Difference between revisions of "Elamipretide"
From Bioblast
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|info=[[Chatfield 2019 JACC Basic Transl Sci]] | |info=[[Chatfield 2019 JACC Basic Transl Sci]] | ||
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== Elamipretide and mitObesity == | == Elamipretide and mitObesity == | ||
''Work in progress'' by [[Gnaiger E]] 2020-02-10 linked to a preprint in preparation on [[body mass excess |'''BME''']] and [[:Category:BME and mitObesity |'''mitObesity''']]. | |||
== References: Bendavia (Elamipretide) == | |||
::::# Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL (2019) Elamipretide improves mitochondrial function in the failing human heart. JACC Basic Transl Sci 4:147-57. - [[Chatfield 2019 JACC Basic Transl Sci |»Bioblast link«]] | ::::# Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL (2019) Elamipretide improves mitochondrial function in the failing human heart. JACC Basic Transl Sci 4:147-57. - [[Chatfield 2019 JACC Basic Transl Sci |»Bioblast link«]] | ||
::::# Brown DA, Hale SL, Baines CP, del Rio CL, Hamlin RL, Yueyama Y, Kijtawornrat A, Yeh ST, Frasier CR, Stewart LM, Moukdar F, Shaikh SR, Fisher-Wellman KH, Neufer PD, Kloner RA (2014) Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia. J Cardiovasc Pharmacol Ther 19:121-32. - [[Brown 2014 J Cardiovasc Pharmacol Ther |»Bioblast link«]] | ::::# Brown DA, Hale SL, Baines CP, del Rio CL, Hamlin RL, Yueyama Y, Kijtawornrat A, Yeh ST, Frasier CR, Stewart LM, Moukdar F, Shaikh SR, Fisher-Wellman KH, Neufer PD, Kloner RA (2014) Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia. J Cardiovasc Pharmacol Ther 19:121-32. - [[Brown 2014 J Cardiovasc Pharmacol Ther |»Bioblast link«]] | ||
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::::# https://www.ncbi.nlm.nih.gov/pubmed/29500292 | ::::# https://www.ncbi.nlm.nih.gov/pubmed/29500292 | ||
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Revision as of 00:10, 10 February 2020
Description
Bendavia (Elamipretide) was developed as a mitochondria-targeted drug against degenerative diseases, including cardiac ischemia-reperfusion injury. Clinical trials showed variable results. It is a cationic tetrapeptide which readily passes cell membranes, associates with cardiolipin in the mitochondrial inner membrane. Supercomplex-associated CIV activity significantly improved in response to elamipretide treatment in the failing human heart.
Abbreviation: Bendavia
Reference: Chatfield 2019 JACC Basic Transl Sci
Elamipretide and mitObesity
Work in progress by Gnaiger E 2020-02-10 linked to a preprint in preparation on BME and mitObesity.
References: Bendavia (Elamipretide)
- Chatfield KC, Sparagna GC, Chau S, Phillips EK, Ambardekar AV, Aftab M, Mitchell MB, Sucharov CC, Miyamoto SD, Stauffer BL (2019) Elamipretide improves mitochondrial function in the failing human heart. JACC Basic Transl Sci 4:147-57. - »Bioblast link«
- Brown DA, Hale SL, Baines CP, del Rio CL, Hamlin RL, Yueyama Y, Kijtawornrat A, Yeh ST, Frasier CR, Stewart LM, Moukdar F, Shaikh SR, Fisher-Wellman KH, Neufer PD, Kloner RA (2014) Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia. J Cardiovasc Pharmacol Ther 19:121-32. - »Bioblast link«
- Shaikh SR, Moukdar F, Alleman RJ, Lark DS, Neufer PD, Brown D (2014) The cardiolipin-targeting peptide Bendavia improves post-ischemic mitochondrial energetics by sustaining native respiratory protein complexes. Am Heart Assoc 130:A17592. - »Bioblast link«
- Campbell MD, Duan J, Samuelson AT, Gaffrey MJ, Wang L, Bammler TK, Moore RJ, White CC, Kavanagh TJ, Voss JG, Szeto HH, Rabinovitch PS, Qian WJ, Marcinek DJ (2018) Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice. Free Radic Biol Med 134:268-81. - »Bioblast link«
- https://www.ncbi.nlm.nih.gov/pubmed/29500292
MitoPedia: mitObesity drugs
Healthy reference population | Body mass excess | BFE | BME cutoffs | BMI | H | M | VO2max | mitObesity drugs |
MitoPedia concepts:
MiP concept
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MitoPedia:mitObesity drug