E-L net ET capacity: Difference between revisions
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|abbr=''≈E'' | |abbr=''≈E'' | ||
|description=[[Image:E-L.jpg|50 px|Free ET-capacity]] The '''Free ET-capacity''', ''≈E'', is the [[ET capacity]] corrected for [[LEAK respiration]], ''≈E'' = ''E-L''. ''≈E'' is the respiratory capacity potentially available for ion transport and phosphorylation of ADP to ATP. Oxygen consumption in the ET-pathway state, therefore, is partitioned into the free ET capacity, ''≈E'', and LEAK respiration, ''L<sub>P</sub>'', compensating for proton leaks, slip and cation cycling: ''E'' = ''≈E''+''L<sub>P</sub>'' (see [[free OXPHOS capacity]]). | |description=[[Image:E-L.jpg|50 px|Free ET-capacity]] The '''Free ET-capacity''', ''≈E'', is the [[ET-capacity]] corrected for [[LEAK respiration]], ''≈E'' = ''E-L''. ''≈E'' is the respiratory capacity potentially available for ion transport and phosphorylation of ADP to ATP. Oxygen consumption in the ET-pathway state, therefore, is partitioned into the free ET-capacity, ''≈E'', and LEAK respiration, ''L<sub>P</sub>'', compensating for proton leaks, slip and cation cycling: ''E'' = ''≈E''+''L<sub>P</sub>'' (see [[free OXPHOS capacity]]). | ||
|info=[[Gnaiger 2014 MitoPathways]] | |info=[[Gnaiger 2014 MitoPathways]] | ||
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== Coupling control states for ''≈E'' == | == Coupling control states for ''≈E'' == | ||
::» [[Respiratory state]] | ::» [[Respiratory state]] | ||
* [[Reference state]], ''Z<sub>X</sub>'': [[Image:E.jpg|link=ET capacity|ET capacity]] [[ET capacity]] | * [[Reference state]], ''Z<sub>X</sub>'': [[Image:E.jpg|link=ET-capacity|ET-capacity]] [[ET-capacity]]; ''E'' = ''E´''-''Rox'' | ||
* [[Background state]], ''Y<sub>X</sub>'': [[Image:L.jpg|link=LEAK respiration|LEAK]] [[LEAK respiration]] | * [[Background state]], ''Y<sub>X</sub>'': [[Image:L.jpg|link=LEAK respiration|LEAK]] [[LEAK respiration]]; ''L'' = ''L´''-''Rox'' | ||
* [[Metabolic control variable]], ''X=Z<sub>X</sub>-Y<sub>X</sub>'': [[Image:E-L.jpg|50 px|link=Free ET-capacity |Free ET-capacity]] Scope of uncoupler stimulation, [[Free ET-capacity]] | * [[Metabolic control variable]], ''X=Z<sub>X</sub>-Y<sub>X</sub>'': [[Image:E-L.jpg|50 px|link=Free ET-capacity |Free ET-capacity]] Scope of uncoupler stimulation, [[Free ET-capacity]]; ''≈E'' = ''E-L'' | ||
Revision as of 23:21, 4 January 2018
- high-resolution terminology - matching measurements at high-resolution
E-L net ET capacity
Description
The Free ET-capacity, ≈E, is the ET-capacity corrected for LEAK respiration, ≈E = E-L. ≈E is the respiratory capacity potentially available for ion transport and phosphorylation of ADP to ATP. Oxygen consumption in the ET-pathway state, therefore, is partitioned into the free ET-capacity, ≈E, and LEAK respiration, LP, compensating for proton leaks, slip and cation cycling: E = ≈E+LP (see free OXPHOS capacity).
Abbreviation: ≈E
Reference: Gnaiger 2014 MitoPathways
MitoPedia concepts:
Respiratory state,
Recommended
MitoPedia topics:
EAGLE
Communicated by Gnaiger E 2014-09-21, edited 2015-01-19.
The Blue Book 2014: Fig. 2.4.
Coupling control states for ≈E
- Reference state, ZX:
ET-capacity; E = E´-Rox - Background state, YX:
LEAK respiration; L = L´-Rox - Metabolic control variable, X=ZX-YX:
Scope of uncoupler stimulation, Free ET-capacity; ≈E = E-L
Flux control factor
- » Flux control factor, FCF
- Coupling control factor, 1-YX/ZX:
E-L coupling control factor, ET-pathway coupling efficiency: j≈E = ≈E/E =(E-L)/E = 1-L/E
Compare
- mt-Preparations
Free OXPHOS capacity, ≈P = P-L - Intact cells
Free ROUTINE activity, ≈R = R-L
