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| [[File:Bioblast alert.jpg|240px|right]] | | {{Bioblast header page name}} |
| | [[Image:BB-Bioblast.jpg|left|30px|link=Bioblast:About|Bioblast wiki]] |
| | [[File:Bioblast alert.jpg|240px|right|link=Bioblast_alert|Bioblast alert]] |
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| '''Bioblast alert''' is prepared by the [[Bioblast editorial board]] to draw attention to specific topics on the '''Bioblast wiki'''. | | '''[[Bioblast alert|back to "Bioblast alert" main page]]''' |
| '''Bioblast alert''': for information purposes, not intended to be an advertisement.
| | __TOC__ |
| Contributions are welcome.
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| | === Bioblast alert 2015(01): 2015-01-01 === |
| == Bioblast alert 2013 == | |
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| === Bioblast alert 2013(02): 2013-08-08 ===
| | [[Image:BB-Bioblast.jpg|left|30px|link=Gentle Science|Gentle Science]] |
| * '''MitoPedia news''': '''[[CCCP]]''' - Carbonyl cyanide m-chloro phenyl hydrazone: In our on-going experiments with various sources of mitochondria and different mt-preparations, we observed that results on respiration and mt-membrane potential were fully comparable using CCCP or [[FCCP]] as [[uncoupler]]s in parallel experiments. Therefore, from now on our lab will replace FCCP by CCCP. Optimum concentrations for the estimation of [[ETS capacity]] are slightly higher for CCCP compared to FCCP. Importantly, CCCP is far less expensive than FCCP (protocol development supported by ''[[MitoCom_Diagnostic_Concept|MitoCom]]'').
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| * '''Selection of appropriate methodologies''': A recently published review by Perry and colleagues provides a critical assessment of currently used methodologies and instruments used in respirometry – excellent reading. [[Perry_2013_Diabetes|Perry CG, Kane DA, Lanza IR, Neufer PD (2013) Methods for assessing mitochondrial function in diabetes. Diabetes 62: 1041-1053.]]
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| * '''MitoPedia Glossary''' - ''new section'': [[MitoPedia Glossary: Respiratory control ratios|Respiratory control ratios]].
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| | [[Gentle_Science#Bioenergetics_-_Arts_meets_Gentle_Science |'''Bioenergetics - Arts meets Gentle Science''']] - Bioenergetics Exhibition, March 15-June 17, 2015, Science Museum of Virginia, US - a Gentle Science project initiated by [[Iyer S |Shilpa Iyer]]. |
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| === Bioblast alert 2013(01): 2013-07-08 ===
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| * MitoPedia glossary: '''[[Basal respiration]]''' in physiology, cellular bioenergetics and mitochondrial physiology - an updated article, introducing '''[[Bioblast-MitoPedia]]'''.
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| * MitoGlobal project: The '''[[Mitochondrial Global Network]] (MitoGlobal)''' initiates a joint publication to review the state-of-the-art terminology in the rapidly expanding field of mitochondrial respiratory physiology. From the [[MitoPedia Glossary: Respiratory states|present start]] there is a long way to go, and we invite experts in the field to a joint walk, asking for your suggestions - [mailto:[email protected] Email to Erich Gnaiger]. | |
| * '''MiP''summer'' School 2013''': [http://www.mitophysiology.org/?MiPschool2013 Mitochondrial Physiology - "Theory & Praxis"] - the annual highlight that students of cellular bioenergetics and mitochondrial physiology cannot afford to miss! August 26-30, 2013, Copenhagen, Denmark.
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| * '''MiP''conference'' 2013 - Comparative Mitochondrial Physiology''' [http://www.mitophysiology.org/?MiP2013 MiP2013], September 23-27, 2013, Obergurgl, Austria. >>[[MiP2013|MiP2013 abstracts online]]
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| | [[Image:Logo-MiP2014.jpg|left|55px|link=MiP2015|MiPArt by Odra Noel]] |
| | » '''MiP''schools'' 2015''': »» [[MiPschool Cape Town 2015 |'''Cape Town ZA, March 24-28''']] »» [[MiPschool London 2015 |'''London UK, April 20-25''']] »» [[MiPschool Greenville 2015 |'''Greenville US, August 10-14''']]. |
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| == Bioblast alert 2012 ==
| | » [[MiP2015 |'''Mitochondrial Physiology Conference MiP2015, Sep 7-11''']], Luční Bouda, Czech Republic. |
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| === Bioblast alert 2012(08): 2012-12-18 ===
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| * MitoPedia glossary: '''[[Substrate control state]]s''' in mitochondrial preparations versus intact cells - new perspectives in OXPHOS analysis.
| | [[Image:BB-Bioblast.jpg|20px|link=Bioblast:About|Bioblast wiki]] '''[[Bioblast track]]''' - evolving hot Bioblast topics: reflections at the beginning of the New Year. |
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| * MitoPedia topic: The '''[[Mitochondrial Global Network]] (MitoGlobal)''' aims at providing a WorldWide information platform for scientific mitochondrial organizations.
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| :* '''[[MitoGlobal_Events_2013|MitoGlobal Events]]''' are listed by Mitochondrial Global Network, providing a comprehensive list of mitochondrial conferences, workshops, and educational programmes. Send us your event to be included in ''MitoGlobal Events''.
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| :* We invite organizations with a focus on mitochondrial research and medicine to submit your contact details, to be included in the '''[[MitoGlobal Organizations|List of MitoGlobal Organizations]]'''.
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| * '''MiP''conference'' 2013 - Comparative Mitochondrial Physiology''' [http://www.mitophysiology.org/?MiP2013 MiP2013], Obergurgl, 2013 September 23 to 27. >>[[MiP2013|MiP2013 Abstracts]]
| | '''<big><big><big>HRR</big></big></big> - high-resolution respirometry''' was established 20 years ago: [[Gnaiger 1995 J Bioenerg Biomembr |Control of mitochondrial and cellular respiration by oxygen. J Bioenerg Biomembr 1995.]] |
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| === Bioblast alert 2012(07): 2012-10-24 === | | === Bioblast alert 2015(02): 2015-04-28 === |
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| * '''MitoPedia topic''': Publications of historical interest are valued as milestones in science, as sources of understanding currently discussed concepts, and as a reminder that 'nothing' is new (something new is 'nothing'?) >> '''[[Mitochondria and bioblasts: Made history]]''' | | * Gentle Science: The '''Vancouver Protocol''' carries the spirit of Gentle Science. Do involved editors, authors and peer reviewers know that? »[[Gentle_Science#The_Vancouver_Protocol.2C_ICMJE.2C_and_Gentle_Science |''more details'']] |
| * '''MitoPedia terminology''': [[LEAK]] ''vs.'' [[State 2]]: The resting state of substrate supported respiration without ADP (LEAK state) in contrast to the substrate limited State 2 of [[residual oxygen consumption]] at high ADP concentration: >> [[Chance 1955 J Biol Chem-III|Chance and Williams 1955]]. | | * [[MitoGlobal Events]]: '''[[UMDF2015 |Mitochondrial Medicine, UMDF2015]]: Washington DC US, 2015 Jun 17-20'''. |
| : '''MitoPedia Glossary:''' [[Glossary: Respiratory states|'''Respiratory states''']] | | * [[MitoGlobal Organizations]]: Amy Goldstein ([[Mitochondrial_Medicine_Society|Mitochondrial Medicine Society]]) created the '''Mitochondrial Global Networks map'''. »[http://www.mitosoc.org/clinics ''see the map'']. |
| | * Weissig V, Edeas M, eds (2015) Mitochondrial medicine: probing mitochondrial function. [[Weissig_2015_Methods_Mol_Biol_I |Methods Mol Biol 1264:1-480]]. |
| | * MitoPedia: '''What is wrong with the RCR?''' »''Find out:'' [[Image:j--P.jpg|50 px|link=OXPHOS-coupling efficiency |OXPHOS-coupling efficiency]] [[OXPHOS-coupling efficiency]] |
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| * [[Bioblast 2012|'''Bioblast 2012''': Conference on Mitochondrial Competence]] in the spirit of [[Gentle Science]].
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| * [[Petition to protect EU science budget]]
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| | === Bioblast alert 2015(03): 2015-07-03 === |
| === [[Bioblast alert|Bioblast alert]] 2012(06): 2012-07-20 === | |
| * '''MitoPedia news''': [[Myxothiazol]] is available again, ''but what about'' [[glycerophosphate|α-glycerophosphate]] ?
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| :: >> More information on the '''MitoPedia list''' [[List of substrates and metabolites|'''Substrates and metabolites''']]
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| * '''MitoPedia terminology''': [[State 3]] - is [ADP] saturating? ''Not generally in State 3, but certainly in the'' [[OXPHOS capacity|OXPHOS state]] (''P'').
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| :: >> Update on the '''MitoPedia glossary:''' [[Glossary: Respiratory states|'''Respiratory states''']]
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| * '''Hypoxia and high altitude''': [[CH Zurich Lundby C]], [[DK Copenhagen Boushel RC]], [[AT Innsbruck Gnaiger E]]
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| :* [[Jacobs 2012 Exp Physiol|Jacobs RA, Boushel RC, Wright-Paradis C, Calbet JA, Robach P, Gnaiger E, Lundby C (2012) Mitochondrial function in human skeletal muscle following high altitude exposure. Exp Physiol [Epub ahead of print].]]
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| :* [[Robach 2012 Br J Sports Med|Robach P, Siebenmann C, Jacobs RA, Rasmussen P, Nordsborg N, Pesta D, Gnaiger E, Díaz V, Christ A, Fiedler J, Crivelli N, Secher NH, Pichon A, Maggiorini M, Lundby C (2012) The role of haemoglobin mass on VO<sub>2max</sub> following normobaric 'live high-train low' in endurance-trained athletes. Br J Sports Med Jul 12. [Epub ahead of print].]]
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| :* [[Pesta 2011 Am J Physiol Regul Integr Comp Physiol|Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans. Am J Physiol Regul Integr Comp Physiol 301: R1078–R1087.]]
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| :* [[Scandurra 2010 Adv Exp Med Biol|Scandurra FM, Gnaiger E (2010) Cell respiration under hypoxia: Facts and artefacts in mitochondrial oxygen kinetics. Adv Exp Med Biol 662: 7-25.]]
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| | [[Image:MitoPedia.jpg|40px|link=MitoPedia|MitoPedia]] » '''[[Melatonin |Melatonin beyond the clock]]''' |
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| === Bioblast alert 2012(05): 2012-06-05 ===
| | [[Image:MitoPedia.jpg|40px|link=MitoPedia|MitoPedia]] [[Image:R.jpg|link=ROUTINE respiration|ROUTINE]] - [[Image:L.jpg|link=LEAK respiration|LEAK]] - [[Image:E.jpg|link=ET capacity|ETS]] - [[Image:ROX.jpg|link=Residual oxygen consumption|ROX]]: this is the 'phosphorylation control protocol' (PCP) for intact cells - or better '''[[coupling-control protocol]]''' (CCP)? |
| * '''MitoPedia topic''': '''''Mitochondria and Genetics''''' - '''''[[Peroxisome proliferator-activated receptor gamma coactivator 1-alpha|the Coactivator PGC-1α]]'''''
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| * '''Bioblast announcement''': [http://www.umdf.org/site/c.piKYL1PHLtF/b.4864979/k.C003/Home.htm UMDF: Mitochondrial Medicine 2012] - 2012-June-13 to 16 - Capitol Hill, Bethesda, Washington DC, USA
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| * '''Comparison of common bioenergetic analysis methods''': [[Zhang_2012_Nat Protoc|Zhang J, Nuebel E, Wisidagama DR, Setoguchi K, Hong JS, Van Horn CM, Imam SS, Vergnes L, Malone CS, Koehler CM, Teitell MA (2012) Measuring energy metabolism in cultured cells, including human pluripotent stem cells and differentiated cells Nat Protoc 7: 1068-1085.]] >> ''Continue the [[O2k_versus_multiwell_respirometer|discussion]]''
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| | » Special Issue on [[Media:Mitochondrial_Biology_Toxicology_and_Medicine.pdf | Mitochondrial Biology, Toxicology, and Medicine]] by Ryan J. Mailloux, University of Ottawa,Ottawa, Canada ([mailto:[email protected] [email protected]]) - deadline August 14, 2015. |
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| === Bioblast alert 2012(04): 2012-04-29 ===
| | » [[MitoGlobal Events]]: [[MiP2015]] - early registration deadline July 14! |
| * '''MitoPedia topic''': '''''Mitochondria''''' - can we decide on a common abbreviation? - or simply call them '''''[[Bioblasts]]'''''. --> '''[[Mitochondria]]''' and [[Talk:Mitochondria]]
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| * '''Bioblast news''': '''Light in the powerhouse of the cells''' - [http://www.oroboros.at/?Houska-Award_2011 a mt-project is the winner of the Houska Award 2011].
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| * '''Comparative mt-physiology - life style and training:'''
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| ::[[Votion 2012 PLoS One|Votion DM, Gnaiger E, Lemieux H, Mouithys-Mickalad A, Serteyn D (2012) Physical fitness and mitochondrial respiratory capacity in horse skeletal muscle. PLoS One 7(4): e34890.]]
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| === Bioblast alert 2012(03): 2012-03-23 / 2012-04-03 === | | === Bioblast alert 2015(04): 2015-08-24 === |
| '''MitoPedia topic''': '''[[Permeabilized_muscle_fibres#Oxygen_dependence_of_ROS_production_-_are_permeabilized_fibres_a_valid_model.3F|Oxygen dependence of ROS production - are permeabilized fibres a valid model?]]'''
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| --> [[Talk:Permeabilized muscle fibres|'''''Discussion''''']] | | [[Image:Logo-MiP2014.jpg|40px|link=MiP2015|MiPArt by Odra Noel]] [[MitoGlobal Events]]: Programme '''Mitochondrial Physiology Conference, CZ, Sept 2015''' now online: '''»[[MiP2015]]«'''. Last-minute registrations are encouraged - a special opportunity for MiP''members'', students and young investigators - no surcharge for late registration. |
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| '''''Drosophila'' vs. sandworm: High-resolution respirometry in permeabilized muscle fibres'''
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| # [[Pichaud 2012 Comp Biochem Physiol A Mol Integr Physiol|Pichaud N, Rioux P, Blier PU (2012) In situ quantification of mitochondrial respiration in permeabilized fibers of a marine invertebrate with low aerobic capacity. Comp Biochem Physiol A Mol Integr Physiol 161: 429-435.]]
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| # [[Pichaud 2011 Am J Physiol Regul Integr Comp Physiol|Pichaud N, Ballard JW, Tanguay RM, Blier PU (2011) Thermal sensitivity of mitochondrial functions in permeabilized muscle fibers from two populations of Drosophila simulans with divergent mitotypes. Am J Physiol Regul Integr Comp Physiol 301: R48-R49.]]
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| ''New from the Ballard lab'':
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| * [[Horan 2012 J Gerontol A Biol Sci Med Sci|Horan MP, Pichaud N, Ballard JW (2012) Review: Quantifying mitochondrial dysfunction in complex diseases of aging. J Gerontol A Biol Sci Med Sci [Epub ahead of print].]]
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| === Bioblast alert 2012(02): 2012-03-06 ===
| | [[Image:BB-Bioblast.jpg|30px|link=Bioblast:About|Bioblast wiki]] Send your favourite '''» [[Bioblast picture of the month]]'''. |
| * '''50 Years ago''': '''Nick Holonyak''', considered as the "father of the light-emitting diode", developed the first practical '''visible-spectrum LED in 1962'''. ''Which colour? What is a'' '''LED'''''?'' >>> see '''[[Light emitting diode|Glossary: Fluorescence]]'''
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| '''Mitochondrial dys/function in obesity vs. anorexia''': | | [[Image:MitoGlobal.jpg|40px|link=Mitochondrial_Global_Network|MitoGlobal]] 5 years ago: the '''Bioblast Boost''' » [[Bioblast:About]] |
| # [[Lindfors 2011 Proc Natl Acad Sci U S A|Lindfors C, Nilsson IA, Garcia-Roves PM, Zuberi AR, Karimi M, Donahue LR, Roopenian DC, Mulder J, Uhlén M, Ekström TJ, Davisson MT, Hökfelt TG, Schalling M, Johansen JE (2011) Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse. Proc Natl Acad Sci U S A 108: 18108-18113.]]
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| # [[Holmstroem 2012 Am J Physiol Endocrinol Metab|Holmstroem MH, Iglesias-Gutierrez E, Zierath JR, Garcia-Roves PM (2012) Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes. Am J Physiol Endocrinol Metab 302: E731-E739.]]
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| | [[Image:MitoPedia.jpg|40px|link=MitoPedia|MitoPedia]] » [[MitoPedia: Respiratory states]]: apparent excess capacities of respiration [[Image:ExP.jpg|60 px|link=Excess E-P capacity|Excess ''E-P'' capacity]] [[Image:ExR.jpg|60 px|link=Excess E-R capacity|Excess ''E-R'' capacity]] |
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| === Bioblast alert 2012(01): 2012-02-27 ===
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| Two exciting publications on '''mitochondrial [[p50|''p''<sub>50</sub>]]''', apparent [[excess capacity]] of cytochrome c oxidase, '''[[basal metabolic rate]]''', [[P/O ratio]]s and ergometric [[efficiency]]:
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| # [[Larsen_2011_FASEB_J|Larsen FJ, Schiffer TA, Sahlin K, Ekblom B, Weitzberg E, Lundberg JO (2011) Mitochondrial oxygen affinity predicts basal metabolic rate in humans. FASEB J 25: 2843-2852.]]
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| # [[Larsen_2011_Cell_Metab|Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, Weitzberg E (2011) Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab 13: 149-159.]]
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| == Bioblast alert - feedback ==
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| * ''Eine tolle und sehr nützliche Website!'' (This is a great and useful webpage!) - [[Schatz G|Gottfried Schatz]], Basel, CH (2012-10-28)
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| * ''I have been absolutely astonished by the quantity and quality of online information made available by Oroboros through Bioblast and the associated resources.'' [[Fessel JP|Josh Fessel]] Nashville, TN, US (2012-11-26)
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| == Bioblast alert - previous issues == | | == Bioblast alert - previous issues == |
| | | * [[Bioblast alert 2015]] |
| | * [[Bioblast alert 2014]] |
| | * [[Bioblast alert 2013]] |
| | * [[Bioblast alert 2012]] |
| * [[Bioblast alert 2011]] | | * [[Bioblast alert 2011]] |
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| [[Category:Gentle Science]] | | [[Category:Gentle Science]] |
Bioblast alert 2015
Bioblast track - evolving hot Bioblast topics: reflections at the beginning of the New Year.
OXPHOS-coupling efficiency
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: this is the 'phosphorylation control protocol' (PCP) for intact cells - or better coupling-control protocol (CCP)?
MitoGlobal Events: Programme Mitochondrial Physiology Conference, CZ, Sept 2015 now online: »MiP2015«. Last-minute registrations are encouraged - a special opportunity for MiPmembers, students and young investigators - no surcharge for late registration.
5 years ago: the Bioblast Boost » Bioblast:About
