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Hoppel Charles L

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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping


Hoppel Charles L


MitoPedia topics: EAGLE 

COST: Member COST WG1: WG1


Name Hoppel Charles L, Prof., MD

Professor, Pharmacology and Medicine

Chief, Clinical Pharmacology

Director, the Center for Mitochondrial Diseases

Institution
Charles Hoppel
Department of Pharmacology,

Case Western Reserve University School of Medicine, US


Annual Charles L. Hoppel, M.D. Award for Outstanding Contributions in Mitochondrial Research

Address W147 Wood Building, 10900 Euclid Avenue, 44106-4981
City Cleveland
State/Province Ohio (OH)
Country USA
Email [email protected]
Weblink Department of Pharmacology
O2k-Network Lab US OH Cleveland Hoppel CL


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Publications

 PublishedReference
Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research 20222022-11-14Cleveland, OH , 2022 Nov 14. The Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research.
Akinbiyi 2021 Sci Rep2021Akinbiyi EO, Abramowitz LK, Bauer BL, Stoll MSK, Hoppel CL, Hsiao CP, Hanover JA, Mears JA (2021) Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass. Sci Rep 11:22106.
Axelrod 2021 EMBO Mol Med2021Axelrod CL, King WT, Davuluri G, Noland RC, Hall J, Hull M, Dantas WS, Zunica ER, Alexopoulos SJ, Hoehn KL, Langohr I, Stadler K, Doyle H, Schmidt E, Nieuwoudt S, Fitzgerald K, Pergola K, Fujioka H, Mey JT, Fealy C, Mulya A, Beyl R, Hoppel CL, Kirwan JP (2021) BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control. EMBO Mol Med 12:12088.
King 2021 J Biol Chem2021King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, Tandler B, Pergola K, Hermann GE, Rogers RC, López-Domènech S, Dantas WS, Stadler K, Hoppel CL, Kirwan JP (2021) Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics. J Biol Chem 297:101196.
Zunica 2021 Cancer Metab2021Zunica ERM, Axelrod CL, Cho E, Spielmann G, Davuluri G, Alexopoulos SJ, Beretta M, Hoehn KL, Dantas WS, Stadler K, King WT, Pergola K, Irving BA, Langohr IM, Yang S, Hoppel CL, Gilmore LA, Kirwan JP (2021) Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15. Cancer Metab 9:36.
BEC 2020.1 doi10.26124bec2020-0001.v12020Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1
Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research 20192019-11-09Cleveland, OH , 2019 Nov 09. The Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research.
Kumar 2019 Free Radic Biol Med2019Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S (2019) Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy. Free Radic Biol Med 145:284-99.
Lai 2019 Acta Physiol (Oxf)2019Lai N, Kummitha CM, Rosca MG, Fujioka H, Tandler B, Hoppel CL (2019) Isolation of mitochondrial subpopulations from skeletal muscle: Optimizing recovery and preserving integrity. Acta Physiol (Oxf) 225:13182.
Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research 20182018-11-09Cleveland, OH , 2018 Nov 09. The Charles L. Hoppel Prize for Outstanding Contributions in Mitochondrial Research.
Lai 2018 Acta Physiol (Oxf)2018Lai N, M Kummitha C, Rosca MG, Fujioka H, Tandler B, Hoppel CL (2018) Isolation of mitochondrial subpopulations from skeletal muscle: optimizing recovery and preserving integrity. Acta Physiol (Oxf) e13182. doi: 10.1111/apha.13182.
Hsiao 2018 Anal Biochem2018Hsiao CP, Hoppel C (2018) Analyzing mitochondrial function in human peripheral blood mononuclear cells. Anal Biochem 549:12-20.
Chen 2018 Hum Mol Genet2018Chen A, Tiosano D, Guran T, Baris HN, Bayram Y, Mory A, Shapiro-Kulnane L, Hodges CA, Coban Akdemir Z, Turan S, Jhangiani SN, van den Akker F, Hoppel CL, Salz HK, Lupski JR, Buchner DA (2018) Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency. Hum Mol Genet 27:1913-26.
The Hoppel Prize Lectureship in Mitochondrial Biology2017-10-05Cleveland, OH , 2017 Oct 05. The Hoppel Prize Lectureship in Mitochondrial Biology.
Zhou 2017 Biochim Biophys Acta2017Zhou L, Wang W, Hoppel C, Liu J, Zhu X (2017) Parkinson's disease-associated pathogenic VPS35 mutation causes complex I deficits. Biochim Biophys Acta 1863:2791-5.
Davuluri 2016 J Physiol2016Davuluri G, Allawy A, Thapaliya S, Rennison JH, Singh D, Kumar A, Sandlers Y, Van Wagoner DR, Flask CA, Hoppel C, Kasumov T, Dasarathy S (2016) Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress. J Physiol 594:7341-60.
Solinas 2014 Mech Ageing Dev2014Solinas P, Fujioka H, Radivoyevitch T, Tandler B, Hoppel CL (2014) Aging effects on oxidative phosphorylation in rat adrenocortical 3 mitochondria. Mech Ageing Dev 138:10-4.
Ye 2013 Anal Biochem2013Ye F, Hoppel CL (2013) Measuring oxidative phosphorylation in human skin fibroblasts. https://doi.org/10.1016/j.ab.2013.02.010
Rosca 2012 Diabetes2012Rosca MG, Vazquez EJ, Chen Q, Kerner J, Kern TS, Hoppel CL (2012) Oxidation of fatty acids is the source of increased mitochondrial reactive oxygen species production in kidney cortical tubules in early diabetes. Diabetes 61:2074-83. https://doi.org/10.2337/db11-1437
Ye 2011 J Biol Chem2011Ye F, Lemieux H, Hoppel CL, Hanson RW, Hakimi P, Croniger CM, Puchowicz M, Anderson VE, Fujioka H, Stavnezer E (2011) Peroxisome proliferator-activated receptor γ (PPARγ) mediates a Ski-induced shift from glycolysis to oxidative energy metabolism. J Biol Chem 286:40013-24.
Rosca 2011 Biochim Biophys Acta2011Rosca M, Minkler P, Hoppel CL (2011) Cardiac mitochondria in heart failure: Normal cardiolipin profile and increased threonine phosphorylation of Complex IV. Biochim Biophys Acta 1807:1373-82.
Lemieux 2010 J Gerontol A Biol Sci Med Sci2010Lemieux H, Vazquez EJ, Fujioka H, Hoppel CL (2010) Decrease in mitochondrial function in rat cardiac permeabilized fibers correlates with the aging phenotype. J Gerontol A Biol Sci Med Sci 65:1157-64.
Lemieux 2009 JBB2009Lemieux H, Hoppel CL (2009) Mitochondria in the human heart. J. Bioenerg. Biomembr. 41:99-106.
Rosca 2008 Cardiovasc Res2008Rosca MG, Vazquez EJ, Kerner J, Parland W, Chandler MP, Stanley W, Sabbah HN, Hoppel CL (2008) Cardiac mitochondria in heart failure: decrease in respirasomes and oxidative phosphorylation. Cardiovasc Res 80:30-39.
Puchowicz 2004 Mitochondrion2004Puchowicz MA, Varnes ME, Cohen BH, Friedman NR, Kerr DS, Hoppel CL (2004) Oxidative phosphorylation analysis: assessing the integrated functional activity of human skeletal muscle mitochondria-case studies. Mitochondrion 4:377-85.
Kerner 2000 Biochim Biophys Acta2000Kerner J, Hoppel C (2000) Fatty acid import into mitochondria. Biochim Biophys Acta 1486:1-17.
Palmer 1977 J Biol Chem1977Palmer JW, Tandler B, Hoppel CL (1977) Biochemical properties of subsarcolemmal and interfibrillar mitochondria isolated from rat cardiac muscle. J Biol Chem 252:8731-9.
Tomec 1975 Arch Biochem Biophys1975Tomec RJ, Hoppel CL (1975) Carnitine palmitoyltransferase in bovine fetal heart mitochondria. Arch Biochem Biophys 170:716-23.

Abstracts

 PublishedReference
Lai 2022 Abstract Bioblast20225.6. «5 min»
Lai Nicola
Lai Nicola, Kummitha CM, Hoppel CL (2022) Effect of isolation protocol of skeletal muscle mitochondrial subpopulations on bioenergetic function. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »Watch the presentation«
Axelrod 2019 Abstract IOC1412019Axelrod CL, Davuluri G, Zunica ERM, Noland RC, Hoppel CL, Kirwan JP (2019) Administration of BAM15 to obese C57BL/6J mice increases skeletal muscle fatty acid oxidation independent of OXPHOS or ETC capacity. Mitochondr Physiol Network 24.02.
Hoppel 2018 MiPschool Tromso D22018
Charles Hoppel
Mitochondrial function during ischemia/reperfusion injury.
Hoppel 2018 MiPschool Tromso D12018
Charles Hoppel
Two populations of muscle mitochondria: heart and skeletal muscle.
Hoppel 2017 MiPschool Obergurgl E12017
Charles Hoppel
The challenges of functional mitochondrial diagnosis.
Hoppel 2017 MiPschool Obergurgl A2017
Charles Hoppel
Biochemical coupling efficiency and ATP/O2 ratios.
Hoppel 2017 MiP20172017
Charles Hoppel
Pathways of mitochondrial fatty acid oxidation. Hoppel_Presentation
Hoppel 2016b Abstract MitoFit Science Camp 20162016Comparison of permeabilized skeletal muscle fibers or isolated mitochondria for the detection of oxidative phosphorylation defects.
Hoppel 2016c Abstract MitoFit Science Camp 20162016Mitochondrial respiration in permeabilized skin fibroblasts.
Hsiao 2016 Abstract MitoFit Science Camp 20162016Association between mitochondrial bioenergetics and radiation-related fatigue: a possible mechanism and novel target.
Hoppel 2016a Abstract MitoFit Science Camp 20162016Skeletal muscle mitochondria in diagnostic studies.
Lai 2014 Abstract1 MiP20142014Improved isolation of high quality subsarcolemmal and interfibrillar mitochondria from skeletal muscle.
Lai 2014 Abstract2 MiP20142014Bioenergetic differences between permeabilized red and white fibers of a non-obese model of type II diabetes.
Hoppel 2012 Abstract Bioblast2012Hoppel CL (2012) Mitochondrial functional testing – muscle biopsy, isolated mitochondria and others. Mitochondr Physiol Network 17.12.
Rosca MiP20102010Rosca MG, Hoppel CL (2010) Activation of distinct mitochondrial cAMP-PKA compartments induces different effects on mitochondrial function.

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