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 YearReferenceTissue and cellMammal and model
McKenna 2021 Redox Biol2021McKenna HT, O'Brien KA, Fernandez BO, Minnion M, Tod A, McNally BD, West JA, Griffin JL, Grocott MP, Mythen MG, Feelisch M, Murray AJ, Martin DS (2021) Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness. Redox Biol 41:101907.Skeletal muscleHuman
Larsen 2021 Cell Mol Gastroenterol Hepatol2021Larsen LE, van den Boogert MAW, Rios-Ocampo WA, Jansen JC, Conlon D, Chong PLE, Levels JHM, Eilers RE, Sachdev VV, Zelcer N, Raabe T, He M, Hand NJ, Drenth JPH, Rader DJ, Stroes ESG, Lefeber DJ, Jonker JW, Holleboom AG (2021) Defective lipid droplet - lysosome interaction causes fatty liver disease as evidenced by human mutations in TMEM199 and CCDC115. Cell Mol Gastroenterol Hepatol 13:583-97.LiverHuman
Alves 2021 Eur J Nutr2021Alves BL, Ara煤jo TDR, Guimar茫es DSPSF, Zoppi CC, Figueiredo MS, Carneiro EM (2021) Amino acid restriction alters survival mechanisms in pancreatic beta cells: possible role of the PI3K/Akt pathway. Eur J Nutr 60:3947-57.Islet cell;pancreas;thymusRat
Gvozdjakova 2021 PLoS One2021Gvozdj谩kov谩 A, Sumbalov谩 Z, Kucharsk谩 J, Szamosov谩 M, 膶谩pov谩 L, Rausov谩 Z, Van膷ov谩 O, Mojto V, Langsjoen P, Palacka P (2021) Platelet mitochondrial respiration and coenzyme Q10 could be used as new diagnostic strategy for mitochondrial dysfunction in rheumatoid diseases. PLoS ONE 16:e0256135.PlateletHuman
Scheffer 2021 Brain Commun2021Scheffer DDL, Freitas FC, Aguiar AS Jr, Ward C, Guglielmo LGA, Prediger RD, Cronin SJF, Walz R, Andrews NA, Latini A (2021) Impaired dopamine metabolism is linked to fatigability in mice and fatigue in Parkinson's disease patients. Brain Commun 3:fcab116.Skeletal muscleRat
Sun 2021 J Genet Genomics2021Sun Y, Wei X, Fang F, Shen Y, Wei H, Li J, Ye X, Zhan Y, Ye X, Liu X, Yang W, Li Y, Geng X, Huang X, Ruan Y, Qin Z, Yi S, Lyu J, Fang H, Yu Y (2021) HPDL deficiency causes a neuromuscular disease by impairing the mitochondrial respiration. J Genet Genomics 48:727-36.HeLa
Lymphocyte
Human
Zanou 2021 Nat Commun2021Zanou N, Dridi H, Reiken S, Imamura de Lima T, Donnelly C, De Marchi U, Ferrini M, Vidal J, Sittenfeld L, Feige JN, Garcia-Roves PM, Lopez-Mejia IC, Marks AR, Auwerx J, Kayser B, Place N (2021) Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity. Nat Commun 12:7219.Skeletal muscleMouse
Gratl 2021 J Transl Med2021Gratl A, Pesta D, Gruber L, Speichinger F, Raude B, Omran S, Greiner A, Frese JP (2021) The effect of revascularization on recovery of mitochondrial respiration in peripheral artery disease: a case control study. https://doi.org/10.1186/s12967-021-02908-0JSkeletal muscleHuman
Pesta 2021 Front Endocrinol (Lausanne)2021Pesta D, Jelenik T, Zaharia OP, Bobrov P, G枚rgens S, B贸dis K, Karusheva Y, Krako Jakovljevic N, Lalic NM, Markgraf DF, Burkart V, M眉ssig K, Knebel B, Kotzka J, Eckel J, Strassburger K, Szendroedi J, Roden M (2021) NDUFB6 polymorphism is associated with physical activity-mediated metabolic changes in type 2 diabetes. https://doi.org/10.3389/fendo.2021.693683Skeletal muscleMouse
Wuest 2021 Int J Mol Sci2021W眉st RCI, Coolen BF, Held NM, Daal MRR, Alizadeh Tazehkandi V, Baks-Te Bulte L, Wiersma M, Kuster DWD, Brundel BJJM, van Weeghel M, Strijkers GJ, Houtkooper RH (2021) The antibiotic doxycycline impairs cardiac mitochondrial and contractile function. Int J Mol Sci 22:4100.HeartMouse
Ayer 2021 Redox Biol2021Ayer A, Fazakerley DJ, Suarna C, Maghzal GJ, Sheipouri D, Lee KJ, Bradley MC, Fern谩ndez-Del-Rio L, Tumanov S, Kong SM, van der Veen JN, Yang A, Ho JWK, Clarke SG, James DE, Dawes IW, Vance DE, Clarke CF, Jacobs RL, Stocker R (2021) Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q. Redox Biol 46:102127.Saccharomyces cerevisiae
Liu 2021 Front Physiol2021Liu H, Tenzing N, van Patot MT, Qile M, Ge RL, Wuren T (2021) Enhanced placental mitochondrial respiration in Tibetan women at high altitude. Front Physiol 12:697022. doi: 10.3389/fphys.2021.697022GenitalHuman
Went 2021 Batchelor thesis2021Went N (2021) Oxygen dependence of photosynthesis and light-enhanced dark respiration studied by High-Resolution PhotoRespirometry. Batchelor thesis:26 pp.Plants
Hodges 2021 J Biol Chem2021Hodges WT, Jarasvaraparn C, Ferguson D, Griffett K, Gill LE, Chen Y, Ilagan MXG, Hegazy L, Elgendy B, Cho K, Patti GJ, McCommis KS, Finck BN (2021) Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice. J Biol Chem 298:101554.HeartMouse
Kumar 2021 JCI Insight2021Kumar A, Welch N, Mishra S, Bellar A, Silva RN, Li L, Singh SS, Sharkoff M, Kerr A, Chelluboyina AK, Sekar J, Attaway AH, Hoppel C, Willard B, Davuluri G, Dasarathy S (2021) Metabolic reprogramming during hyperammonemia targets mitochondrial function and postmitotic senescence. JCI Insight 6:e154089.Skeletal muscleMouse
Rat
Galli 2021 Front Physiol2021Galli GLJ, Ruhr IM, Crossley J, Crossley DA 2nd (2021) The long-term effects of developmental hypoxia on cardiac mitochondrial function in snapping turtles. Front Physiol 12:689684. doi: 10.3389/fphys.2021.689684HeartReptiles
Palzur 2021 Int J Mol Sci2021Palzur E, Edelman D, Sakas R, Soustiel JF (2021) Etifoxine restores mitochondrial oxidative phosphorylation and improves cognitive recovery following traumatic brain injury. Int J Mol Sci 22:12881. doi: 10.3390/ijms222312881Nervous systemRat
Komlodi 2021 BEC AmR-O22021Koml贸di T, Sobotka O, Gnaiger E (2021) Facts and artefacts on the oxygen dependence of hydrogen peroxide production using Amplex UltraRed. Bioenerg Commun 2021.4. https://doi.org/10.26124/bec:2021-0004Other cell linesSaccharomyces cerevisiae
Bischof 2021 Sci Transl Med2021Bischof C, Mirtschink P, Yuan T, Wu M, Zhu C, Kaur J, Pham MD, Gonzalez-Gonoggia S, Hammer M, Rogg EM, Sharma R, Bottermann K, Gercken B, Hagag E, Berthonneche C, Sossalla S, Stehr SN, Maxeiner J, Duda MA, Latreille M, Zamboni N, Martelli F, Pedrazzini T, Dimmeler S, Krishnan J (2021) Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease. Sci Transl Med 13:eabi7964.
Avin 2021 Sci Rep2021Avin KG, Hughes MC, Chen NX, Srinivasan S, O'Neill KD, Evan AP, Bacallao RL, Schulte ML, Moorthi RN, Gisch DL, Perry CGR, Moe SM, O'Connell TM (2021) Skeletal muscle metabolic responses to physical activity are muscle type specific in a rat model of chronic kidney disease. Sci Rep 11:9788.Skeletal muscleRat
Theall 2021 Physiol Rep2021Theall B, Stampley J, Cho E, Granger J, Johannsen NM, Irving BA, Spielmann G (2021) Impact of acute exercise on peripheral blood mononuclear cells nutrient sensing and mitochondrial oxidative capacity in healthy young adults. Physiol Rep 9:e15147.Blood cellsHuman
Glancy 2021 Physiol Rev2021Glancy B, Balaban RS (2021) Energy metabolism design of the striated muscle cell. Physiol Rev 101:1561-607. doi: 10.1152/physrev.00040.2020Skeletal muscle
Riguet 2021 Nat Commun2021Riguet N, Mahul-Mellier AL, Maharjan N, Burtscher J, Croisier M, Knott G, Hastings J, Patin A, Reiterer V, Farhan H, Nasarov S, Lashuel HA (2021) Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties. Nat Commun 12:6579.HEKHuman
Vernerova 2021 Biomedicines2021Vernerova A, Garcia-Souza LF, Soucek O, Kostal M, Rehacek V, Krcmova LK, Gnaiger E, Sobotka O (2021) Mitochondrial respiration of platelets: comparison of isolation methods. https://doi.org/10.3390/biomedicines9121859PlateletHuman
Tallosy 2021 Sci Rep2021Tall贸sy SP, Poles MZ, Rutai A, Fejes R, Juh谩sz L, Buri谩n K, S贸ki J, Szab贸 A, Boros M, Kaszaki J (2021) The microbial composition of the initial insult can predict the prognosis of experimental sepsis. Sci Rep 11:22772.LiverRat
Sharma 2021 Cancer Cell Int2021Sharma P, Sharma V, Ahluwalia TS, Dogra N, Kumar S, Singh S (2021) Let-7a induces metabolic reprogramming in breast cancer cells via targeting mitochondrial encoded ND4. Cancer Cell Int 21:629.Endothelial;epithelial;mesothelial cellHuman
Assis-de-Lemos 2021 Biosci Rep2021Assis-de-Lemos G, Monteiro J, Oliveira-Valen莽a VM, Melo GA, Reis RAM, Rehen SK, Silveira MS, Galina A (2021) Dopamine signaling impairs ROS modulation by mitochondrial hexokinase in human neural progenitor cells. https://doi.org/10.1042/bsr20211191Nervous systemHuman
Fischer 2021 Antioxidants2021Fischer C, Volani C, Koml贸di T, Seifert M, Demetz E, Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, Gnaiger E, Weiss G (2021) Dietary iron overload and Hfe-/- related hemochromatosis alter hepatic mitochondrial function. https://doi.org/10.3390/antiox10111818LiverMouse
Young 2021 J Biol Chem2021Young MP, Schug ZT, Booth DM, Yule DI, Mikoshiba K, Hajn贸czky G, Joseph SK (2021) Metabolic adaptation to the chronic loss of Ca2+ signaling induced by knockout of IP 3 receptors or the mitochondrial Ca2+ uniporter. J Biol Chem 298:101436.HEK
HeLa
Human
Dall 2021 J Biol Chem2021Dall M, Hassing AS, Niu L, Nielsen TS, Ingerslev LR, Sulek K, Trammell SAJ, Gillum MP, Barr猫s R, Larsen S, Poulsen SS, Mann M, 脴rskov C, Treebak JT (2021) Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes. J Biol Chem 297:101388.LiverMouse
Antico 2021 Sci Adv2021Antico O, Ordureau A, Stevens M, Singh F, Nirujogi RS, Gierlinski M, Barini E, Rickwood ML, Prescott A, Toth R, Ganley IG, Harper JW, Muqit MMK (2021) Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1. Sci Adv 7:eabj0722.Nervous systemMouse
Zuccarelli 2021 J Physiol2021Zuccarelli L, Baldassarre G, Magnesa B, Degano C, Comelli M, Gasparini M, Manferdelli G, Marzorati M, Mavelli I, Pilotto A, Porcelli S, Rasica L, 艩imuni膷 B, Pi拧ot R, Narici M, Grassi B (2021) Peripheral impairments of oxidative metabolism after a 10-day bed rest are upstream of mitochondrial respiration. J Physiol 599:4813-29.Skeletal muscleHuman
Liu 2021 Basic Res Cardiol2021Liu N, Kataoka M, Wang Y, Pu L, Dong X, Fu X, Zhang F, Gao F, Liang T, Pei J, Xiao C, Qiu Q, Hong T, Chen Q, Zhao J, Zhu L, He J, Hu X, Nie Y, Zhu W, Yu H, Cowan DB, Hu X, Wang J, Wang DZ, Chen J (2021) LncRNA LncHrt preserves cardiac metabolic homeostasis and heart function by modulating the LKB1-AMPK signaling pathway. Basic Res Cardiol 116:48.HeartMouse
Hester 2021 Pharmaceutics2021Hester S, Ferenz KB, Eitner S, Langer K (2021) Development of a lyophilization process for long-term storage of albumin-based perfluorodecalin-filled artificial oxygen carriers. Pharmaceutics 13:584.Saccharomyces cerevisiae
Souza 2021 PLoS Pathog2021Souza ROO, Damasceno FS, Marsiccobetre S, Biran M, Murata G, Curi R, Bringaud F, Silber AM (2021) Fatty acid oxidation participates in resistance to nutrient-depleted environments in the insect stages of Trypanosoma cruzi. PLoS Pathog 17:1009495.Other cell lines
Bouche 2021 PLoS One2021Bouche L, Kamel R, Tamareille S, Garcia G, Villedieu C, Pillot B, Gueguen N, Chehaitly A, Chao de la Barca JM, Beaumont J, Baetz D, Ovize M, Sesaki H, Henrion D, Reynier P, Lenaers G, Prunier F, Mirebeau-Prunier D (2021) DRP1 haploinsufficiency attenuates cardiac ischemia/reperfusion injuries. PLoS One 16:0248554.HeartMouse
James 2021 Nat Commun2021James OJ, Vandereyken M, Marchingo JM, Singh F, Bray SE, Wilson J, Love AG, Swamy M (2021) IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes. Nat Commun 12:4290.LymphocyteMouse
Liang 2021 Biomed Pharmacother2021Liang L, Zhang G, Cheng C, Li H, Jin T, Su C, Xiao Y, Bradley J, Peberdy MA, Ornato JP, Mangino MJ, Tang W (2021) High-resolution respirometry for evaluation of mitochondrial function on brain and heart homogenates in a rat model of cardiac arrest and cardiopulmonary resuscitation. Biomed Pharmacother 142:111935.Heart
Nervous system
Rat
Drake 2021 Proc Natl Acad Sci U S A2021Drake JC, Wilson RJ, Laker RC, Guan Y, Spaulding HR, Nichenko AS, Shen W, Shang H, Dorn MV, Huang K, Zhang M, Bandara AB, Brisendine MH, Kashatus JA, Sharma PR, Young A, Gautam J, Cao R, Wallrabe H, Chang PA, Wong M, Desjardins EM, Hawley SA, Christ GJ, Kashatus DF, Miller CL, Wolf MJ, Periasamy A, Steinberg GR, Hardie DG, Yan Z (2021) Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy. Proc Natl Acad Sci U S A 118:e2025932118.Skeletal muscleMouse
Cannon 2021 Respir Physiol Neurobiol2021Cannon DT, Nogueira L, Gutierrez-Gonzalez AK, Gilmore NK, Bigby TD, Breen EC (2021) Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416/hypoxia model of pulmonary hypertension. Respir Physiol Neurobiol 295:103783.Skeletal muscleMouse
King 2021 J Biol Chem2021King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, Tandler B, Pergola K, Hermann GE, Rogers RC, L贸pez-Dom猫nech S, Dantas WS, Stadler K, Hoppel CL, Kirwan JP (2021) Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics. J Biol Chem 297:101196.Skeletal muscleMouse
Hoppel 2021 Cells2021Hoppel F, Garcia-Souza LF, Kantner-Rumplmair W, Burtscher M, Gnaiger E, Pesta D, Calabria E (2021) Human platelet mitochondrial function reflects systemic mitochondrial alterations: a protocol for application in field studies. https://doi.org/10.3390/cells10082088PlateletHuman
Watt 2021 Nat Commun2021Watt KI, Henstridge DC, Ziemann M, Sim CB, Montgomery MK, Samocha-Bonet D, Parker BL, Dodd GT, Bond ST, Salmi TM, Lee RS, Thomson RE, Hagg A, Davey JR, Qian H, Koopman R, El-Osta A, Greenfield JR, Watt MJ, Febbraio MA, Drew BG, Cox AG, Porrello ER, Harvey KF, Gregorevic P (2021) Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease. Nat Commun 12:2887.Skeletal muscleMouse
Styles 2021 Cell Death Dis2021Styles FL, Al-Owais MM, Scragg JL, Chuntharpursat-Bon E, Hettiarachchi NT, Lippiat JD, Minard A, Bon RS, Porter K, Sukumar P, Peers C, Roberts LD (2021) Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism. Cell Death Dis 12:372.HEKHuman
Cardinale 2021 J Appl Physiol (1985)2021Cardinale DA, Gejl KD, Petersen KG, Nielsen J, 脴rtenblad N, Larsen FJ (2021) Short-term intensified training temporarily impairs mitochondrial respiratory capacity in elite endurance athletes. J Appl Physiol (1985) 131:388-400.Skeletal muscleHuman
Trinity 2021 J Appl Physiol2021Trinity JD, Craig JC, Fermoyle CC, McKenzie AI, Lewis MT, Park SH, Rondina MT, Richardson RS (2021) Impact of presymptomatic COVID-19 on vascular and skeletal muscle function: a case study. J Appl Physiol (1985) 130:1961-70.Skeletal muscleHuman
Sladowska 2021 PLoS Biol2021Sladowska M, Turek M, Kim MJ, Drabikowski K, Mussulini BHM, Mohanraj K, Serwa RA, Topf U, Chacinska A (2021) Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans. PLoS Biol 19:3001302.Caenorhabditis elegans
Kruse 2021 Life (Basel)2021Kruse CJ, Stern D, Mouithys-Mickalad A, Niesten A, Art T, Lemieux H, Votion DM (2021) In vitro assays for the assessment of impaired mitochondrial bioenergetics in equine atypical myopathy. Life (Basel) 11:719.Skeletal muscleHorse
Dubinin 2021 Membranes (Basel)2021Dubinin MV, Semenova AA, Nedopekina DA, Davletshin EV, Spivak AY, Belosludtsev KN (2021) Effect of F16-betulin conjugate on mitochondrial membranes and its role in cell death initiation. Membranes (Basel) 11:352.LiverRat
Mazzoli 2021 Nutrients2021Mazzoli A, Gatto C, Crescenzo R, Cigliano L, Iossa S (2021) Prolonged changes in hepatic mitochondrial activity and insulin sensitivity by high fructose intake in adolescent rats. Nutrients 13:1370.LiverRat
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