 2021 Chin J Physiol	2021	Su Y, Wang Y, Xu P, Sun Y, Ping Z, Huang H, Cao X (2021) Study on the time-effectiveness of exercise preconditioning on heart protection in exhausted rats. Chin J Physiol 64:97-105.	LEAK OXPHOS	N S CIV NS ROX	Permeabilized tissue	Rat	Heart
Villanueva 2021 Transplant Direct	2021	Villanueva JE, Chew HC, Gao L, Doyle A, Scheuer SE, Hicks M, Jabbour A, Dhital KK, Macdonald PS (2021) The effect of increasing donor age on myocardial ischemic tolerance in a rodent model of donation after circulatory death. Transplant Direct 7:699.	LEAK OXPHOS ET	F N NS ROX S	Permeabilized tissue	Rat	Heart
Zhang 2021 PLOS ONE	2021	Zhang X, Yuan T, Keijer J, de Boer VCJ (2021) OCRbayes: a Bayesian hierarchical modeling framework for Seahorse extracellular flux oxygen consumption rate data analysis. PLOS ONE 16:e0253926.	LEAK ROUTINE ET	ROX			Fibroblast
Peruzzotti-Jametti 2021 PLoS Biol	2021	Peruzzotti-Jametti L, Bernstock JD, Willis CM, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Krzak G, Kittel A, Beninca C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Peacock B, Muller KH, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2021) Neural stem cells traffic functional mitochondria via extracellular vesicles. PLoS Biol 19:3001166.	LEAK OXPHOS	N S Gp CIV ROX	Permeabilized cells	Mouse	Nervous system Stem cells
Prieto-Carrasco 2021 Biology (Basel)	2021	Prieto-Carrasco R, Silva-Palacios A, Rojas-Morales P, Aparicio-Trejo OE, Medina-Reyes EI, Hernandez-Cruz EY, Sanchez-Garibay C, Salinas-Lara C, Pavon N, Roldan FJ, Zazueta C, Tapia E, Pedraza-Chaverri J (2021) Unilateral ureteral obstruction for 28 days in rats is not associated with changes in cardiac function or alterations in mitochondrial function. Biology (Basel) 10:671.	LEAK OXPHOS ET	N S ROX	Isolated mitochondria	Rat	Heart
Taylor 2021 Int J Mol Sci	2021	Taylor OJ, Thatcher MO, Carr ST, Gibbs JL, Trumbull AM, Harrison ME, Winden DR, Pearson MJ, Tippetts TS, Holland WL, Reynolds PR, Bikman BT (2021) High-mobility group box 1 disrupts metabolic function with cigarette smoke exposure in a ceramide-dependent manner. Int J Mol Sci 18:1099.	LEAK OXPHOS ET	N NS ROX	Permeabilized cells Permeabilized tissue	Mouse	Skeletal muscle
Chowdhury 2021 Cancers (Basel)	2021	Chowdhury SR, Peltier C, Hou S, Singh A, Johnston JB, Gibson SB, Marshall A, Banerji V (2021) Ex vivo mitochondrial respiration parallels biochemical response to ibrutinib in CLL cells. Cancers (Basel) 13:E354.	LEAK ROUTINE ET	ROX	Intact cells	Human	Lymphocyte
Kaspar 2021 Sci Adv	2021	Kaspar S, Oertlin C, Szczepanowska K, Kukat A, Senft K, Lucas C, Brodesser S, Hatzoglou M, Larsson O, Topisirovic I, Trifunovic A (2021) Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR. Sci Adv 7:0971.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Heart
Dorigatti 2021 Geroscience	2021	Dorigatti JD, Thyne KM, Ginsburg BC, Salmon AB (2021) Beta-guanidinopropionic acid has age-specific effects on markers of health and function in mice. Geroscience 43:1497-511.	LEAK OXPHOS ET	N S NS ROX F	Permeabilized tissue	Mouse	Skeletal muscle
Lei 2021 Ecotoxicol Environ Saf	2021	Lei C, Liao J, Li Q, Shi J, Zhang H, Guo J, Han Q, Hu L, Li Y, Pan J, Tang Z (2021) Copper induces mitochondria-mediated apoptosis via AMPK-mTOR pathway in hypothalamus of pigs. Ecotoxicol Environ Saf 220:112395.	LEAK OXPHOS ET	N S ROX		Pig	Nervous system
Leo 2021 Conserv Physiol	2021	Leo E, Dahlke FT, Storch D, Poertner HO, Mark FC (2021) Impact of ocean acidification and warming on the bioenergetics of developing eggs of atlantic herring Clupea harengus. Conserv Physiol 6:50.	ET	N ROX NS	Intact organism	Fishes
Jimenez-Uribe 2021 Free Radic Biol Med	2021	Jimenez-Uribe AP, Bellido B, Aparicio-Trejo OE, Tapia E, Sanchez-Lozada LG, Hernandez-Santos JA, Fernandez-Valverde F, Hernandez-Cruz EY, Orozco-Ibarra M, Pedraza-Chaverri J (2021) Temporal characterization of mitochondrial impairment in the unilateral ureteral obstruction model in rats. Free Radic Biol Med 172:358-71.	LEAK OXPHOS	N S ROX	Isolated mitochondria	Rat	Kidney
Basse 2021 Mol Metab	2021	Basse AL, Agerholm M, Farup J, Dalbram E, Nielsen J, Oertenblad N, Altıntas A, Ehrlich AM, Krag T, Bruzzone S, Dall M, de Guia RM, Jensen JB, Moeller AB, Karlsen A, Kjaer M, Barres R, Vissing J, Larsen S, Jessen N, Treebak JT (2021) Nampt controls skeletal muscle development by maintaining Ca²⁺ homeostasis and mitochondrial integrity. Mol Metab 53:101271.	LEAK OXPHOS	N CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Nedel 2021 Intensive Care Med Exp	2021	Nedel WL, Kopczynski A, Rodolphi MS, Strogulski NR, De Bastiani M, Montes THM, Abruzzi J Jr, Galina A, Horvath TL, Portela LV (2021) Mortality of septic shock patients is associated with impaired mitochondrial oxidative coupling efficiency in lymphocytes: a prospective cohort study. Intensive Care Med Exp 9:39.	LEAK OXPHOS	N NS ROX	Permeabilized cells	Human	Lymphocyte
Cheng 2021 Comp Biochem Physiol B Biochem Mol Biol	2021	Cheng H, Munro D, Huynh K, Pamenter ME (2021) Naked mole-rat skeletal muscle mitochondria exhibit minimal functional plasticity in acute or chronic hypoxia. Comp Biochem Physiol B Biochem Mol Biol 255:110596.	OXPHOS ET LEAK	F N S CIV NS ROX	Isolated mitochondria	Other mammals	Skeletal muscle
Sighel 2021 Cell Rep	2021	Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, Soldano A, Adami V, Ambrosini C, Broso F, Rosatti EF, Longhi S, Buccarelli M, D'Alessandris QG, Giannetti S, Pacioni S, Ricci-Vitiani L, Rorbach J, Pallini R, Roulland S, Amunts A, Mancini I, Modelska A, Quattrone A (2021) Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth. Cell Rep 35:109024.	ROUTINE OXPHOS	N S NS ROX	Permeabilized cells Intact cells	Human	Nervous system Stem cells
Babylon 2021 Antioxidants (Basel)	2021	Babylon L, Grewal R, Stahr PL, Eckert RW, Keck CM, Eckert GP (2021) Hesperetin nanocrystals improve mitochondrial function in a cell model of early Alzheimer disease. Antioxidants (Basel) 10:1003.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Neuroblastoma
Schroeder 2021 Cell Rep	2021	Schroeder S, Hofer SJ, Zimmermann A, Pechlaner R, Dammbrueck C, Pendl T, Marcello GM, Pogatschnigg V, Bergmann M, Mueller M, Gschiel V, Ristic S, Tadic J, Iwata K, Richter G, Farzi A, Uecal M, Schaefer U, Poglitsch M, Royer P, Mekis R, Agreiter M, Toelle RC, Sotonyi P, Willeit J, Mairhofer B, Niederkofler H, Pallhuber I, Rungger G, Tilg H, Defrancesco M, Marksteiner J, Sinner F, Magnes C, Pieber TR, Holzer P, Kroemer G, Carmona-Gutierrez D, Scorrano L, Dengjel J, Madl T, Sedej S, Sigrist SJ, Racz B, Kiechl S, Eisenberg T, Madeo F (2021) Dietary spermidine improves cognitive function. Cell Rep 35:108985.	LEAK OXPHOS ET	N NS ROX S	Homogenate	Mouse Drosophila	Nervous system
Burska 2021 Biochim Biophys Acta Mol Basis Dis	2021	Burska D, Stiburek L, Krizova J, Vanisova M, Martinek V, Sladkova J, Zamecnik J, Honzik T, Zeman J, Hansikova H, Tesarova M (2021) Homozygous missense mutation in UQCRC2 associated with severe encephalomyopathy, mitochondrial complex III assembly defect and activation of mitochondrial protein quality control. Biochim Biophys Acta Mol Basis Dis 1867:166147.	LEAK OXPHOS ET	CIV NS ROX N S	Permeabilized cells	Human	Fibroblast
Hansen 2021 Physiol Rep	2021	Hansen C, Olsen K, Pilegaard H, Bangsbo J, Gliemann L, Hellsten Y (2021) High metabolic substrate load induces mitochondrial dysfunction in rat skeletal muscle microvascular endothelial cells. Physiol Rep 9:e14855.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Rat	Skeletal muscle Endothelial;epithelial;mesothelial cell
MiPNet21.17 BloodCellsIsolation	2020-10-22	O2k-Protocols: Isolation of blood cells for HRR.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Intact cells Permeabilized cells	Human	Blood cells Platelet
Cipullo 2020 Nucleic Acids Res	2020	Cipullo M, Pearce SF, Lopez Sanchez IG, Gopalakrishna S, Krüger A, Schober F, Busch JD, Li X, Wredenberg A, Atanassov I, Rorbach J (2020) Human GTPBP5 is involved in the late stage of mitoribosome large subunit assembly. Nucleic Acids Res 49:354-70.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	HEK
Gnaiger 2020 BEC MitoPathways	2020	Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5^th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria Intact cells	Human Mouse	Heart Skeletal muscle Fibroblast
Burtscher 2020 Int J Mol Sci	2020	Burtscher J, Di Pardo A, Maglione V, Schwarzer C, Squitieri F (2020) Mitochondrial respiration changes in R6/2 Huntington's Disease model mice during aging in a brain region specific manner. Int J Mol Sci 21:5412.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Mouse	Nervous system
Mahul-Mellier 2020 Proc Natl Acad Sci U S A	2020	Mahul-Mellier AL, Burtscher J, Maharjan N, Weerens L, Croisier M, Kuttler F, Leleu M, Knott GW, Lashuel HA (2020) The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration. Proc Natl Acad Sci U S A 117:4971-82.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Mouse	Nervous system
Jaber 2020 BM Exp Neurol	2020	Jaber SM, Yadava N, Polster BM (2020) Mapping mitochondrial respiratory chain deficiencies by respirometry: beyond the Mito Stress Test. BM Exp Neurol 328:113282.	LEAK ROUTINE ET	ROX	Intact cells		Nervous system
Juarez-Flores 2020 Antioxidants (Basel)	2020	Juarez-Flores DL, Ezquerra M, Gonzalez-Casacuberta I, Ormazabal A, Moren C, Tolosa E, Fucho R, Guitart-Mampel M, Casado M, Valldeoriola F, de la Torre-Lara J, Munoz E, Tobias E, Compta Y, Garcia-Garcia FJ, Garcia-Ruiz C, Fernandez-Checa JC, Marti MJ, Grau JM, Cardellach F, Artuch R, Fernandez-Santiago R, Garrabou G (2020) Disrupted mitochondrial and metabolic plasticity underlie comorbidity between age-related and degenerative disorders as Parkinson disease and type 2 diabetes mellitus. Antioxidants (Basel) 9:1063.	LEAK ROUTINE ET	ROX	Permeabilized cells Intact cells	Human	Fibroblast
Makrecka-Kuka 2020 Sci Rep	2020	Makrecka-Kuka M, Dimitrijevs P, Domracheva I, Jaudzems K, Dambrova M, Arsenyan P (2020) Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production. https://doi.org/10.1038/s41598-020-78620-8.	LEAK OXPHOS	N S NS ROX	Permeabilized cells	Mouse	Endothelial;epithelial;mesothelial cell
Madeo 2020 US Patent	2020	Madeo F, Eisenberg T, Stekovic S (2020) Use of spermidine for the enhancement of mitochondrial respiration. US Patent US20200054579 A1.	LEAK OXPHOS ET	N ROX	Isolated mitochondria	Mouse	Heart
Woessner 2020 Thesis	2020	Woessner MN (2020) BEET-HF: The effects of dietary inorganic nitrate supplementation on aerobic exercise performance, vascular function, cardiac performance and mitochondrial respiration in patients with heart failure with reduced ejection fraction. PhD Thesis 198.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Burtscher 2020 eNeuro	2020	Burtscher J, Copin JC, Sandi C, Lashuel HA (2020) Pronounced α-synuclein pathology in a seeding-based mouse model is not sufficient to induce mitochondrial respiration deficits in the striatum and amygdala. eNeuro 7:ENEURO.0110-20.2020.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Kuffner 2020 Cells	2020	Kuffner K, Triebelhorn J, Meindl K, Benner C, Manook A, Sudria-Lopez D, Siebert R, Nothdurfter C, Baghai TC, Drexler K, Berneburg M, Rupprecht R, Milenkovic VM, Wetzel CH (2020) Major depressive disorder is associated with impaired mitochondrial function in skin fibroblasts. Cells 9:884. doi: 10.3390/cells9040884	LEAK ROUTINE ET	ROX	Intact cells	Human	Fibroblast
Hedges 2020 Biosci Rep	2020	Hedges CP, Pham T, Shetty B, Masson SWC, Hickey AJR, Shepherd PR, Merry TL (2020) Prolonged treatment with a PI3K p110α inhibitor causes sex- and tissue-dependent changes in antioxidant content, but does not affect mitochondrial function. https://doi.org/10.1042/bsr20201128	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle Liver
Plecita-Hlavata 2020 Antioxid Redox Signal	2020	Plecitá-Hlavatá L, Engstová H, Holendová B, Tauber J, Špaček T, Petrásková L, Křen V, Špačková J, Gotvaldová K, Ježek J, Dlasková A, Smolková K, Ježek P (2020) Mitochondrial superoxide production decreases on glucose-stimulated insulin secretion in pancreatic β cells due to decreasing mitochondrial matrix NADH/NAD⁺ ratio. Antioxid Redox Signal 33:789-815.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Islet cell;pancreas;thymus
Esselun 2020 Neuromolecular Med	2020	Esselun C, Dilberger B, Silaidos CV, Koch E, Schebb NH, Eckert GP (2020) A walnut diet in combination with enriched environment improves cognitive function and affects lipid metabolites in brain and liver of aged NMRI mice. Neuromolecular Med 23:140-60.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Mouse	Nervous system
Fuchs 2020 J Funct Foods	2020	Fuchs C, Bakuradze T, Steinke R, Grewal R, Eckert GP, Richling E (2020) Polyphenolic composition of extracts from winery by-products and effects on cellular cytotoxicity and mitochondrial functions in HepG2 cells. J Funct Foods 70:103988.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Liver
Mezeiova 2020 Eur J Med Chem	2020	Mezeiova E, Janockova J, Andrys R, Soukup O, Kobrlova T, Muckova L, Pejchal J, Simunkova M, Handl J, Micankova P, Capek J, Rousar T, Hrabinova M, Nepovimova E, Marco-Contelles JL, Valko M, Korabecny J (2020) 2-Propargylamino-naphthoquinone derivatives as multipotent agents for the treatment of Alzheimer's disease. Eur J Med Chem 211:113112.	LEAK OXPHOS ET	ROX	Intact cells	Human	Neuroblastoma
Rodriguez de Yurre 2020 An Acad Bras Cienc	2020	Rodriguez de Yurre A, Martins EGL, Lopez-Alarcon M, Cabral B, Vera N, Lopes JA, Galina A, Takiya CM, Lindoso RS, Vieyra A, SÁenz OC, Medei E (2020) Type 2 diabetes mellitus alters cardiac mitochondrial content and function in a non-obese mice model. An Acad Bras Cienc 92:e20191340.	LEAK OXPHOS	N NS ROX	Isolated mitochondria	Mouse	Heart
Residual oxygen consumption	2020	Gnaiger E (2020) Residual oxygen consumption: a baseline correction of mitochondrial respiration. Mitochondr Physiol Network (2016-01-28) last update 2020-11-11.		ROX
Ayari 2020 Commun Biol	2020	Ayari Asma, Rosa-Calatrava Manuel, Lancel Steve, Barthelemy Johanna, Pizzorno Andres, Mayeuf-Louchart Alicia, Baron Morgane, Hot David, Deruyter Lucie, Soulard Daphnee, Julien Thomas, Faveeuw Christelle, Molendi-Coste Olivier, Dombrowicz David, Sedano Laura, Sencio Valentin, Le Goffic Ronan, Trottein Francois, Wolowczuk Isabelle (2020) Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues. Commun Biol 3:237.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Fat
Makrecka-Kuka 2020 Cardiovasc Drugs Ther	2020	Makrecka-Kuka Marina, Korzh Stanislava, Videja Melita, Vilks Karlis, Cirule Helena, Kuka Janis, Dambrova Maija, Liepinsh Edgars (2020) Empagliflozin protects cardiac mitochondrial fatty acid metabolism in a mouse model of diet-induced lipid overload. Cardiovasc Drugs Ther 34:791-97.	OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Heart
Owiredu 2020 Am J Physiol Cell Physiol	2020	Owiredu S, Ranganathan A, Eckmann DM, Shofer FS, Hardy K, Lambert DS, Kelly M, Jang DH (2020) Ex vivo use of cell-permeable succinate prodrug attenuates mitochondrial dysfunction in blood cells obtained from carbon monoxide poisoned individuals. Am J Physiol Cell Physiol 319:C129-35.	LEAK ROUTINE ET	S CIV ROX	Permeabilized cells Intact cells	Human	Blood cells
BEC 2020.1 doi10.26124bec2020-0001.v1	2020	Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1	LEAK OXPHOS ET	F N S Gp DQ CIV NS Other combinations ROX	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria
Fecker 2020 Biomolecules	2020	Fecker R, Buda V, Alexa E, Avram S, Pavel IZ, Muntean D, Cocan I, Watz C, Minda D, Dehelean CA, Soica C, Danciu C (2020) Phytochemical and biological screening of Oenothera biennis L. hydroalcoholic extract. Biomolecules 10:E818.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Endothelial;epithelial;mesothelial cell
Pham 2020 Eur J Appl Physiol	2020	Pham T, MacRae CL, Broome SC, D'souza RF, Narang R, Wang HW, Mori TA, Hickey AJR, Mitchell CJ, Merry TL (2020) MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men. Eur J Appl Physiol 120:1657-69.	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized tissue	Human	Skeletal muscle
Fisher 2020 Placenta	2020	Fisher J, McKeating D, Pennell E, Cuffe J, Holland O, Perkins A (2020) Mitochondrial isolation, cryopreservation and preliminary biochemical characterisation from placental cytotrophoblast and syncytiotrophoblast. Placenta 82:1-4.	LEAK OXPHOS ET	N NS ROX	Isolated mitochondria	Human	Genital
Schleier 2020 J Cardiovasc Transl Res	2020	Schleier Y, Moreno-Loaiza O, López Alarcón MM, Lopes Martins EG, Braga BC, Ramos IP, Galina A, Medei EH (2020) NOD mice recapitulate the cardiac disturbances observed in type 1 diabetes. J Cardiovasc Transl Res 14:271-82.	LEAK OXPHOS	N NS ROX	Isolated mitochondria	Mouse	Heart
Keppner 2020 Thesis	2020	Keppner G (2020) Impact of gut microbiota composition, liver metabolism and respiratory capacity of peripheral blood mononuclear cells on resting metabolic rate. PhD Thesis 100.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Blood cells
Rondot 2020 Thesis	2020	Rondot A (2020) Fuels for winter: the role of proline in overwintering bumblebee queens (Bombus impatiens). Master's Thesis 41.	LEAK OXPHOS	N S NS ROX	Permeabilized tissue	Hexapods	Skeletal muscle
Oliveira 2020 Anim Reprod	2020	Oliveira VS, Castro AJG, Domingues JT, Souza AZP, Scheffer DL, Latini A, Soares CHL, Van Der Kraak G, Silva FRMB (2020) A brazilian pulp and paper mill effluent disrupts energy metabolism in immature rat testis and alters sertoli cell secretion and mitochondrial activity. Anim Reprod 17:e20190116.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Genital
Souza da Silva 2020 Mol Neurobiol	2020	Souza da Silva J, Nonose Y, Rohden F, Lukasewicz Ferreira PC, Fontella FU, Rocha A, Wigner Brochier A, Vieira Apel R, de Lima TM, Seminotti B, Amaral AU, Galina A, Souza DO (2020) Guanosine neuroprotection of presynaptic mitochondrial calcium homeostasis in a mouse study with amyloid-β oligomers. Mol Neurobiol 57:4790-809.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Falcao-Tebas 2020 J Physiol	2020	Falcão-Tebas F, Marin EC, Kuang J, Bishop DJ, McConell GK (2020) Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring. J Physiol 598:4251-70.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Rat	Skeletal muscle
Dulac 2020 J Physiol	2020	Dulac M, Leduc-Gaudet JP, Reynaud O, Ayoub MB, Guérin A, Finkelchtein M, Hussain SN, Gouspillou G (2020) Drp1 knockdown induces severe muscle atrophy and remodelling, mitochondrial dysfunction, autophagy impairment and denervation . J Physiol 598:3691-710.	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Severo 2020 Life Sci	2020	Severo L, Godinho D, Machado F, Hartmann D, Fighera MR, Soares FA, Furian AF, Oliveira MS, Royes LF (2020) The role of mitochondrial bioenergetics and oxidative stress in depressive behavior in recurrent concussion model in mice. Life Sci 257:117991.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Irion 2020 Stem Cells Int	2020	Irion CI, Martins EL, Christie MLA, de Andrade CBV, de Moraes ACN, Ferreira RP, Pimentel CF, Suhett GD, Campos de Carvalho AC, Lindoso RS, Vieyra A, Galina A, Goldenberg RCS (2020) Acute myocardial infarction reduces respiration in rat cardiac fibers, despite adipose tissue mesenchymal stromal cell transplant. Stem Cells Int 2020:4327965 .	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Rat	Heart
Dawid 2020 Biochim Biophys Acta Bioenerg	2020	Dawid C, Weber D, Musiol E, Janas V, Baur S, Lang R, Fromme T (2020) Comparative assessment of purified saponins as permeabilization agents during respirometry. Biochim Biophys Acta Bioenerg 1861:148251.	LEAK ROUTINE OXPHOS ET	N S Gp NS ROX	Permeabilized cells Isolated mitochondria Intact cells	Human Mouse	Nervous system HEK
Jespersen 2020 Sci Rep	2020	Jespersen NR, Hjortbak MV, Lassen TR, Støttrup NB, Johnsen J, Tonnesen PT, Larsen S, Kimose HH, Bøtker HE (2020) Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus. Sci Rep 10:10344.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Rat	Heart
Macedo 2020 FASEB J	2020	Macedo F, Romanatto T, Gomes de Assis C, Buis A, Kowaltowski AJ, Aguilaniu H, Marques da Cunha F (2020) Lifespan-extending interventions enhance lipid-supported mitochondrial respiration in Caenorhabditis elegans. FASEB J 34:9972-81.	LEAK OXPHOS	F N CIV ROX	Intact organism Isolated mitochondria	Caenorhabditis elegans
Pajuelo 2020 Cells	2020	Pajuelo Reguera D, Čunátová K, Vrbacký M, Pecinová A, Houštěk J, Mráček T, Pecina P (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:443.	LEAK OXPHOS ET	N S Gp CIV NS ROX	Permeabilized cells	Human	HEK
Wei 2020 Cell Rep	2020	Wei X, Lu Z, Li L, Zhang H, Sun F, Ma H, Wang L, Hu Y, Yan Z, Zheng H, Yang G, Liu D, Tepel M, Gao P, Zhu Z (2020) Reducing NADPH synthesis counteracts diabetic nephropathy through restoration of AMPK activity in type 1 diabetic rats. Cell Rep 32:108207.	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Rat	Kidney
Mouithys-Mickalad 2020 Chem Biol Interact	2020	Mouithys-Mickalad A, Ceusters J, Charif M, El Moualij B, Schoumacher M, Plyte S, Franck T, Bettendorff L, Pirotte B, Serteyn D, de Tullio P (2020) Modulation of mitochondrial respiration rate and calcium-induced swelling by new cromakalim analogues. Chem Biol Interact 331:109272.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Heart
Zulkifli 2020 Nat Commun	2020	Zulkifli M, Neff JK, Timbalia SA, Garza NM, Chen Y, Watrous JD, Murgia M, Trivedi PP, Anderson SK, Tomar D, Nilsson R, Madesh M, Jain M, Gohil VM (2020) Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism. Nat Commun 11:4866.	ROUTINE ET	ROX	Intact cells	Saccharomyces cerevisiae
Avila-Rojas 2020 Food Chem Toxicol	2020	Avila-Rojas SH, Aparicio-Trejo OE, Briones-Herrera A, Medina-Campos ON, Reyes-Fermín LM, Martínez-Klimova E, León-Contreras JC, Hernández-Pando R, Tapia E, Pedraza-Chaverri J (2020) Alterations in mitochondrial homeostasis in a potassium dichromate model of acute kidney injury and their mitigation by curcumin. Food Chem Toxicol 145:111774.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Rat	Kidney
Gumpp 2020 Proc Natl Acad Sci U S A	2020	Gumpp AM, Boeck C, Behnke A, Bach AM, Ramo-Fernández L, Welz T, Gündel H, Kolassa IT, Karabatsiakis A (2020) Childhood maltreatment is associated with changes in mitochondrial bioenergetics in maternal, but not in neonatal immune cells. Proc Natl Acad Sci U S A 117:24778-84.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Alahmad 2020 EMBO Mol Med	2020	Alahmad A, Nasca A, Heidler J, Thompson K, Oláhová M, Legati A, Lamantea E, Meisterknecht J, Spagnolo M, He L, Alameer S, Hakami F, Almehdar A, Ardissone A, Alston CL, McFarland R, Wittig I, Ghezzi D, Taylor RW (2020) Bi-allelic pathogenic variants in NDUFC2 cause early-onset Leigh syndrome and stalled biogenesis of complex I. EMBO Mol Med 12:e12619.	LEAK ROUTINE ET	ROX	Intact cells	Human	Fibroblast
Chen 2020 Chem Biol Interact	2020	Chen HY, Ho YJ, Chou HC, Liao EC, Tsai YT, Wei YS, Lin LH, Lin MW, Wang YS, Ko ML, Chan H (2020) TGF-β1 signaling protects retinal ganglion cells from oxidative stress via modulation of the HO-1/Nrf2 pathway. Chem Biol Interact 331:109249.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Nervous system
Visavadiya 2020 Mol Cell Biochem	2020	Visavadiya NP, Pena GS, Khamoui AV (2020) Mitochondrial dynamics and quality control are altered in a hepatic cell culture model of cancer cachexia. Mol Cell Biochem 476:23-34.	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells	Mouse	Liver
Bose 2020 Aging Cell	2020	Bose C, Alves I, Singh P, Palade PT, Carvalho E, Børsheim E, Jun SR, Cheema A, Boerma M, Awasthi S, Singh SP (2020) Sulforaphane prevents age-associated cardiac and muscular dysfunction through Nrf2 signaling. Aging Cell 19:e13261.	LEAK OXPHOS	F N CIV NS ROX	Permeabilized tissue	Mouse	Heart
Heinonen 2020 Sci Rep	2020	Heinonen I, Sorop O, van Dalen BM, Wüst RCI, van de Wouw J, de Beer VJ, Octavia Y, van Duin RWB, Hoogstrate Y, Blonden L, Alkio M, Anttila K, Stubbs A, van der Velden J, Merkus D, Duncker DJ (2020) Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement. Sci Rep 10:13173.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Pig	Heart
Larsen 2020 Cardiovasc Drugs Ther	2020	Larsen AH, Wiggers H, Dollerup OL, Jespersen NR, Hansson NH, Frøkiær J, Brøsen K, Nørrelund H, Bøtker HE, Møller N, Jessen N (2020) Metformin lowers body weight but fails to increase insulin sensitivity in chronic heart failure patients without diabetes: a randomized, double-blind, placebo-controlled study. Cardiovasc Drugs Ther 35:491-503.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Human	Skeletal muscle
Edmunds 2020 Mol Metab	2020	Edmunds LR, Xie B, Mills AM, Huckestein BR, Undamatla R, Murali A, Pangburn MM, Martin J, Sipula I, Kaufman BA, Scott I, Jurczak MJ (2020) Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance. Mol Metab 41:101051.	LEAK OXPHOS ET	F N ROX	Homogenate	Mouse	Liver
Guo 2020 Hum Gene Ther	2020	Guo Y, Zhang K, Gao X, Zhou Z, Liu Z, Yang K, Huang K, Yang Q, Long Q (2020) Sustained oligomycin sensitivity conferring protein expression in cardiomyocytes protects against cardiac hypertrophy induced by pressure-overload via improving mitochondrial function. Hum Gene Ther 31:1178-89.	LEAK OXPHOS ET	N NS ROX	Isolated mitochondria	Mouse	Heart
Pinho 2020 PLoS Negl Trop Dis	2020	Pinho N, Wiśniewski JR, Dias-Lopes G, Saboia-Vahia L, Bombaça ACS, Mesquita-Rodrigues C, Menna-Barreto R, Cupolillo E, de Jesus JB, Padrón G, Cuervo P (2020) In-depth quantitative proteomics uncovers specie-specific metabolic programs in Leishmania (Viannia) species. PLoS Negl Trop Dis 14:e0008509.		ROX	Intact cells	Protists	Other cell lines
Chang 2020 J Biol Chem	2020	Chang L, Liu X, Diggle CP, Boyle JP, Hopkins PM, Shaw MA, Allen PD (2020) Bioenergetic defects in muscle fibers of RYR1 mutant knock-in mice associated with malignant hyperthermia. J Biol Chem 295:15226-35.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Hoffmann 2020 J Clin Endocrinol Metab	2020	Hoffmann C, Schneeweiss P, Randrianarisoa E, Schnauder G, Kappler L, Machann J, Schick F, Fritsche A, Heni M, Birkenfeld A, Niess AM, Häring HU, Weigert C, Moller A (2020) Response of mitochondrial respiration in adipose tissue and muscle to 8 weeks of endurance exercise in obese subjects. J Clin Endocrinol Metab 105:dgaa571.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle Fat
Zhang 2020 Acta Pharmacol Sin	2020	Zhang L, Wang YN, Ju JM, Shabanova A, Li Y, Fang RN, Sun JB, Guo YY, Jin TZ, Liu YY, Li TY, Shan HL, Liang HH, Yang BF (2020) Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation. Acta Pharmacol Sin 42:691-700.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Heart
Anand 2020 Toxicol In Vitro	2020	Anand CR, Bhavya B, Jayakumar K, Harikrishnan VS, Gopala S (2020) Inorganic nitrite alters mitochondrial dynamics without overt changes in cell death and mitochondrial respiration in cardiomyoblasts under hyperglycemia. Toxicol In Vitro 70:105048.	LEAK ROUTINE ET	ROX	Intact cells	Rat	Heart
Herpich 2020 Exp Gerontol	2020	Herpich C, Franz K, Klaus S, Müller-Werdan U, Ost M, Norman K (2020) Age-related fatigue is associated with reduced mitochondrial function in peripheral blood mononuclear cells. Exp Gerontol 144:111177.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Rodriguez 2020 J Gerontol A Biol Sci Med Sci	2020	Rodríguez E, Hakkou M, Hagen TM, Lemieux H, Blier PU (2020) Divergences in the control of mitochondrial respiration are associated with lifespan variation in marine bivalves. J Gerontol A Biol Sci Med Sci 76:796-804.	LEAK OXPHOS ET	F N S Gp CIV ROX	Isolated mitochondria	Molluscs
Battaglia 2020 Cell Death Dis	2020	Battaglia CR, Cursano S, Calzia E, Catanese A, Boeckers TM (2020) Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons. Cell Death Dis 11:1004.	LEAK OXPHOS ET	N S CIV NS ROX	Intact cells	Rat	Nervous system
Charles 2020 Nanomedicine (Lond)	2020	Charles C, Cohen-Erez I, Kazaoka B, Melnikov O, Stein DE, Sensenig R, Rapaport H, Orynbayeva Z (2020) Mitochondrial responses to organelle-specific drug delivering nanoparticles composed of polypeptide and peptide complexes. Nanomedicine (Lond) 15:2917-32.	LEAK OXPHOS	N S CIV ROX	Isolated mitochondria	Human	Endothelial;epithelial;mesothelial cell
Contreras Mostazo 2020 Cancers (Basel)	2020	Mostazo MGC, Kurrle N, Casado M, Fuhrmann D, Alshamleh I, Häupl B, Martín-Sanz P, Brüne B, Serve H, Schwalbe H, Schnütgen F, Marin S, Cascante M (2020) Metabolic plasticity is an essential requirement of acquired tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Cancers (Basel) 12:E3443.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV ROX	Permeabilized cells Intact cells	Human	Blood cells
Kunz 2020 J Biol Chem	2020	Kunz HE, Dorschner JM, Berent TE, Meyer T, Wang X, Jatoi A, Kumar R, Lanza IR (2020) Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting. J Biol Chem 295:17441-59.	LEAK ROUTINE OXPHOS ET	N NS ROX S	Permeabilized tissue Intact cells	Mouse	Skeletal muscle
Fisher 2020 J Physiol	2020	Fisher JJ, Vanderpeet CL, Bartho LA, McKeating DR, Cuffe JSM, Holland OJ, Perkins AV (2020) Mitochondrial dysfunction in placental trophoblast cells experiencing gestational diabetes mellitus. J Physiol 599:1291-305.	OXPHOS ET	N NS ROX	Isolated mitochondria	Human	Genital
Palavicini 2020 JCI Insight	2020	Palavicini JP, Chen J, Wang C, Wang J, Qin C, Baeuerle E, Wang X, Woo JA, Kang DE, Musi N, Dupree JL, Han X (2020) Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes. JCI Insight 5:137286.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Nervous system
Rocha 2020 Sci Adv	2020	Rocha AL, de Lima TI, de Souza GP, Corrêa RO, Ferrucci DL, Rodrigues B, Lopes-Ramos C, Nilsson D, Knittel TL, Castro PR, Fernandes MF, Dos Santos Martins F, Parmigiani RB, Silveira LR, Carvalho HF, Auwerx J, Vinolo MAR, Boucher J, Mori MA (2020) Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression. Sci Adv 6:eabc6250.	LEAK ROUTINE ET	ROX	Intact cells	Mouse	Fat
Risiglione 2020 Int J Mol Sci	2020	Risiglione P, Leggio L, Cubisino SAM, Reina S, Paternò G, Marchetti B, Magrì A, Iraci N, Messina A (2020) High-resolution respirometry reveals MPP⁺ mitochondrial toxicity mechanism in a cellular model of parkinson's disease. Int J Mol Sci 21:E7809. https://doi.org/10.3390/ijms21217809	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Neuroblastoma
Weger 2020 Sci Rep	2020	Weger M, Alpern D, Cherix A, Ghosal S, Grosse J, Russeil J, Gruetter R, de Kloet ER, Deplancke B, Sandi C (2020) Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress. Sci Rep 10:18308.	OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
McLaughlin 2020b Sci Rep	2020	McLaughlin KL, Hagen JT, Coalson HS, Nelson MAM, Kew KA, Wooten AR, Fisher-Wellman KH (2020) Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs. Sci Rep 10:17599.	LEAK OXPHOS ET	F N S Gp CIV ROX	Isolated mitochondria	Mouse	Heart Liver Kidney Fat
Hroudova 2020 Mol Neurobiol	2020	Hroudová J, Nováková T, Korábečný J, Maliňák D, Górecki L, Fišar Z (2020) Effects of novel tacrine derivatives on mitochondrial energy metabolism and monoamine oxidase activity-in vitro study. Mol Neurobiol 58:1102-13.	OXPHOS	N S ROX	Isolated mitochondria	Pig	Nervous system
Lensu 2020 Nutrients	2020	Lensu S, Pariyani R, Mäkinen E, Yang B, Saleem W, Munukka E, Lehti M, Driuchina A, Lindén J, Tiirola M, Lahti L, Pekkala S (2020) Prebiotic xylo-oligosaccharides ameliorate high-fat-diet-induced hepatic steatosis in rats . Nutrients 12:E3225.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Rat	Liver
He 2020 Clin Transl Med	2020	He C, Gao P, Cui Y, Li Q, Li Y, Lu Z, Ma H, Zhao Y, Li L, Sun F, Chen, X, Jia H, Liu D, Yang G, Zheng H, Zhu Z (2020) Low‐glucose‐sensitive TRPC6 dysfunction drives hypoglycemia‐induced cognitive impairment in diabetes. Clin Transl Med 10:e205.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Nervous system
Simard 2020b Metabolites	2020	Simard CJ, Touaibia M, Allain EP, Hebert-Chatelain E, Pichaud N (2020) Role of the mitochondrial pyruvate carrier in the occurrence of metabolic inflexibility in Drosophila melanogaster exposed to dietary sucrose. Metabolites 10:E411.	LEAK OXPHOS ET	N Gp NS Other combinations ROX	Permeabilized tissue	Drosophila
Cheng 2020 Am J Physiol Heart Circ Physiol	2020	Cheng TC, Philip JL, Tabima DM, Kumari S, Yakubov B, Frump AL, Hacker TA, Bellofiore A, Li R, Sun X, Goss KN, Lahm T, Chesler N (2020) Estrogen receptor alpha prevents right ventricular diastolic dysfunction and fibrosis in female rats . Am J Physiol Heart Circ Physiol 319:H1459-73.	LEAK OXPHOS	N S CIV ROX	Permeabilized tissue	Rat	Heart
Romeiro 2020 bioRxiv	2020	Romeiro NC, Ferreira CM, Oliveira MF (2020) Assessment of mitochondrial physiology of murine white adipose tissue by mechanical permeabilization and lipid depletion. bioRxiv doi: https://doi.org/10.1101/2020.02.19.956870.	LEAK OXPHOS ET	S ROX	Permeabilized tissue	Mouse	Fat
Hijazi 2020 J Cell Sci	2020	Hijazi I, Knupp J, Chang A (2020) Retrograde signaling mediates an adaptive survival response to endoplasmic reticulum stress. J Cell Sci 133:jcs241539.	ROUTINE ET	ROX	Intact cells	Saccharomyces cerevisiae
De-Souza 2020 J Biol Chem	2020	De-Souza EA, Pimentel FSA, De-Queiroz ALFV, Camara H, Felix-Formiga ML, Machado CM, Pinto S, Galina A, Mori MA, Montero-Lomelí M, Masuda CA (2020) The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response. J Biol Chem 295:3773-82.	LEAK OXPHOS	N Gp NS ROX	Isolated mitochondria Intact cells	Caenorhabditis elegans Saccharomyces cerevisiae
Dawson 2020 J Exp Biol	2020	Dawson NJ, Millet C, Selman C, Metcalfe NB (2020) Measurement of mitochondrial respiration in permeabilized fish gills. J Exp Biol 223:jeb216762.	LEAK OXPHOS	N CIV NS ROX	Permeabilized tissue	Fishes	Lung;gill
Bombaca 2020 Free Radic Biol Med	2020	Bombaça ACS, Brunoro GVF, Dias-Lopes G, Ennes-Vidal V, Carvalho PC, Perales J, d'Avila-Levy CM, Valente RH, Menna-Barreto RFS (2020) Glycolytic profile shift and antioxidant triggering in symbiont-free and H₂O₂-resistant Strigomonas culicis. Free Radic Biol Med 146:392-401.		ROX	Intact cells	Protists
Pena 2020 Int J Chronic Dis	2020	Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Dis 2020:Article ID 5919501.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse	Nervous system
Padilla-Flores 2020 Biochem Biophys Res Commun	2020	Padilla-Flores T, Lopez-Gonzalez Z, Vaca L, Aparicio-Trejo OE, Briones-Herrera A, Riveros-Rosas H, Pedraza-Chaverri J, Leon-Aparicio D, Salvador C, Sampieri A, Escobar LI (2020) "Funny" channels in cardiac mitochondria modulate membrane potential and oxygen consumption. Biochem Biophys Res Commun 524:1030-36.	LEAK ROUTINE	ROX	Intact cells	Rat	Heart
Ost 2020 EMBO Rep	2020	Ost M, Igual Gil C, Coleman V, Keipert S, Efstathiou S, Vidic V, Weyers M, Klaus S (2020) Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress. EMBO Rep 21:e48804.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Stankova 2020 Int J Mol Sci	2020	Staňková P, Kučera O, Peterová E, Lotková H, Maseko TE, Nožičková K, Červinková Z (2020) Adaptation of mitochondrial substrate flux in a mouse model of nonalcoholic fatty liver disease. Int J Mol Sci 21:E1101.	LEAK OXPHOS	F N S Gp NS ROX	Homogenate	Mouse	Liver
Janowska 2020 Toxicol In Vitro	2020	Janowska JI, Piel S, Saliba N, Kim CD, Jang DH, Karlsson M, Kilbaugh TJ, Ehinger JK (2020) Mitochondrial respiratory chain Complex I dysfunction induced by N-methyl carbamate ex vivo can be alleviated with a cell-permeable succinate prodrug carbamate toxicity and treatment. Toxicol In Vitro 65:104794.	LEAK ROUTINE ET	N S NS ROX	Permeabilized cells Intact cells	Human	Platelet Blood cells
Ledur 2020 Sci Rep	2020	Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK (2020) Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep 10:1218.	LEAK ROUTINE ET	ROX	Intact cells	Human	Nervous system
Grewal 2020 Exp Neurol	2020	Grewal R, Reutzel M, Dilberger B, Hein H, Zotzel J, Marx S, Tretzel J, Sarafeddinov A, Fuchs C, Eckert GP (2020) Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing. Exp Neurol 328:113248.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Neuroblastoma
Cornelissen 2020 Hum Mol Genet	2020	Cornelissen T, Spinazzi M, Martin S, Imberechts D, Vangheluwe P, Bird M, De Strooper B, Vandenberghe W (2020) CHCHD2 harboring the Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Hum Mol Genet 29:1096-106.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Fibroblast
Dawson 2020 Exp Gerontol	2020	Dawson NJ, Salmón P (2020) Age-related increase in mitochondrial quantity may mitigate a decline in mitochondrial quality in red blood cells from zebra finches (Taeniopygia guttata). Exp Gerontol 133:110883.	LEAK ROUTINE ET	ROX	Intact cells	Birds	Blood cells
Schneider 2020 PLoS One	2020	Schneider J, Han WH, Matthew R, Sauve Y, Lemieux H (2020) Age and sex as confounding factors in the relationship between cardiac mitochondrial function and type 2 diabetes in the Nile Grass rat. PLoS One 15:e0228710.	LEAK OXPHOS	F N S CIV NS ROX	Permeabilized tissue	Rat	Heart
Frambach 2020 Biochim Biophys Acta Mol Basis Dis	2020	Frambach SJCM, van de Wal MAE, van den Broek PHH, Smeitink JAM, Russel FGM, de Haas R, Schirris TJJ (2020) Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice. Biochim Biophys Acta Mol Basis Dis 1866:165727.	LEAK OXPHOS	F N S Gp CIV Other combinations ROX	Permeabilized tissue	Mouse	Skeletal muscle
Szibor 2020 J Biol Chem	2020	Szibor Marten, Gizatullina Zemfira, Gainutdinov Timur, Endres Thomas, Debska-Vielhaber Grazyna, Kunz Matthias, Karavasili Niki, Hallmann Kerstin, Schreiber Frank, Bamberger Alexandra, Schwarzer Michael, Doenst Torsten, Heinze Hans-Jochen, Leßmann Volkmar, Vielhaber Stefan, Kunz Wolfram S, Gellerich Frank Norbert (2020) Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply. J Biol Chem 295:4383-97.	LEAK OXPHOS	N S Gp CIV NS ROX	Isolated mitochondria Intact cells	Mouse	Nervous system
Peruzzotti-Jametti 2020 bioRxiv	2020	Peruzzotti-Jametti L, Bernstock JD, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Kittel A, Benincá C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2020) Neural stem cells traffic functional mitochondria via extracellular vesicles to correct mitochondrial dysfunction in target cells. bioRxiv doi: https://doi.org/10.1101/2020.01.29.923441 .	LEAK	N S Gp CIV ROX	Permeabilized cells	Mouse	Stem cells
Groennebaek 2020 Cells	2020	Groennebaek T, Billeskov TB, Schytz CT, Jespersen NR, Bøtker HE, Olsen RKJ, Eldrup N, Nielsen J, Farup J, De Paoli FV, Vissing K (2020) Mitochondrial structure and function in the metabolic myopathy accompanying patients with critical limb ischemia. Cells 9:E570.	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Human	Skeletal muscle
Baxter 2020 Elife	2020	Baxter M, Voronkov M, Poolman T, Galli G, Pinali C, Goosey L, Knight A, Krakowiak K, Maidstone R, Iqbal M, Zi M, Prehar S, Cartwright EJ, Gibbs J, Matthews LC, Adamson AD, Humphreys NE, Rebelo-Guiomar P, Minczuk M, Bechtold DA, Loudon A, Ray D (2020) Cardiac mitochondrial function depends on BUD23 mediated ribosome programming. Elife 9:e50705.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Mouse	Heart
Doig 2020 Skelet Muscle	2020	Doig CL, Zielinska AE, Fletcher RS, Oakey LA, Elhassan YS, Garten A, Cartwright D, Heising S, Alsheri A, Watson DG, Prehn C, Adamski J, Tennant DA, Lavery GG (2020) Induction of the nicotinamide riboside kinase NAD⁺ salvage pathway in a model of sarcoplasmic reticulum dysfunction. Skelet Muscle 10:5.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Locatelli 2020 FASEB J	2020	Locatelli L, Cazzaniga A, De Palma C, Castiglioni S, Maier JAM (2020) Mitophagy contributes to endothelial adaptation to simulated microgravity. FASEB J 34:1833-45.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria Intact cells	Human	Endothelial;epithelial;mesothelial cell
Wang 2020 J Mol Med (Berl)	2020	Wang SY, Zhu Siyu, Wu Jian, Zhang Maomao, Xu Yousheng, Xu Wei, Cui Jinjin, Yu Bo, Cao Wei, Liu Jingjin (2020) Exercise enhances cardiac function by improving mitochondrial dysfunction and maintaining energy homoeostasis in the development of diabetic cardiomyopathy. J Mol Med (Berl) 98:245-61.	LEAK OXPHOS	N ROX	Isolated mitochondria	Mouse	Heart
Hraoui 2020 J Exp Biol	2020	Hraoui G, Bettinazzi S, Gendron AD, Boisclair D, Breton S (2020) Mitochondrial thermo-sensitivity in invasive and native freshwater mussels. J Exp Biol 223:jeb215921.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Molluscs	Lung;gill
Scrima 2020 bioRxiv	2020	Scrima R, Fugetto S, Capitanio N, Gatti DL (2020) Hemoglobin non-equilibrium oxygen dissociation curve. bioRxiv https://doi.org/10.1101/2020.01.09.900001.	LEAK	S ROX	Isolated mitochondria	Rat	Liver
Krajcova 2020 PLOS ONE	2020	Krajčová A, Urban T, Megvinet D, Waldauf P, Balík M, Hlavička J, Budera P, Janoušek L, Pokorná E, Duška F (2020) High resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle. PLOS ONE 15:e0226142. https://doi.org/10.1371/journal.pone.0226142	LEAK OXPHOS ET	N S NS ROX	Homogenate Isolated mitochondria	Human	Heart
Close 2020 Cells	2020	Close AF, Dadheech N, Lemieux H, Wang Q, Buteau J (2020) Disruption of beta-cell mitochondrial networks by the orphan nuclear receptor Nor1/Nr4a3. Cells 9:E168.	LEAK ROUTINE	N S CIV NS ROX	Permeabilized cells Intact cells	Rat	Islet cell;pancreas;thymus
Protasoni 2020 EMBO J	2020	Protasoni M, Pérez-Pérez R, Lobo-Jarne T, Harbour ME, Ding S, Peñas A, Diaz F, Moraes CT, Fearnley IM, Zeviani M, Ugalde C, Fernández-Vizarra E (2020) Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV. EMBO J 39:e102817.	LEAK ROUTINE ET	ROX	Intact cells	Human	Other cell lines
MitoEAGLE muscle 1	2020	Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. - Updated: 2020-03-08	LEAK OXPHOS ET	N NS S ROX	Permeabilized tissue	Human	Skeletal muscle
Kline 2020 Nitric Oxide	2020	Kline JA, Puskarich MA, Pike JW, Zagorski J, Alves NJ (2020) Inhaled nitric oxide to control platelet hyper-reactivity in patients with acute submassive pulmonary embolism. Nitric Oxide 96:20-8.	LEAK ET	ROX	Intact cells	Human	Platelet Blood cells
Purhonen 2020 Nat Commun	2020	Purhonen J, Grigorjev V, Ekiert R, Aho N, Rajendran J, Pietras R, Truvé K, Wikström M, Sharma V, Osyczka A, Fellman V, Kallijärvi J (2020) A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice. Nat Commun 11:322.	LEAK OXPHOS ET	N NS ROX	Isolated mitochondria	Mouse	Liver Kidney
MitoEAGLE blood cells 1	2020	Åsander Frostner Eleonor, Aburel Oana M, Avram Vlad F, Calabria Elisa, Castelo Rueda Maria Paulina, Chamkha Imen, Čižmárová Beata, Danila Maria-Daniela, Doerrier Carolina, Eckert Gunter P, Ehinger Johannes K, Elmer Eskil, Garcia-Souza Luiz F, Gnaiger Erich, Hoppel Florian, Karabatsiakis Alexander, Keppner Gloria, Kidere Dita, Krako Jakovljević Nina, Labieniec-Watala Magdalena, Lelcu Theia, Micankova Petra, Michalak Slawomir, Molina Anthony JA, Pavlovic Kasja, Pichler Irene, Piel Sarah, Rousar Tomas, Rybacka-Mossakowska Joanna, Schartner Melanie, Siewiera Karolina, Silaidos Carmina, Sjövall Fredrik, Sobotka Ondrej, Sumbalova Zuzana, Swiniuch Daria, Vernerova Andrea, Volani Chiara, Vujacic-Mirski Ksenija, Watala Cezary (2020) Interlaboratory guide to mitochondrial respiratory studies with peripheral blood mononuclear cells and platelets. - Updated: 2020-03-06 - *Confirmed	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Intact cells Permeabilized cells	Human	Blood cells Platelet
Liu 2020 Cell Death Dis	2020	Liu YF, Zhu Juan-Juan, Yu Tian X, Liu Han, Zhang Tao, Zhang Yun-Peng, Xie Si-An, Zheng Ming, Kong Wei, Yao Wei-Juan, Pang Wei, Zhao Chuan-Rong, Tang Yuan-Jun, Zhou Jing (2020) Hypermethylation of mitochondrial DNA in vascular smooth muscle cells impairs cell contractility. Cell Death Dis 11:35.	LEAK OXPHOS	N S CIV ROX	Permeabilized tissue	Mouse	Endothelial;epithelial;mesothelial cell
Evinova 2020 J Membr Biol	2020	Evinova A, Cizmarova B, Hatokova Z, Racay P (2020) High‑resolution respirometry in assessment of mitochondrial function in neuroblastoma SH‑SY5Y intact cells. J Membr Biol 253:129-36.	LEAK ROUTINE ET	N S ROX	Permeabilized cells Intact cells	Human	Neuroblastoma
Al-Azab 2020 FEBS J	2020	Al-Azab M, Qaed E, Ouyang X, Elkhider A, Walana W, Li H, Li W, Tang Y, Adlat S, Wei J, Wang B, Li X (2020) TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation. FEBS J 287:3088-104.	LEAK ROUTINE OXPHOS ET	N ROX	Permeabilized cells Intact cells	Human	Other cell lines
Nascimento-Dos-Santos 2020 Biochim Biophys Acta Mol Basis Dis	2020	Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linden R, Galina A, Petrs-Silva H (2020) Neuroprotection from optic nerve injury and modulation of oxidative metabolism by transplantation of active mitochondria to the retina. Biochim Biophys Acta Mol Basis Dis 1866:165686.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Isolated mitochondria Intact cells	Rat	Liver Nervous system
Tepp 2020 Biochim Biophys Acta Gen Subj	2020	Tepp K, Puurand M, Timohhina N, Aid-Vanakova J, Reile I, Shevchuk I, Chekulayev V, Eimre M, Peet N, Kadaja L, Paju K, Kaambre T (2020) Adaptation of striated muscles to Wolframin deficiency in mice: Alterations in cellular bioenergetics. Biochim Biophys Acta Gen Subj 1864:129523.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Mouse	Heart Skeletal muscle
Chen 2020 Biochim Biophys Acta Mol Basis Dis	2020	Chen T, Hill JT, Moore TM, Cheung ECK, Olsen ZE, Piorczynski TB, Marriott TD, Tessem JS, Walton CM, Bikman BT, Hansen JM, Thomson DM (2020) Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance. Biochim Biophys Acta Mol Basis Dis 1866:165805.	LEAK OXPHOS ET	N NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Woessner 2020 J Appl Physiol (1985)	2020	Woessner MN, Neil C, Saner NJ, Goodman CA, McIlvenna LC, Ortiz de Zevallos J, Garnham AP, Levinger I, Allen JD (2020) Effect of inorganic nitrate on exercise capacity, mitochondria respiration and vascular function in heart failure reduced ejection fraction. J Appl Physiol (1985) 128:1355-64.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
McCann 2020 Metabolites	2020	McCann MR, McHugh CE, Kirby M, Jennaro TS, Jones AE, Stringer KA, Puskarich MA (2020) A multivariate metabolomics method for estimating platelet mitochondrial oxygen consumption rates in patients with sepsis. Metabolites 10:E139.	LEAK ROUTINE ET	ROX	Intact cells	Human	Platelet
Piel 2020 PLoS One	2020	Piel S, Chamkha I, Dehlin AK, Ehinger JK, Sjövall F, Elmér E, Hansson MJ (2020) Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose. PLoS One 15:e0231173.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Liver Platelet
Almoiliqy 2020 Acta Pharmacol Sin	2020	Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y (2020) Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53. Acta Pharmacol Sin 41:1208-22.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Rat	Endothelial;epithelial;mesothelial cell
Carvalho 2020 BMC Nutr	2020	Carvalho E, Adams SH, Borsheim E, Blackburn ML, Ono-Moore KD, Cotter M, Bowlin AK, Yeruva L (2020) Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk. BMC Nutr 6:13.	LEAK OXPHOS	N NS ROX	Permeabilized tissue	Pig	Liver
Silaidos 2020 Mitochondrion	2020	Silaidos C, Grube J, Muley C, Eckert GP (2020) Time-dependent melatonin secretion is associated with mitochondrial function in peripheral blood mononuclear cells (PBMC) of male volunteers. Mitochondrion 53:21-29.	LEAK ROUTINE OXPHOS ET	N S CIV NS ROX	Permeabilized cells Intact cells	Human	Blood cells
Briones-Herrera 2020 Free Radic Biol Med	2020	Briones-Herrera A, Ramírez-Camacho I, Zazueta C, Tapia E, Pedraza-Chaverri J (2020) Altered proximal tubule fatty acid utilization, mitophagy, fission and supercomplexes arrangement in experimental Fanconi syndrome are ameliorated by sulforaphane-induced mitochondrial biogenesis. Free Radic Biol Med 153:54-70.	LEAK OXPHOS	F N S NS ROX	Isolated mitochondria	Rat	Kidney
Ulgherait 2020 Nat Commun	2020	Ulgherait Matt, Chen Anna, McAllister Sophie F, Kim Han X, Delventhal Rebecca, Wayne Charlotte R, Garcia Christian J, Recinos Yocelyn, Oliva Miles, Canman Julie C, Picard Martin, Owusu-Ansah Edward, Shirasu-Hiza Mimi (2020) Circadian regulation of mitochondrial uncoupling and lifespan. Nat Commun 11:1927.	LEAK OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Drosophila
Kanellopoulos 2020 Cell	2020	Kanellopoulos AK, Mariano V, Spinazzi M, Woo YJ, McLean C, Pech U, Li KW, Armstrong JD, Giangrande A, Callaerts P, Smit AB, Abrahams BS, Fiala A, Achsel T, Bagni C (2020) Aralar sequesters GABA into hyperactive mitochondria, causing social behavior deficits. Cell 180:1178-97.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Drosophila	Nervous system Other cell lines
Zussman 2020 J Autoimmun	2020	Zussman R, Xu LY, Damani T, Groom KM, Chen Q, Seers B, Viall CA, Chamley LW, Hickey A (2020) Antiphospholipid antibodies can specifically target placental mitochondria and induce ROS production. J Autoimmun 111:102437.	LEAK ET	N S Gp CIV NS ROX	Permeabilized tissue	Human	Genital
Feng 2020 Int J Biol Macromol	2020	Feng Q, Shao M, Han J, Tang T, Zhang Y, Liu F (2020) TFAM, a potential oxidative stress biomarker used for monitoring environment pollutants in Musca domestica. Int J Biol Macromol 155:524-34.	LEAK OXPHOS	N S ROX	Isolated mitochondria	Hexapods
Hassan 2020 MitoFit Preprint Arch	2020	Hassan Hazirah, Gnaiger Erich, Zakaria Fazaine, Makpol Suzana, Abdul Karim Norwahidah (2020) Alterations in mitochondrial respiratory capacity and membrane potential: a link between mitochondrial dysregulation and autism. https://doi.org/10.26124/mitofit:200003	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human
Reutzel 2020 Oxid Med Cell Longev	2020	Reutzel M, Grewal R, Dilberger B, Silaidos C, Joppe A, Eckert GP (2020) Cerebral mitochondrial function and cognitive performance during aging: A longitudinal study in NMRI mice. Oxid Med Cell Longev 2020:4060769.	LEAK ET OXPHOS	N S CIV ROX	Isolated mitochondria	Mouse	Nervous system
Franco 2020 bioRxiv	2020	Franco JLM, Genoula M, Corral D, Duette G, Ferreyra M, Maio M, Dolotowicz MB, Aparicio-Trejo OE, Patiño-Martínez E, Fuentes F, Soldan V, Moraña EJ, Palmero D, Ostrowski M, Schierloh P, Sánchez-Torres C, Hernández-Pando R, Pedraza-Chaverri J, Rombouts Y, Layre E, Hudrisier D, Vérollet C, Neyrolles O, Sasiain MC, Lugo-Villarino G, Balboa L (2020) Host-derived lipids from tuberculous pleurisy impair macrophage microbicidal-associated metabolic activity. bioRxiv doi: https://doi.org/10.1101/2020.03.23.001818 .	LEAK ROUTINE	N S CIV ROX	Intact cells	Human	Macrophage-derived
Aparicio-Trejo 2020 Free Radic Biol Med	2020	Aparicio-Trejo OE, Avila-Rojas SH, Tapia E, Rojas-Morales P, León-Contreras JC, Martínez-Klimova E, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2020) Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid. Free Radic Biol Med 154:18-32.	LEAK OXPHOS	F N S ROX	Isolated mitochondria	Rat	Kidney
Jian 2020 Cell Metab	2020	Jian C, Fu J, Cheng X, Shen LJ, Ji YX, Wang X, Pan S, Tian H, Tian S, Liao R, Song K, Wang HP, Zhang X, Wang Y, Huang Z, She ZG, Zhang XJ, Zhu L, Li H (2020) Low-dose sorafenib acts as a mitochondrial uncoupler and ameliorates nonalcoholic steatohepatitis. Cell Metab 31:892-908. https://doi.org/10.1016/j.cmet.2020.04.011	LEAK OXPHOS ET	N S CIV ROX	Permeabilized cells	Mouse	Liver
De Souza 2020 Heliyon	2020	De Souza CEA, Andrade Pires AR, Cardoso CR, Carlos RM, Cadena SMSC, Acco A (2020) Antineoplastic activity of a novel ruthenium complex against human hepatocellular carcinoma (HepG2) and human cervical adenocarcinoma (HeLa) cells. Heliyon 6:e03862.	LEAK ROUTINE ET	ROX	Intact cells	Human	Liver HeLa
Yadav 2020 Cell Death Dis	2020	Yadav SK, Kambis TN, Kar S, Park SY, Mishra PK (2020) MMP9 mediates acute hyperglycemia-induced human cardiac stem cell death by upregulating apoptosis and pyroptosis in vitro. Cell Death Dis 11:186.	LEAK OXPHOS ET	N CIV NS ROX	Permeabilized cells	Human	Heart Stem cells
Brand 2020 J Clin Med	2020	Brand S, Ebner K, Mikoteit T, Lejri I, Gerber M, Beck J, Holsboer-Trachsler E, Eckert A (2020) Influence of regular physical activity on mitochondrial activity and symptoms of burnout-an interventional pilot study. J Clin Med 9:E667.	LEAK OXPHOS ET	N CIV ROX	Permeabilized cells	Human	Lymphocyte
Vulczak 2020 Cells	2020	Vulczak A, Souza AO, Ferrari GD, Azzolini AECS, Pereira-da-Silva G, Alberici LC (2020) Moderate exercise modulates tumor metabolism of triple-negative breast cancer. Cells 9:E628.	LEAK OXPHOS ET	N ROX	Permeabilized cells	Mouse	Endothelial;epithelial;mesothelial cell
Ferreira 2020 PLoS Genet	2020	Ferreira N, Andoniou CE, Perks KL, Ermer JA, Rudler DL, Rossetti G, Periyakaruppiah A, Wong JKY, Rackham O, Noakes PG, Degli-Esposti MA, Filipovska A (2020) Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease. PLoS Genet 16:e1008604.	LEAK OXPHOS ET	N ROX	Isolated mitochondria	Mouse	Liver
Jayakumari 2020 J Diabetes	2020	Jayakumari NR, Rajendran RS, Sivasailam A, Vimala SS, Nanda S, Manjunatha S, Pillai VV, Karunakaran J, Gopala S (2020) Impaired substrate-mediated cardiac mitochondrial complex I respiration with unaltered regulation of fatty acid metabolism and oxidative stress status in type 2 diabetic Asian Indians. J Diabetes 12:542-55.	LEAK OXPHOS ET	F N S NS ROX	Isolated mitochondria	Human	Heart
Xia 2020 Biomed Res Int	2020	Xia W, Wang Q, Lu Y, Hu Y, Zhang X, Zhang J, Liu D, Song J, Zhu Z, Liu D, Zhang H (2020) Transient receptor potential channel canonical type 3 deficiency antagonizes myofibroblast transdifferentiation in vivo. Biomed Res Int 2020:1202189.	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Fibroblast
Zhang 2020 Chemosphere	2020	Zhang Y, Li Y, Feng Q, Shao M, Yuan F, Liu F (2020) Polydatin attenuates cadmium-induced oxidative stress via stimulating SOD activity and regulating mitochondrial function in Musca domestica larvae. Chemosphere 248:126009.	LEAK OXPHOS	N S ROX	Isolated mitochondria	Hexapods
Roy Chowdhury 2020 Cancers (Basel)	2020	Roy Chowdhury S, Bouchard EDJ, Saleh R, Nugent Z, Peltier C, Mejia E, Hou S, McFall C, Squires M, Hewitt D, Davidson L, Shen GX, Johnston JB, Doucette C, Hatch GM, Fernyhough P, Marshall A, Gibson SB, Dawe DE, Banerji V (2020) Mitochondrial respiration correlates with prognostic markers in chronic lymphocytic leukemia and is normalized by ibrutinib treatment. Cancers (Basel) 12:E650.	LEAK ET ROUTINE	ROX	Intact cells	Human	Lymphocyte Blood cells
Gruenig 2020 Biochem Pharmacol	2020	Grünig D, Szabo L, Marbet M, Krähenbühl S (2020) Valproic acid affects fatty acid and triglyceride metabolism in HepaRG cells exposed to fatty acids by different mechanisms. Biochem Pharmacol 177:113860.	LEAK OXPHOS ET	N S DQ CIV ROX	Isolated mitochondria	Mouse	Liver
Coppin 2020 Cell Death Dis	2020	Coppin L, Jannin A, Ait Yahya E, Thuillier C, Villenet C, Tardivel M, Bongiovanni A, Gaston C, de Beco S, Barois N, van Seuningen I, Durand E, Bonnefond A, Vienne JC, Vamecq J, Figeac M, Vincent A, Delacour D, Porchet N, Pigny P (2020) Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface. Cell Death Dis 11:360.	LEAK ROUTINE OXPHOS ET	N S Gp CIV NS ROX	Permeabilized cells Intact cells	Human	Islet cell;pancreas;thymus Endothelial;epithelial;mesothelial cell
Yurre 2020 Arq Bras Cardiol	2020	Yurre AR, Silva JDFD, Torres MKDS, Martins EL, Ramos IP, Silva WSFLD, Sarpa JDS, Guedes CCDS, Napoleão TH, Coelho LCBB, Paiva PMG, Medei E (2020) Evaluation of the cardiac effects of a water-soluble lectin (Wsmol) from Moringa oleifera seeds. Arq Bras Cardiol 114:1029-37.	LEAK OXPHOS	N NS ROX	Isolated mitochondria	Mouse	Heart
Baggio 2020 Neurotoxicology	2020	Baggio S, Zenki K, Martins Silva A, Dos Santos TG, Rech G, Lazzarotto G, Dias RD, Mussulini BH, Rico EP, de Oliveira DL (2020) Fetal alcohol spectrum disorders model alters the functionality of glutamatergic neurotransmission in adult zebrafish. Neurotoxicology 78:152-160.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Zebrafish	Nervous system
Tichanek 2020 Sci Rep	2020	Tichanek F, Salomova M, Jedlicka J, Kuncova J, Pitule P, Macanova T, Petrankova Z, Tuma Z, Cendelin J (2020) Hippocampal mitochondrial dysfunction and psychiatric-relevant behavioral deficits in spinocerebellar ataxia 1 mouse model. Sci Rep 10:5418.	LEAK OXPHOS ET	N S CIV NS ROX	Homogenate	Mouse	Nervous system
... further results

Abstracts: Residual oxygen consumption

Sort in ascending/descending order by a click on one of the small symbols in squares below.

	Year	Reference	Coupling	Pathway	Preparation	Organism	Tissue;cell
Cecatto 2022 EBEC	2022	Cecatto C, Cardoso LHD, Gnaiger E (2022) Mitochondrial calcium uptake capacity is lower than calcium retention capacity in the presence and absence of cyclosporin A. EBEC 2022.	LEAK OXPHOS ET	N S NS ROX	Isolated mitochondria	Mouse	Liver
Porter 2022 Abstract Bioblast	2022	6.3. «10+5» Karavyraki M, Gnaiger E, Porter Richard K (2022) A comparison of bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »MitoFit Preprint«	LEAK ROUTINE ET	S ROX	Permeabilized cells	Human
Molina 2022 Abstract Bioblast	2022	3.2. «10+5» Heimler SR, Phang HJ, Bergstrom J, Mahapatra G, Dozier S, Gnaiger E, Molina Anthony JA (2022) Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older women. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »Bioenergetics Communications«	OXPHOS ET	F N S Gp ROX	Permeabilized cells	Human	Blood cells
Cardoso 2022 Abstract Bioblast	2022	4.3. «10+5» Cardoso Luiza HD, Doerrier C, Donnelly C, Komlódi T, Gnaiger E (2022) Redox monitoring and respiration - a new horizon with the NextGen-O2k. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	LEAK OXPHOS ET	N S NS ROX	Permeabilized cells Isolated mitochondria	Mouse	Liver HEK
Irving 2022 Abstract Bioblast	2022	7.4. «5 min» Irving Brian A, Stampley J, Quiriarte H, Wigger Z, Stephens J, Soto P, Allerton TA (2022) Impact of nitric oxide promotors on mitochondrial bioenergetics in a murine model of Alzheimer's disease. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	LEAK OXPHOS ET	N Gp NS ROX	Permeabilized tissue Homogenate	Mouse	Nervous system
Magri 2022 Abstract Bioblast	2022	8.5. «5 min» Magrì Andrea, Cubisino SAM, De Pinto V, Messina A (2022) Modulation of mitochondrial respiration in ALS cells by hexokinase-based peptides: a novel therapeutic approach to fight neurodegeneration. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001	LEAK ROUTINE OXPHOS ET	N S NS ROX	Permeabilized cells Intact cells	Human	Nervous system
Gnaiger 2022 ESCI Bari	2022	Gnaiger E (2022) Bioenergetic cluster analysis – diagnostic evaluation of mitochondrial respiratory control in human fibroblasts. 56^th Annual Scientific Meeting of the European Society for Clinical Investigation.	LEAK ROUTINE ET	ROX	Intact cells	Human	Fibroblast
Doerrier 2020 PaduaMuscleDays Poster	2020	Doerrier C, Gama-Perez P, Chabi B, Ost M, Distefano G, Pesta D, Dahdah N, Lemieux H, Holody C, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Calabria E, Casado M, Fernandez-Ortiz M, Acuna-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wuest R, Dayanidhi S, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen PM, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Commitment to reproducibility in mitochondrial respiration studies with permeabilized muscle fibers. PaduaMuscleDays.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human Mouse	Skeletal muscle
Betiu 2019 MiP2019	2019	Cell-permeable succinate improves amiodarone-induced mitochondrial Complex I and II inhibition in human platelets.	LEAK ET	ROX	Permeabilized cells Intact cells	Human	Platelet
Bastos Sant'Anna Silva 2019 Life Sciences Meeting 2019 Innsbruck AT	2019	Cellular succinate transport and mitochondrial respiratory function in prostate cancer.	ROUTINE	S ROX	Intact cells	Human	Genital
Van der Ende 2019 MiPschool Coimbra	2019	Mitochondrial respiration in muscle tissue of colon cancer patients.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Goncalves Debora 2019 MiPschool Coimbra	2019	Aging effects on mitochondrial control factors in Pink1 knockout Drosophila melanogaster.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Drosophila
Garcia-Roves 2019 MiPschool Coimbra	2019	Generating reference values on mitochondrial respiration in permeabilized muscle fibers.	LEAK OXPHOS ET	N S CIV NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Timohhina 2019 MiP2019	2019	Metabolic effects of mitochondria-targeted antioxidant peptides in colorectal cancer cells.	LEAK OXPHOS ET	ROX		Human	Endothelial;epithelial;mesothelial cell
Lelcu 2019 MiP2019	2019	Assessment of platelet respiration in blood malignancies: a pilot study in children and adults.	LEAK OXPHOS ET	N NS ROX	Permeabilized cells	Human	Platelet
Dominguez-Amorocho 2019 MiP2019	2019	Role of Sirtuin 1/3 in CD4⁺ T cells activation and differentiation in obese and transplanted animals.	LEAK ET OXPHOS	ROX		Mouse	Lymphocyte
Kramer 2019 Abstract IOC141	2019	Kramer P, Distefano G, Monte J, Mills A, Edmunds L, Jurczak M, Cummings SR, Kritchevsky S, Newman AB, Hepple RT, Goodpaster B, Coen PM, Molina A (2019) The Study of Muscle, Mobility, and Aging (SOMMA): A multi-institutional respirometry study. Mitochondr Physiol Network 24.02.	LEAK OXPHOS ET	N CIV NS ROX		Human	Skeletal muscle
Chabi 2019 MiP2019	2019	Generating reference values on mitochondrial respiration in permeabilized muscle fibers.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Doerrier 2019 MiP2019	2019	Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers.	LEAK ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Cardoso 2019 MiP2019	2019	Effects of glucose concentration in cell culture media on hepatocellular carcinoma HuH7 cells evaluated by high-resolution respirometry.	LEAK ROUTINE ET	ROX	Intact cells	Human	Liver
Sumbalova 2019a MiP2019	2019	Platelet mitochondrial function, coenzyme Q₁₀, and oxidative stress in patients with chronic kidney diseases.	LEAK OXPHOS	F N S Gp CIV NS ROX	Intact cells	Human	Platelet
Sumbalova 2019b MiP2019	2019	The decline of mitochondrial respiration in isolated platelets after short-term storage.	LEAK OXPHOS	F N S Gp CIV NS ROX	Intact cells	Human	Platelet
Bastos Sant'Anna Silva 2018 MiPschool Tromso C4	2018	Role of succinate in prostate cancer cells: uptake and mitochondrial respiratory function.	LEAK ROUTINE OXPHOS ET	S ROX	Intact cells	Human	Genital
Schoepf 2018 33rd Annual EAU Congress Copenhagen	2018	Shift of mitochondrial oxidative phosphorylation is associated with mtDNA mutational load in primary prostate cancer tissue.	LEAK OXPHOS ET	F N NS Other combinations ROX	Permeabilized cells Permeabilized tissue	Human	Genital
Chang 2018 Life Sciences Meeting 2018 Innsbruck AT	2018	pH dependence of mitochondrial respiration and H₂O₂ production in oral cancer cells – a pilot study.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Permeabilized cells	Human	HEK Kidney
Doerrier 2018 ESCI2018	2018	High-resolution respirometry, two techniques combined in one to explore mitochondrial function in health and disease	LEAK ROUTINE OXPHOS ET	F N S Gp ROX CIV	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria	Human Mouse	Heart Skeletal muscle Nervous system Blood cells HEK
Doerrier 2018 EBEC2018	2018	Respiratory mapping of mitochondrial pathways for establishing a database of mitochondrial physiology.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Permeabilized cells Homogenate Isolated mitochondria	Human Mouse	Heart Nervous system Blood cells HEK Platelet
Bastos Sant'Anna Silva 2018 TRANSMIT Bertinoro di Romagna IT	2018	Cellular succinate transport and mitochondrial respiratory function in prostate cancer.	ROUTINE LEAK OXPHOS ET	S ROX	Permeabilized cells Intact cells	Human	HEK Genital
Doerrier 2018 MiP2018a	2018	Inter-laboratory harmonization of protocols for mitochondrial function evaluation in permeabilized muscle fibers.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Garcia-Roves 2018 MiP2018b	2018	Generating mitochondrial respirometry reference values from permeabilized mouse soleus muscle fibers. Working Group 2 report. Garcia-Roves_Presentation	OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Krajcova 2018 ICO134	2018	Skeletal muscle bioenergetics in critically ill patients: effect of early rehabilitation on mitochondrial functions and insulin resistance during and 6 months after critical illness.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Human	Skeletal muscle
Doerrier 2018 MiP2018c	2018	Inter-laboratory study on human permeabilized myofibers: effects of fiber preparation, respiration buffer, and blebbistatin on mitochondrial respiratory capacity and oxygen limitation.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue	Human	Skeletal muscle
Garipi 2018 MiPschool Tromso E2	2018	Phenotyping mitochondrial metabolism in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence: respiratory capacity, extracelular proton flux and ROS production	LEAK ROUTINE OXPHOS ET	CIV NS ROX	Permeabilized cells Permeabilized tissue	Human	Endothelial;epithelial;mesothelial cell Other cell lines
Krajcova 2018 MiPschool Tromso E2	2018	High-resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle.	LEAK OXPHOS ET	N NS ROX	Homogenate	Human	Heart
Hoel 2017 MiPschool Obergurgl	2017	A study on mitochondrial stress responses due to OXPHOS inhibition.	LEAK	ROX		Human	Nervous system
Gasparrini 2017 MiPschool Obergurgl	2017	Anti-inflammatory effects of strawberry and honey extracts in RAW 264.7 macrophages stressed with LPS.	LEAK	ROX		Mouse	Macrophage-derived
Giampieri 2017 MiPschool Obergurgl	2017	Strawberry extract protects human dermal fibroblasts against oxidative stress and improves mitochondrial functionality.	LEAK	ROX			Fibroblast
Afrin 2017 MiPschool Obergurgl	2017	Induction of mitochondrial dysfunction by Manuka honey as a strategy for prevention of colon cancer in vitro model: a rising role on reactive oxygen species, apoptosis, and cell metabolism.	LEAK	ROX
Bento 2017 MITOEAGLE Obergurgl	2017	Isolation of human urine-derived stem cells for mitochondrial function profile assessment.	LEAK ET	ROX	Intact cells	Human	Stem cells
Gnaiger 2017 MiPschool A1	2017	Elemental steps towards understanding mitochondrial core energy metabolism: coupling control.	LEAK ROUTINE OXPHOS ET	ROX	Intact cells Permeabilized cells Permeabilized tissue Isolated mitochondria
Gnaiger 2017 MiPschool A4	2017	Respiratory pathway control in mitochondrial core energy metabolism: from bioenergetics to mitochondrial physiology.		F N S Gp CIV NS Other combinations ROX	Permeabilized cells Permeabilized tissue Isolated mitochondria
Gnaiger 2017 MiPschool C1	2017	Apparent Complex IV excess capacity and biochemical thresholds.		N S CIV NS ROX	Permeabilized cells Permeabilized tissue Isolated mitochondria
Labieniec-Watala 2017 MiP2017	2017	Lack of the effect of low metformin concentrations on the response of breast cancer cell mitochondria to radiotherapy under conditions of the in vitro experimental hyperglycemia. Labieniec-Watala_Presentation	OXPHOS ET	N S NS ROX	Permeabilized cells	Human	Genital
Garcia-Roves 2017 MiP2017	2017	Mitochondrial respirometry reference values from permeabilized mouse soleus muscle fibers. MitoEAGLE WG2 pilot study. Garcia-Roves_Presentation	OXPHOS ET	N S NS ROX	Permeabilized tissue	Mouse	Skeletal muscle
Markova 2017 MiP2017	2017	Porcine sepsis and associated myocardial depression.	LEAK OXPHOS	N S CIV NS ROX		Pig	Heart
Michalak 2017 MiP2017	2017	The effect of anticoagulants on mitochondrial respiration in intact peripheral blood mononuclear cells.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Rybacka-Mossakowska 2017 MiP2017	2017	Mitochondrial respiration in intact peripheral blood mononuclear cells in multiple sclerosis patients.	LEAK ROUTINE ET	ROX	Intact cells	Human	Blood cells
Irving 2017 MiP2017	2017	Impact of acute exercise on PBMC respiratory function and methodological considerations.	LEAK ROUTINE OXPHOS ET	N NS ROX			Blood cells
Chowdhury 2017 Blood	2017	Importance of mitochondrial metabolism as a selective therapeutic approach in chronic lymphocytic leukemia patients.	LEAK	ROX	Intact cells	Human	Lymphocyte
Reboredo-Rodriguez 2017 MiPschool Obergurgl	2017	Protective effect of a polyphenol-rich strawberry extract on oxidative and endoplasmic reticulum stresses in HepG2 cell line.	LEAK ET	ROX		Human	Liver
Komlodi 2017 MiPschool Obergurgl	2017	Electron pressure exerted by convergent succinate- and glycerophosphate-pathways to the Q-junction regulate reversed electron transfer to Complex I and H₂O₂ production.	LEAK OXPHOS	N S Gp Other combinations ROX	Isolated mitochondria	Mouse	Nervous system
Karavyraki 2017 MiPschool Obergurgl	2017	Mitochondrial function and morphology linked to metabolic differences in normal, dysplastic and cancerous oral cells.	LEAK	ROX	Intact cells	Human
Garcia-Souza 2017 MiPschool Obergurgl	2017	Assessment of mitochondrial respiratory function in cryopreserved platelets.	ROUTINE ET	S CIV ROX	Intact cells Permeabilized cells	Human	Blood cells Platelet
Nogueras 2017 MiPschool Obergurgl	2017	Mitochondrial dysfunction in peripheral blood mononuclear cells from multiple sclerosis patients.	LEAK ROUTINE ET	ROX	Intact cells		Blood cells
Markova 2017 MiPschool Obergurgl	2017	Mitochondrial respiration in the rat left heart ventricle after inhibition of pyruvate dehydrogenase kinase.	LEAK OXPHOS	N S CIV NS ROX	Homogenate	Rat	Heart
Collins 2017 MiPschool Obergurgl	2017	The effects of a Mediterranean versus Western diet on nonhuman primate skeletal muscle bioenergetics.	OXPHOS	F N S Gp CIV NS ROX	Intact cells
Michalak 2017 Abstract MITOEAGLE Barcelona	2017	Mitochonrial respiration in intact peripheral blood mononuclear cells in patients with extrapyramidal syndromes.	LEAK ROUTINE OXPHOS ET	ROX	Intact cells	Human	Blood cells
Sobotka 2017 Abstract MITOEAGLE Barcelona	2017	The effect of 24 weeks of high-fat and high-cholesterol diet on rat liver mitochondria. Sobotka_Presentation	OXPHOS ET	F N S Gp ROX	Isolated mitochondria	Rat	Liver
Sumbalova 2016b Abstract MitoFit Science Camp 2016	2016	Human blood cells: isolation and HRR.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Permeabilized cells Intact cells	Human	Blood cells Lymphocyte Platelet
Hoppel 2016c Abstract MitoFit Science Camp 2016	2016	Mitochondrial respiration in permeabilized skin fibroblasts.	OXPHOS ET	N S CIV NS ROX	Permeabilized cells	Human	Endothelial;epithelial;mesothelial cell Fibroblast
Krumschnabel 2016b Abstract MitoFit Science Camp 2016	2016	O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry.	LEAK OXPHOS ET	N S NS ROX		Human	Kidney HEK
Bezuidenhout 2016b Abstract MitoFit Science Camp 2016	2016	Analysis and comparison of mitochondrial function using cooling plate or ice during mechanical separation of mouse skeletal muscle fibers.	LEAK OXPHOS ET	N S ROX	Permeabilized tissue	Mouse	Skeletal muscle
Lamberti 2016 Abstract MitoFit Science Camp 2016	2016	Development of a reference sample for HRR.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS Other combinations ROX		Human	Kidney HEK
Krumschnabel 2016a Abstract MitoFit Science Camp 2016	2016	O2k-Protocols: Mitochondrial preparations for HRR.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Homogenate Isolated mitochondria	Mouse	Heart
Doerrier 2016 Abstract MitoFit Science Camp 2016	2016	Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV NS ROX	Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria	Human Mouse	Heart Blood cells HEK Platelet
Laner 2016 Abstract MitoFit Science Camp 2016	2016	OXPHOS and ET-capacity in permeabilized fibers of canine superathletes. Analysis of HRR data presenting unexpected challenges.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Dog	Skeletal muscle
Sobotka 2016 Abstract IOC116	2016	Sobotka O, Kucera Otto, Stankova P, Endlicher R, Nozickova K, Banni A, Cervinkova Z (2016) Mitochondrial respiration in fatty liver. Mitochondr Physiol Network 21.11	LEAK OXPHOS ET	F N S Gp CIV NS Other combinations ROX	Isolated mitochondria	Rat	Liver
Sumbalova 2016 Abstract Mito Xmas Meeting Innsbruck	2016	Methods for evaluation of mitochondrial membrane potential with multi-sensor high-resolution respirometry: potentiometry vs fluorometry.	LEAK OXPHOS ET	F N S NS ROX		Mouse	Nervous system
Laner 2016 Abstract Mito Xmas Meeting Innsbruck	2016	OXPHOS and ET capacity in permeabilized fibers of canine superathletes.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Dog	Skeletal muscle
Doerrier 2016b Abstract Mito Xmas Meeting Innsbruck	2016	Searching for specific targets of ischemic damage of cardiac mitochondria using O2k-Fluorometry.	LEAK OXPHOS ET	F N S Gp CIV ROX	Isolated mitochondria	Mouse	Heart
Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human Mouse	Skeletal muscle
Van Dyk 2015 Abstract MiPschool Cape Town 2015	2015	Optimization of selected cell lines for use on the Seahorse extracellular flux analyzer.	LEAK ROUTINE ET	N ROX	Isolated mitochondria	Human	Other cell lines Fibroblast
Gnaiger 2015 Abstract MiPschool Cape Town 2015 II	2015	On coupling control of mitochondrial respiration. What is wrong with the RCR?	LEAK ROUTINE OXPHOS ET	N S ROX
Dyrstad 2015 Abstract MiPschool London 2015	2015	Activation of epithelial to mesenchymal transition (EMT) regulates stemness and metabolic reprogramming in mammary epithelial cells.	LEAK ROUTINE ET	N ROX		Human	Endothelial;epithelial;mesothelial cell Other cell lines
Blecha 2015 Abstract MiP2015	2015	Modulation of mitochondrial electron transport chain activity differentially regulates cell death in proliferating and quiescent cells.	LEAK ET	ROX
Calzia 2015 Abstract MiP2015	2015	Mitochondrial respiration in homogenized small tissue biopsies from the M. Vastus lateralis of patients with Huntington's Disease before and after cycling exercise.	LEAK OXPHOS ET	N S ROX		Human	Skeletal muscle
Karabatsiakis 2015 Abstract MiP2015	2015	Mitochondrial respiration of peripheral blood mononuclear cells in patients with borderline personality disorder.	LEAK ROUTINE OXPHOS ET	ROX		Human	Blood cells
Rohlena 2015 Abstract MiP2015	2015	Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation.	ROUTINE OXPHOS ET	S ROX	Permeabilized cells Isolated mitochondria	Human	Other cell lines
Galina 2015 Abstract MiP2015	2015	High intensity interval training (HIIT) induces specific changes in respiration and electron leakage in the mitochondria of different rat skeletal muscles.	LEAK	N S ROX	Permeabilized tissue	Rat	Skeletal muscle
Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	OXPHOS ET	F N S NS ROX	Permeabilized tissue	Rat	Heart
Chou 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	2015	Chou 2015 Fatty Acid Oxidation O2k-Network Discussion Forum	OXPHOS ET	F N S NS ROX	Permeabilized cells Permeabilized tissue		Blood cells Lymphocyte Platelet
Laner 2015 Abstract MiP2015	2015	Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibers of canine superathletes.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Dog	Skeletal muscle
Doerrier 2014 Abstract SECF	2014	Evaluation of melatonin treatment in mitochondria of permeabilized myocardial fibers from septic mice.	LEAK OXPHOS ET	N S NS ROX	Permeabilized tissue Isolated mitochondria	Mouse	Heart
Felser 2014 Abstract MiP2014	2014	Assessing mitochondrial dysfunction in fibroblast cells – a comparison between O2k and multiwell respirometry.	ROUTINE ET	ROX	Intact cells	Human	Endothelial;epithelial;mesothelial cell HeLa Fibroblast
Votion 2013 Abstract MiP2013	2013	Votion DM, Mouithys-Mickalad A, Ceusters Justine D, Lemieux H, Tosi I, Franck T, Art T, Niesten A, Serteyn D (2013) The challenge of understanding myopathies in horses using permeabilized muscle cells. Mitochondr Physiol Network 18.08.	OXPHOS ET	F N S NS ROX	Permeabilized tissue	Horse	Skeletal muscle
Amoedo 2013 Abstract MiP2013	2013	Amoêdo ND, Rodrigues MF, Pereira S, Melo F, Jasiulionis M, Galina A, Rumjanek FD(2013) Comparative biochemistry of tumorigenesis: role of mitochondria in the metastatic process. Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS ET	N S ROX	Permeabilized cells Enzyme Intact cells	Mouse	Endothelial;epithelial;mesothelial cell Other cell lines
Jezek 2013 Abstract MiP2013	2013	Ježek P, Ježek J, Zelenka J, Dlasková A, Jabůrek M (2013) Antioxidant synergy of mitochondrial uncoupling protein UCP2 and phospholipase iPLA2γ. Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS ET	N S ROX	Isolated mitochondria Intact cells	Mouse	Lung;gill Islet cell;pancreas;thymus
Christen 2013 Abstract MiP2013	2013	Christen F, Desrosiers V, Blier PU (2013) Thermal sensitivity of mitochondria from arctic charr heart: Mitochondrial respiration and ROS production. Mitochondr Physiol Network 18.08.	OXPHOS ET	N S CIV NS ROX	Isolated mitochondria	Other mammals Fishes	Heart
Larsen FJ 2013 Abstract MiP2013	2013	Larsen FJ, Schiffer TA, Lundberg JO, Weitzberg E (2013) Human mitochondria has a unique response to ischemia-reperfusion injury compared to mitochondria from rat, mouse and pig . Mitochondr Physiol Network 18.08.	OXPHOS	ROX	Isolated mitochondria	Human Pig Mouse Rat
Oliveira MF 2013 Abstract MiP2013	2013	Oliveira MF (2013) Comparative mitochondrial physiology in blood feeding insect vectors and parasites. Mitochondr Physiol Network 18.08.	LEAK ROUTINE OXPHOS ET	F N S Gp CIV ROX	Intact organism Intact organ Permeabilized cells Permeabilized tissue Homogenate Intact cells	Human Drosophila Hexapods Other invertebrates	Skeletal muscle Neuroblastoma
Pichaud 2013 Abstract MiP2013	2013	Pichaud N, Blier PU(2013) Importance of mitochondrial haplotypes in the expression of metabolic phenotypes under different conditions. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N S Gp CIV NS ROX	Permeabilized tissue	Drosophila Hexapods	Skeletal muscle
Rodrigues 2013 Abstract MiP2013	2013	Rodrigues MF, Amoedo ND, Rumjanek FD (2013) Studies of bioenergetics alterations in breast cancer lines induced by histone desacetylase inhibitors. Mitochondr Physiol Network 18.08.	LEAK ROUTINE ET	ROX	Intact cells		Genital
Slinde 2013 Abstract MiP2013	2013	Slinde E, Egelandsdal B, Olsen RE (2013) Respiration of tissue and mitochondria from Atlantic salmon (Salmo salar, L) liver, muscle, heart, brain and blood. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N ROX	Permeabilized tissue Isolated mitochondria	Other mammals Fishes	Heart Liver Blood cells
Szibor 2013 Abstract MiP2013	2013	Szibor M, Heidler J, Gizatullina Z, Salwig I, Dhandapani PK, Wittig I, Rustin P (2013) Expression of Ciona intestinalis alternative oxidase in mouse. Mitochondr Physiol Network 18.08.	LEAK OXPHOS	ROX	Isolated mitochondria Oxidase;biochemical oxidation	Mouse	Heart Skeletal muscle Nervous system Liver Lung;gill
Cavalcanti de Albuquerque 2013 Abstract MiP2013	2013	Cavalcanti de Albuquerque JP, Salvador IC, Martins EG, Jardim-Messeder D; Werneck de Castro JPS; Carvalho DP; Galina A (2013) Skeletal muscle mitochondrial function in ovariectomized rats: A time course study and the role of estrogen replacement. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	F N S Gp NS ROX	Intact organism Permeabilized tissue	Rat	Skeletal muscle
Krumschnabel 2013 Abstract MiP2013	2013	Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N S NS ROX	Homogenate	Mouse Fishes	Heart Nervous system Liver
Pecina 2013 Abstract MiP2013	2013	Pecina P, Houšťková H, Mráček T, Pecinová A, Nůsková H, Tesařová M, Hansíková H, Janota J, Zeman J, Houštěk J (2013) The use of lymphocytes for diagnostics of mitochondrial oxidative phosphorylation disorders. Mitochondr Physiol Network 18.08.	LEAK OXPHOS ET	N S Gp NS Other combinations ROX	Permeabilized cells Homogenate	Human	Blood cells Lymphocyte
Watala 2012 Abstract Bioblast	2012	Watala C, Przygodzki T, Siewiera K, Kassassir H, Talar M, Labieniec-Watala M (2012) Oxygen consumption in resting and activated blood platelets: platelet mitochondria and cyclooxygenases as compounding targets for high-resolution respirometry. Mitochondr Physiol Network 17.12.	ROUTINE ET	NS ROX	Isolated mitochondria Enzyme Intact cells	Human Rat	Endothelial;epithelial;mesothelial cell Blood cells Platelet
Pesta 2011Abstract Mitochondrial Medicine-Training	2011	Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibers. Abstract Mitochondrial Medicine Chicago.	LEAK OXPHOS ET	F N S NS ROX	Permeabilized tissue	Human	Skeletal muscle

MitoPedia concepts: Respiratory state, Recommended

MitoPedia topics: EAGLE

Labels: MiParea: Respiration

Pathway: ROX HRR: Theory